Presynaptic calcium channels: Pharmacology and regulation
Voltage-dependent Ca 2+ channels are considered as molecular trigger elements for signal transmission at chemical synapses. Due to their central role in this fundamental process, function and pharmacology of presynaptic Ca 2+ channels have recently been the subject of extensive exploration employing...
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| Veröffentlicht in: | Neurochemistry international 1995-06, Vol.26 (6), p.539-558 |
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| container_title | Neurochemistry international |
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| creator | Tareilus, Erwin Breer, Heinz |
| description | Voltage-dependent Ca
2+ channels are considered as molecular trigger elements for signal transmission at chemical synapses. Due to their central role in this fundamental process, function and pharmacology of presynaptic Ca
2+ channels have recently been the subject of extensive exploration employing various experimental techniques. Several lines of evidence indicate that, at nerve terminals in higher vertebrates, the evoked influx of Ca
2+-ions is mainly mediated by Ca
2+ channels of the P-type. The stringent regulation of presynaptic Ca
2+ channels is supposed to be involved in fine-tuning the efficiency of synaptic transmission. Intrinsic control mechanisms, such as voltage- or Ca
2+-dependent inactivation, or modulation of channel activity, either by G-proteins directly or via phosphorylation by protein kinases, may be of particular functional importance. |
| doi_str_mv | 10.1016/0197-0186(94)00149-O |
| format | Article |
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2+ channels are considered as molecular trigger elements for signal transmission at chemical synapses. Due to their central role in this fundamental process, function and pharmacology of presynaptic Ca
2+ channels have recently been the subject of extensive exploration employing various experimental techniques. Several lines of evidence indicate that, at nerve terminals in higher vertebrates, the evoked influx of Ca
2+-ions is mainly mediated by Ca
2+ channels of the P-type. The stringent regulation of presynaptic Ca
2+ channels is supposed to be involved in fine-tuning the efficiency of synaptic transmission. Intrinsic control mechanisms, such as voltage- or Ca
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2+ channels are considered as molecular trigger elements for signal transmission at chemical synapses. Due to their central role in this fundamental process, function and pharmacology of presynaptic Ca
2+ channels have recently been the subject of extensive exploration employing various experimental techniques. Several lines of evidence indicate that, at nerve terminals in higher vertebrates, the evoked influx of Ca
2+-ions is mainly mediated by Ca
2+ channels of the P-type. The stringent regulation of presynaptic Ca
2+ channels is supposed to be involved in fine-tuning the efficiency of synaptic transmission. Intrinsic control mechanisms, such as voltage- or Ca
2+-dependent inactivation, or modulation of channel activity, either by G-proteins directly or via phosphorylation by protein kinases, may be of particular functional importance.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium Channels - metabolism</subject><subject>Calcium Channels - physiology</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. Methods</subject><subject>Humans</subject><subject>Receptors, Presynaptic - drug effects</subject><subject>Receptors, Presynaptic - metabolism</subject><subject>Synapses - drug effects</subject><subject>Synapses - metabolism</subject><subject>Synapses - physiology</subject><subject>Vertebrata</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVJSZ20_6CFPYSSHDYZefWxyiFQTJIWDPahPQt5dpSo7Icj7Qb877tbGx-T0zDMM-8MD2NfOVxz4OoGuNE58FJdGnEFwIXJVx_YjJd6nhstxQmbHZFP7CylvwCgDchTdqqVhkKWM2bWkdKudds-YIauxjA0GT67tqU63WbrZxcbh13dPe0y11ZZpKehdn3o2s_so3d1oi-Hes7-PNz_XvzMl6vHX4sfyxyFUH0uSZkSkYSX0oyNVLokIzeF43LuFNfCG_AESH6j537OCRwVxlcFooCNKs7Z933uNnYvA6XeNiEh1bVrqRuS1VpCqU35LshVqUQhp0SxBzF2KUXydhtD4-LOcrCTWjt5s5M3a4T9r9auxrVvh_xh01B1XDq4HOcXh7lLo0kfXYshHbFC6gLUdP1uj42C6TVQtAkDtUhViIS9rbrw9h__ACQGlK0</recordid><startdate>19950601</startdate><enddate>19950601</enddate><creator>Tareilus, Erwin</creator><creator>Breer, Heinz</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950601</creationdate><title>Presynaptic calcium channels: Pharmacology and regulation</title><author>Tareilus, Erwin ; Breer, Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-5e698cce4f5595e65678e95b3a152a6174f90fe0cefb72f21e0ae39fd3cc40b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium Channels - metabolism</topic><topic>Calcium Channels - physiology</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Models. Methods</topic><topic>Humans</topic><topic>Receptors, Presynaptic - drug effects</topic><topic>Receptors, Presynaptic - metabolism</topic><topic>Synapses - drug effects</topic><topic>Synapses - metabolism</topic><topic>Synapses - physiology</topic><topic>Vertebrata</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tareilus, Erwin</creatorcontrib><creatorcontrib>Breer, Heinz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tareilus, Erwin</au><au>Breer, Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presynaptic calcium channels: Pharmacology and regulation</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>26</volume><issue>6</issue><spage>539</spage><epage>558</epage><pages>539-558</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><coden>NEUIDS</coden><abstract>Voltage-dependent Ca
2+ channels are considered as molecular trigger elements for signal transmission at chemical synapses. Due to their central role in this fundamental process, function and pharmacology of presynaptic Ca
2+ channels have recently been the subject of extensive exploration employing various experimental techniques. Several lines of evidence indicate that, at nerve terminals in higher vertebrates, the evoked influx of Ca
2+-ions is mainly mediated by Ca
2+ channels of the P-type. The stringent regulation of presynaptic Ca
2+ channels is supposed to be involved in fine-tuning the efficiency of synaptic transmission. Intrinsic control mechanisms, such as voltage- or Ca
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| ispartof | Neurochemistry international, 1995-06, Vol.26 (6), p.539-558 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Calcium Channels - metabolism Calcium Channels - physiology Electrophysiology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Receptors, Presynaptic - drug effects Receptors, Presynaptic - metabolism Synapses - drug effects Synapses - metabolism Synapses - physiology Vertebrata Vertebrates: nervous system and sense organs |
| title | Presynaptic calcium channels: Pharmacology and regulation |
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