Attenuation by pimozide of the suppressant effect of d-amphetamine on operant behaviour
The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-int...
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| Veröffentlicht in: | Psychopharmacologia 1987-01, Vol.91 (2), p.239-243 |
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| creator | MORLEY, M. J BRADSHAW, C. M SZABADI, E |
| description | The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozide (0.0625, 0.125, 0.25, 0.5 mg/kg) suppressed performance maintained under both schedules in a dose-dependent manner, the degrees of suppression being equivalent in the two schedules. In Experiment 2, 12 rats responded under the same schedules. d-Amphetamine (0.1-3.2 mg/kg) suppressed performance under both schedules, the degree of suppression being somewhat greater in the case of variable-interval 30-s. Pre-treatment with pimozide (0.0625, 0.125 mg/kg) significantly attenuated the suppressant effect of d-amphetamine under both schedules. It is suggested that D2-dopamine receptors may be involved in mediating the suppressant effect of d-amphetamine on operant behaviour. |
| doi_str_mv | 10.1007/BF00217071 |
| format | Article |
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It is suggested that D2-dopamine receptors may be involved in mediating the suppressant effect of d-amphetamine on operant behaviour.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/BF00217071</identifier><identifier>PMID: 3107040</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Catecholaminergic system ; Conditioning, Operant - drug effects ; Dextroamphetamine - antagonists & inhibitors ; Dextroamphetamine - pharmacology ; Dose-Response Relationship, Drug ; Female ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. 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M</creatorcontrib><creatorcontrib>SZABADI, E</creatorcontrib><title>Attenuation by pimozide of the suppressant effect of d-amphetamine on operant behaviour</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozide (0.0625, 0.125, 0.25, 0.5 mg/kg) suppressed performance maintained under both schedules in a dose-dependent manner, the degrees of suppression being equivalent in the two schedules. In Experiment 2, 12 rats responded under the same schedules. d-Amphetamine (0.1-3.2 mg/kg) suppressed performance under both schedules, the degree of suppression being somewhat greater in the case of variable-interval 30-s. Pre-treatment with pimozide (0.0625, 0.125 mg/kg) significantly attenuated the suppressant effect of d-amphetamine under both schedules. It is suggested that D2-dopamine receptors may be involved in mediating the suppressant effect of d-amphetamine on operant behaviour.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Conditioning, Operant - drug effects</subject><subject>Dextroamphetamine - antagonists & inhibitors</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Pimozide - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reinforcement Schedule</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRaq1u3AtZiAsheueRTLKsxapQcKO4DDOTOzSSlzMTof56U1rq0rs5XM7HWXyEXFK4owDy_mEJwKgESY_IlArOYgaSHZMpAOcxp0l2Ss68_4TxRCYmZMIpSBAwJR_zELAdVKi6NtKbqK-a7qcqMepsFNYY-aHvHXqv2hChtWjCtilj1fRrDKqp2hFto65Ht0U0rtV31Q3unJxYVXu82OeMvC8f3xbP8er16WUxX8WGCxbiJM0Yl1TmacryHK0QVtBMJAak1iqTKgdpRVmqkmepLtFozRKBwEwJyfjzGbnZ7fau-xrQh6KpvMG6Vi12gy-kTEDmjP8LUpGmlGV0BG93oHGd9w5t0buqUW5TUCi2uos_3SN8tV8ddIPlAd37Hfvrfa-8UbUdJZnKHzApMgqjgV-akIan</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>MORLEY, M. J</creator><creator>BRADSHAW, C. 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M ; SZABADI, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-56823717966299ef44f41845c07bba87a907f4ddad386bdecbb254e02cd05bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Conditioning, Operant - drug effects</topic><topic>Dextroamphetamine - antagonists & inhibitors</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Pimozide - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reinforcement Schedule</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORLEY, M. J</creatorcontrib><creatorcontrib>BRADSHAW, C. M</creatorcontrib><creatorcontrib>SZABADI, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORLEY, M. J</au><au>BRADSHAW, C. M</au><au>SZABADI, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation by pimozide of the suppressant effect of d-amphetamine on operant behaviour</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>91</volume><issue>2</issue><spage>239</spage><epage>243</epage><pages>239-243</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozide (0.0625, 0.125, 0.25, 0.5 mg/kg) suppressed performance maintained under both schedules in a dose-dependent manner, the degrees of suppression being equivalent in the two schedules. In Experiment 2, 12 rats responded under the same schedules. d-Amphetamine (0.1-3.2 mg/kg) suppressed performance under both schedules, the degree of suppression being somewhat greater in the case of variable-interval 30-s. Pre-treatment with pimozide (0.0625, 0.125 mg/kg) significantly attenuated the suppressant effect of d-amphetamine under both schedules. It is suggested that D2-dopamine receptors may be involved in mediating the suppressant effect of d-amphetamine on operant behaviour.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3107040</pmid><doi>10.1007/BF00217071</doi><tpages>5</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 1987-01, Vol.91 (2), p.239-243 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Catecholaminergic system Conditioning, Operant - drug effects Dextroamphetamine - antagonists & inhibitors Dextroamphetamine - pharmacology Dose-Response Relationship, Drug Female Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pimozide - pharmacology Rats Rats, Inbred Strains Reinforcement Schedule |
| title | Attenuation by pimozide of the suppressant effect of d-amphetamine on operant behaviour |
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