Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase

Ornithine decarboxylase, a critical regulatory enzyme for polyamine biosynthesis, is highly inducible by growth-promoting stimuli in mouse epidermis but the enzyme level is only transiently elevated due to rapid turnover of the protein. Here we report that constitutive overexpression of the enzyme i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1995-10, Vol.55 (19), p.4205-4209
Hauptverfasser:	MEGOSH, L, GILMOUR, S. K, ROSSON, D, SOLER, A. P, BLESSING, M, SAWICKI, J. A, O'BRIEN, T. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Experimental skin tumors Female Male Medical sciences Mice Mice, Transgenic Molecular Sequence Data Ornithine Decarboxylase - genetics Ornithine Decarboxylase - physiology Skin - enzymology Skin Neoplasms - etiology Skin Neoplasms - genetics Tumors
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