Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice
We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent ev...
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| Veröffentlicht in: | Nature genetics 1995-08, Vol.10 (4), p.466-471 |
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| container_issue | 4 |
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| container_title | Nature genetics |
| container_volume | 10 |
| creator | Rugarli, Elena I. Adler, David A. Borsani, Giuseppe Tsuchiya, Karen Franco, Brunella Hauge, Xueya Disteche, Christine Chapman, Verne Ballabio, Andrea |
| description | We report the unprecedented finding of a gene with a different map position in two mouse strains. The
Clcn4
gene was found to map to the X chromosome in the wild Mediterrean mouse,
Mus spretus
but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis. |
| doi_str_mv | 10.1038/ng0895-466 |
| format | Article |
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Clcn4
gene was found to map to the X chromosome in the wild Mediterrean mouse,
Mus spretus
but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng0895-466</identifier><identifier>PMID: 7670496</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Amino Acid Sequence ; Animal Genetics and Genomics ; Animals ; Base Sequence ; Biological and medical sciences ; Biological Evolution ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chloride Channels - genetics ; Chromosome Mapping ; Classical genetics, quantitative genetics, hybrids ; DNA Primers ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Gene Rearrangement ; Genetics of eukaryotes. Biological and molecular evolution ; Human Genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Muridae ; Sequence Homology, Amino Acid ; Species Specificity ; Vertebrata ; X Chromosome</subject><ispartof>Nature genetics, 1995-08, Vol.10 (4), p.466-471</ispartof><rights>Springer Nature America, Inc. 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-c5e3e6d8c08610ffd9eec2c20a262006882bf378ee1825ef18f423e3d35ea1e53</citedby><cites>FETCH-LOGICAL-c378t-c5e3e6d8c08610ffd9eec2c20a262006882bf378ee1825ef18f423e3d35ea1e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng0895-466$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng0895-466$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3618992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7670496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rugarli, Elena I.</creatorcontrib><creatorcontrib>Adler, David A.</creatorcontrib><creatorcontrib>Borsani, Giuseppe</creatorcontrib><creatorcontrib>Tsuchiya, Karen</creatorcontrib><creatorcontrib>Franco, Brunella</creatorcontrib><creatorcontrib>Hauge, Xueya</creatorcontrib><creatorcontrib>Disteche, Christine</creatorcontrib><creatorcontrib>Chapman, Verne</creatorcontrib><creatorcontrib>Ballabio, Andrea</creatorcontrib><title>Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>We report the unprecedented finding of a gene with a different map position in two mouse strains. The
Clcn4
gene was found to map to the X chromosome in the wild Mediterrean mouse,
Mus spretus
but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.</description><subject>Agriculture</subject><subject>Amino Acid Sequence</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chloride Channels - genetics</subject><subject>Chromosome Mapping</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Gene Rearrangement</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Muridae</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><subject>Vertebrata</subject><subject>X Chromosome</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0L9P3DAUwHGrAgEFlu5IHlCHVinPdmI7I722_NAhFm6OfM7zYZTYVzsZ6F9fozsxVer0LL2PnqUvIZ8YfGMg9FXYgG6bqpbyAzlhTS0rppg-KG-QrKpByGPyMecXAFbXoI_IkZIK6laekNUP7xwmDBO1zymOMcfRDHSI1gz-j5l8DDQ6Oj0jXQw21HSDAakP9GHONG8TTmWa0NNFo74vr-Q9Hb3FM3LozJDxfD9PyerXz6fFbbV8vLlbXC8rK5SeKtugQNlrC1oycK5vES23HAyXHEBqzdeuSESmeYOOaVdzgaIXDRqGjTgln3d3tyn-njFP3eizxWEwAeOcO6UaULJV_4VM6pKNQ4FfdtCmmHNC122TH0167Rh0b7G7XeyuxC74Yn91Xo_Yv9N93bK_3O9NLj1dMsH6_M6EZLpteWFfd6z09GGDqXuJcwol3L8-_QsqKZMg</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Rugarli, Elena I.</creator><creator>Adler, David A.</creator><creator>Borsani, Giuseppe</creator><creator>Tsuchiya, Karen</creator><creator>Franco, Brunella</creator><creator>Hauge, Xueya</creator><creator>Disteche, Christine</creator><creator>Chapman, Verne</creator><creator>Ballabio, Andrea</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice</title><author>Rugarli, Elena I. ; Adler, David A. ; Borsani, Giuseppe ; Tsuchiya, Karen ; Franco, Brunella ; Hauge, Xueya ; Disteche, Christine ; Chapman, Verne ; Ballabio, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-c5e3e6d8c08610ffd9eec2c20a262006882bf378ee1825ef18f423e3d35ea1e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Agriculture</topic><topic>Amino Acid Sequence</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Chloride Channels - genetics</topic><topic>Chromosome Mapping</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Gene Rearrangement</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Muridae</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><topic>Vertebrata</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rugarli, Elena I.</creatorcontrib><creatorcontrib>Adler, David A.</creatorcontrib><creatorcontrib>Borsani, Giuseppe</creatorcontrib><creatorcontrib>Tsuchiya, Karen</creatorcontrib><creatorcontrib>Franco, Brunella</creatorcontrib><creatorcontrib>Hauge, Xueya</creatorcontrib><creatorcontrib>Disteche, Christine</creatorcontrib><creatorcontrib>Chapman, Verne</creatorcontrib><creatorcontrib>Ballabio, Andrea</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rugarli, Elena I.</au><au>Adler, David A.</au><au>Borsani, Giuseppe</au><au>Tsuchiya, Karen</au><au>Franco, Brunella</au><au>Hauge, Xueya</au><au>Disteche, Christine</au><au>Chapman, Verne</au><au>Ballabio, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>10</volume><issue>4</issue><spage>466</spage><epage>471</epage><pages>466-471</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>We report the unprecedented finding of a gene with a different map position in two mouse strains. The
Clcn4
gene was found to map to the X chromosome in the wild Mediterrean mouse,
Mus spretus
but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>7670496</pmid><doi>10.1038/ng0895-466</doi><tpages>6</tpages></addata></record> |
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| ispartof | Nature genetics, 1995-08, Vol.10 (4), p.466-471 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_77507697 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Base Sequence Biological and medical sciences Biological Evolution Biomedical and Life Sciences Biomedicine Cancer Research Chloride Channels - genetics Chromosome Mapping Classical genetics, quantitative genetics, hybrids DNA Primers Female Fundamental and applied biological sciences. Psychology Gene Function Gene Rearrangement Genetics of eukaryotes. Biological and molecular evolution Human Genetics Humans Male Mice Mice, Inbred C57BL Molecular Sequence Data Muridae Sequence Homology, Amino Acid Species Specificity Vertebrata X Chromosome |
| title | Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice |
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