Activated (HLA-DR +) T-Lymphocyte Subsets in Early Epithelial Ovarian Cancer and Malignant Ovarian Germ Cell Tumors
We examined peripheral blood T-lymphocyte subsets before initiation of therapy in 79 healthy controls, 3 patients with endometriosis, 95 patients with common epithelial tumors of the ovary, 15 patients with ovarian germ cell tumors, and 3 patients with ovarian sex cord-stromal tumors. In stage Ia/Ib...
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| Veröffentlicht in: | Gynecologic oncology 1995-09, Vol.58 (3), p.362-367 |
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| container_title | Gynecologic oncology |
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| creator | Miyazaki, K. Shimada, K. Katabuchi, H. Arakane, F. Arao, S. Okamura, H. |
| description | We examined peripheral blood T-lymphocyte subsets before initiation of therapy in 79 healthy controls, 3 patients with endometriosis, 95 patients with common epithelial tumors of the ovary, 15 patients with ovarian germ cell tumors, and 3 patients with ovarian sex cord-stromal tumors. In stage Ia/Ib patients with epithelial ovarian cancer, the percentages of activated CD4
+ (CD4
+HLA-DR
+) T cells and activated CD4+ T cells in the CD4
+ T-cell subsets were significantly higher than those of healthy controls and patients with benign or borderline epithelial tumors of the ovary. These immonologic parameters were subsequently decreased in patients in stage Ic and more advanced stages. In malignant ovarian germ cell tumors, a similar increase in the CD4
+ T-cell subsets was observed. Moreover, the percentage of activated CD8
+ T cells in the CD8
+ T-cell subsets in stage Ia/Ib patients increased significantly compared with those in healthy controls and patients with benign tumors. Our findings indicate that activated T lymphocytes may play some roles in oncogenesis and progression of both epithelial ovarian cancer and malignant ovarian germ cell tumors. |
| doi_str_mv | 10.1006/gyno.1995.1243 |
| format | Article |
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+ (CD4
+HLA-DR
+) T cells and activated CD4+ T cells in the CD4
+ T-cell subsets were significantly higher than those of healthy controls and patients with benign or borderline epithelial tumors of the ovary. These immonologic parameters were subsequently decreased in patients in stage Ic and more advanced stages. In malignant ovarian germ cell tumors, a similar increase in the CD4
+ T-cell subsets was observed. Moreover, the percentage of activated CD8
+ T cells in the CD8
+ T-cell subsets in stage Ia/Ib patients increased significantly compared with those in healthy controls and patients with benign tumors. Our findings indicate that activated T lymphocytes may play some roles in oncogenesis and progression of both epithelial ovarian cancer and malignant ovarian germ cell tumors.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.1995.1243</identifier><identifier>PMID: 7672702</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>AIDS/HIV ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - pathology ; CD8-Positive T-Lymphocytes - pathology ; Female ; Female genital diseases ; Germinoma - pathology ; Gynecology. Andrology. Obstetrics ; HLA-DR Antigens - analysis ; Humans ; Lymphocyte Activation ; Medical sciences ; Neoplasm Staging ; Ovarian Neoplasms - pathology ; Sex Cord-Gonadal Stromal Tumors - pathology ; T-Lymphocyte Subsets - pathology ; Tumors</subject><ispartof>Gynecologic oncology, 1995-09, Vol.58 (3), p.362-367</ispartof><rights>1995 Academic Press</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-414e3d5e1495e41650494114c5374c7762b877aed0d45ab3d16a2abb513c51233</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090825885712437$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3650432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7672702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyazaki, K.</creatorcontrib><creatorcontrib>Shimada, K.</creatorcontrib><creatorcontrib>Katabuchi, H.</creatorcontrib><creatorcontrib>Arakane, F.</creatorcontrib><creatorcontrib>Arao, S.</creatorcontrib><creatorcontrib>Okamura, H.</creatorcontrib><title>Activated (HLA-DR +) T-Lymphocyte Subsets in Early Epithelial Ovarian Cancer and Malignant Ovarian Germ Cell Tumors</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>We examined peripheral blood T-lymphocyte subsets before initiation of therapy in 79 healthy controls, 3 patients with endometriosis, 95 patients with common epithelial tumors of the ovary, 15 patients with ovarian germ cell tumors, and 3 patients with ovarian sex cord-stromal tumors. In stage Ia/Ib patients with epithelial ovarian cancer, the percentages of activated CD4
+ (CD4
+HLA-DR
+) T cells and activated CD4+ T cells in the CD4
+ T-cell subsets were significantly higher than those of healthy controls and patients with benign or borderline epithelial tumors of the ovary. These immonologic parameters were subsequently decreased in patients in stage Ic and more advanced stages. In malignant ovarian germ cell tumors, a similar increase in the CD4
+ T-cell subsets was observed. Moreover, the percentage of activated CD8
+ T cells in the CD8
+ T-cell subsets in stage Ia/Ib patients increased significantly compared with those in healthy controls and patients with benign tumors. Our findings indicate that activated T lymphocytes may play some roles in oncogenesis and progression of both epithelial ovarian cancer and malignant ovarian germ cell tumors.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Germinoma - pathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HLA-DR Antigens - analysis</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Sex Cord-Gonadal Stromal Tumors - pathology</subject><subject>T-Lymphocyte Subsets - pathology</subject><subject>Tumors</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1rGzEQhkVpSd20194KOpSSUtaRVtJq92gcNym4BFrnLGalcaKyH66kNey_7y42vvU0h_eZl5mHkI-cLTljxe3z2PVLXlVqyXMpXpEFZ5XKilJVr8mCsYplZa7Kt-RdjH8YY4Lx_Ipc6ULnmuULElc2-SMkdPTmYbvK7n7Rb1_pLtuO7eGlt2NC-nuoI6ZIfUc3EJqRbg4-vWDjoaGPRwgeOrqGzmKg0Dn6Exr_3EGXLuE9hpausWnobmj7EN-TN3toIn44z2vy9H2zWz9k28f7H-vVNrOiKFMmuUThFHJZKZS8UExWknNpldDSal3kdak1oGNOKqiF4wXkUNeKC6t4LsQ1-XLqPYT-74AxmdZHO90BHfZDNForzkSlJnB5Am3oYwy4N4fgWwij4czMls1s2cyWzWx5Wvh0bh7qFt0FP2ud8s_nHKKFZh8mPT5eMDH_ImasPGE4WTh6DCZaj5NJ5wPaZFzv_3fBP_AmlnM</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Miyazaki, K.</creator><creator>Shimada, K.</creator><creator>Katabuchi, H.</creator><creator>Arakane, F.</creator><creator>Arao, S.</creator><creator>Okamura, H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>Activated (HLA-DR +) T-Lymphocyte Subsets in Early Epithelial Ovarian Cancer and Malignant Ovarian Germ Cell Tumors</title><author>Miyazaki, K. ; Shimada, K. ; Katabuchi, H. ; Arakane, F. ; Arao, S. ; Okamura, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-414e3d5e1495e41650494114c5374c7762b877aed0d45ab3d16a2abb513c51233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Germinoma - pathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HLA-DR Antigens - analysis</topic><topic>Humans</topic><topic>Lymphocyte Activation</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Sex Cord-Gonadal Stromal Tumors - pathology</topic><topic>T-Lymphocyte Subsets - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyazaki, K.</creatorcontrib><creatorcontrib>Shimada, K.</creatorcontrib><creatorcontrib>Katabuchi, H.</creatorcontrib><creatorcontrib>Arakane, F.</creatorcontrib><creatorcontrib>Arao, S.</creatorcontrib><creatorcontrib>Okamura, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyazaki, K.</au><au>Shimada, K.</au><au>Katabuchi, H.</au><au>Arakane, F.</au><au>Arao, S.</au><au>Okamura, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activated (HLA-DR +) T-Lymphocyte Subsets in Early Epithelial Ovarian Cancer and Malignant Ovarian Germ Cell Tumors</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>58</volume><issue>3</issue><spage>362</spage><epage>367</epage><pages>362-367</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>We examined peripheral blood T-lymphocyte subsets before initiation of therapy in 79 healthy controls, 3 patients with endometriosis, 95 patients with common epithelial tumors of the ovary, 15 patients with ovarian germ cell tumors, and 3 patients with ovarian sex cord-stromal tumors. In stage Ia/Ib patients with epithelial ovarian cancer, the percentages of activated CD4
+ (CD4
+HLA-DR
+) T cells and activated CD4+ T cells in the CD4
+ T-cell subsets were significantly higher than those of healthy controls and patients with benign or borderline epithelial tumors of the ovary. These immonologic parameters were subsequently decreased in patients in stage Ic and more advanced stages. In malignant ovarian germ cell tumors, a similar increase in the CD4
+ T-cell subsets was observed. Moreover, the percentage of activated CD8
+ T cells in the CD8
+ T-cell subsets in stage Ia/Ib patients increased significantly compared with those in healthy controls and patients with benign tumors. Our findings indicate that activated T lymphocytes may play some roles in oncogenesis and progression of both epithelial ovarian cancer and malignant ovarian germ cell tumors.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>7672702</pmid><doi>10.1006/gyno.1995.1243</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic oncology, 1995-09, Vol.58 (3), p.362-367 |
| issn | 0090-8258 1095-6859 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | AIDS/HIV Biological and medical sciences CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - pathology Female Female genital diseases Germinoma - pathology Gynecology. Andrology. Obstetrics HLA-DR Antigens - analysis Humans Lymphocyte Activation Medical sciences Neoplasm Staging Ovarian Neoplasms - pathology Sex Cord-Gonadal Stromal Tumors - pathology T-Lymphocyte Subsets - pathology Tumors |
| title | Activated (HLA-DR +) T-Lymphocyte Subsets in Early Epithelial Ovarian Cancer and Malignant Ovarian Germ Cell Tumors |
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