Atrial fibrillation begets atrial fibrillation : a study in awake chronically instrumented goats
In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia. Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of both atria....
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1995-10, Vol.92 (7), p.1954-1968 |
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| container_end_page | 1968 |
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| container_issue | 7 |
| container_start_page | 1954 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 92 |
| creator | WIJFFELS, M. C. E. F KIRCHHOF, J. H. J DORLAND, R ALLESSIE, M. A |
| description | In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia.
Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of both atria. Two to 3 Weeks after implantation, the animals were connected to a fibrillation pacemaker which artificially maintained AF. Whereas during control episodes of AF were short lasting (6 +/- 3 seconds), artificial maintenance of AF resulted in a progressive increase in the duration of AF to become sustained (> 24 hours) after 7.1 +/- 4.8 days (10 of 11 goats). During the first 24 hours of AF the median fibrillation interval shortened from 145 +/- 18 to 108 +/- 8 ms and the inducibility of AF by a single premature stimulus increased from 24% to 76%. The atrial effective refractory period (AERP) shortened from 146 +/- 19 to 95 +/- 20 ms (-35%) (S1S1, 400 ms). At high pacing rates the shortening was less (-12%), pointing to a reversion of the normal adaptation of the AERP to heart rate. In 5 goats, after 2 to 4 weeks of AF, sinus rhythm was restored and all electrophysiological changes were found to be reversible within 1 week.
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF. All these changes were completely reversible within 1 week of sinus rhythm. |
| doi_str_mv | 10.1161/01.CIR.92.7.1954 |
| format | Article |
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Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of both atria. Two to 3 Weeks after implantation, the animals were connected to a fibrillation pacemaker which artificially maintained AF. Whereas during control episodes of AF were short lasting (6 +/- 3 seconds), artificial maintenance of AF resulted in a progressive increase in the duration of AF to become sustained (> 24 hours) after 7.1 +/- 4.8 days (10 of 11 goats). During the first 24 hours of AF the median fibrillation interval shortened from 145 +/- 18 to 108 +/- 8 ms and the inducibility of AF by a single premature stimulus increased from 24% to 76%. The atrial effective refractory period (AERP) shortened from 146 +/- 19 to 95 +/- 20 ms (-35%) (S1S1, 400 ms). At high pacing rates the shortening was less (-12%), pointing to a reversion of the normal adaptation of the AERP to heart rate. In 5 goats, after 2 to 4 weeks of AF, sinus rhythm was restored and all electrophysiological changes were found to be reversible within 1 week.
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF. All these changes were completely reversible within 1 week of sinus rhythm.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.92.7.1954</identifier><identifier>PMID: 7671380</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Atrial Fibrillation - etiology ; Atrial Fibrillation - physiopathology ; Atrial Function - physiology ; Biological and medical sciences ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Consciousness ; Electrocardiography ; Electrophysiology ; Goats - physiology ; Heart ; Heart Conduction System - physiopathology ; Medical sciences ; Pacemaker, Artificial ; Refractory Period, Electrophysiological - physiology ; Time Factors</subject><ispartof>Circulation (New York, N.Y.), 1995-10, Vol.92 (7), p.1954-1968</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Oct 1, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-99e892010a7db83c974780f9f91ca0b37c3aed196e4f4e1eee069fa45142a0c3</citedby><cites>FETCH-LOGICAL-c391t-99e892010a7db83c974780f9f91ca0b37c3aed196e4f4e1eee069fa45142a0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,3676,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3673813$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7671380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WIJFFELS, M. C. E. F</creatorcontrib><creatorcontrib>KIRCHHOF, J. H. J</creatorcontrib><creatorcontrib>DORLAND, R</creatorcontrib><creatorcontrib>ALLESSIE, M. A</creatorcontrib><title>Atrial fibrillation begets atrial fibrillation : a study in awake chronically instrumented goats</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia.
Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of both atria. Two to 3 Weeks after implantation, the animals were connected to a fibrillation pacemaker which artificially maintained AF. Whereas during control episodes of AF were short lasting (6 +/- 3 seconds), artificial maintenance of AF resulted in a progressive increase in the duration of AF to become sustained (> 24 hours) after 7.1 +/- 4.8 days (10 of 11 goats). During the first 24 hours of AF the median fibrillation interval shortened from 145 +/- 18 to 108 +/- 8 ms and the inducibility of AF by a single premature stimulus increased from 24% to 76%. The atrial effective refractory period (AERP) shortened from 146 +/- 19 to 95 +/- 20 ms (-35%) (S1S1, 400 ms). At high pacing rates the shortening was less (-12%), pointing to a reversion of the normal adaptation of the AERP to heart rate. In 5 goats, after 2 to 4 weeks of AF, sinus rhythm was restored and all electrophysiological changes were found to be reversible within 1 week.
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF. All these changes were completely reversible within 1 week of sinus rhythm.</description><subject>Animals</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Function - physiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiology. Vascular system</subject><subject>Consciousness</subject><subject>Electrocardiography</subject><subject>Electrophysiology</subject><subject>Goats - physiology</subject><subject>Heart</subject><subject>Heart Conduction System - physiopathology</subject><subject>Medical sciences</subject><subject>Pacemaker, Artificial</subject><subject>Refractory Period, Electrophysiological - physiology</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1r3DAQhkVJSbdp770URAi92Z2RZMvKLSz9CAQKJXdVlseJEq-dSDIh_75asuRQehpm3meG4WHsE0KN2OJXwHp7-bs2otY1mka9YRtshKpUI80R2wCAqbQU4h17n9JdaVupm2N2rFuNsoMN-3ORY3ATH0MfwzS5HJaZ93RDOXH3n-icO57yOjzzMHP35O6J-9u4zMG7adoPU47rjuZMA79ZXE4f2NvRTYk-HuoJu_7-7Xr7s7r69eNye3FVeWkwV8ZQZwQgOD30nfRGK93BaEaD3kEvtZeOBjQtqVEREhG0ZnSqQSUceHnCvrycfYjL40op211InsrbMy1rslo3oFqlCnj6D3i3rHEur1mBQgtQsi0QvEA-LilFGu1DDDsXny2C3Yu3gLaIt0ZYbffiy8rnw92139HwunAwXfKzQ-5ScTVGN_uQXjHZatmhlH8BRY6LeQ</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>WIJFFELS, M. C. E. F</creator><creator>KIRCHHOF, J. H. J</creator><creator>DORLAND, R</creator><creator>ALLESSIE, M. A</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>Atrial fibrillation begets atrial fibrillation : a study in awake chronically instrumented goats</title><author>WIJFFELS, M. C. E. F ; KIRCHHOF, J. H. J ; DORLAND, R ; ALLESSIE, M. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-99e892010a7db83c974780f9f91ca0b37c3aed196e4f4e1eee069fa45142a0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Function - physiology</topic><topic>Biological and medical sciences</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiology. Vascular system</topic><topic>Consciousness</topic><topic>Electrocardiography</topic><topic>Electrophysiology</topic><topic>Goats - physiology</topic><topic>Heart</topic><topic>Heart Conduction System - physiopathology</topic><topic>Medical sciences</topic><topic>Pacemaker, Artificial</topic><topic>Refractory Period, Electrophysiological - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WIJFFELS, M. C. E. F</creatorcontrib><creatorcontrib>KIRCHHOF, J. H. J</creatorcontrib><creatorcontrib>DORLAND, R</creatorcontrib><creatorcontrib>ALLESSIE, M. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial fibrillation begets atrial fibrillation : a study in awake chronically instrumented goats</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>92</volume><issue>7</issue><spage>1954</spage><epage>1968</epage><pages>1954-1968</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia.
Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of both atria. Two to 3 Weeks after implantation, the animals were connected to a fibrillation pacemaker which artificially maintained AF. Whereas during control episodes of AF were short lasting (6 +/- 3 seconds), artificial maintenance of AF resulted in a progressive increase in the duration of AF to become sustained (> 24 hours) after 7.1 +/- 4.8 days (10 of 11 goats). During the first 24 hours of AF the median fibrillation interval shortened from 145 +/- 18 to 108 +/- 8 ms and the inducibility of AF by a single premature stimulus increased from 24% to 76%. The atrial effective refractory period (AERP) shortened from 146 +/- 19 to 95 +/- 20 ms (-35%) (S1S1, 400 ms). At high pacing rates the shortening was less (-12%), pointing to a reversion of the normal adaptation of the AERP to heart rate. In 5 goats, after 2 to 4 weeks of AF, sinus rhythm was restored and all electrophysiological changes were found to be reversible within 1 week.
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF. All these changes were completely reversible within 1 week of sinus rhythm.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7671380</pmid><doi>10.1161/01.CIR.92.7.1954</doi><tpages>15</tpages></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 1995-10, Vol.92 (7), p.1954-1968 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Atrial Fibrillation - etiology Atrial Fibrillation - physiopathology Atrial Function - physiology Biological and medical sciences Cardiac dysrhythmias Cardiac Pacing, Artificial Cardiology. Vascular system Consciousness Electrocardiography Electrophysiology Goats - physiology Heart Heart Conduction System - physiopathology Medical sciences Pacemaker, Artificial Refractory Period, Electrophysiological - physiology Time Factors |
| title | Atrial fibrillation begets atrial fibrillation : a study in awake chronically instrumented goats |
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