Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells (∗)

Escape from negative growth regulation by transforming growth factor β (TGF-β) as a result of the loss of TGF-β type II receptor (RII) expression has been found to be associated with the replication error (RER) colorectal cancer genotype, which is characteristic of hereditary nonpolyposis colorectal...

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Veröffentlicht in:	The Journal of biological chemistry 1995-09, Vol.270 (37), p.22044-22049
Hauptverfasser:	Wang, Jing, Sun, LuZhe, Myeroff, Lois, Wang, Xiaofan, Gentry, Larry E., Yang, Junhua, Liang, Jiurong, Zborowska, Elizabeth, Markowitz, Sanford, Willson, James K.V., Brattain, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Line Clone Cells Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology DNA Primers Gene Expression Humans Mice Mice, Nude Molecular Sequence Data Mutation Phenotype Polymerase Chain Reaction Protein-Serine-Threonine Kinases Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta - biosynthesis Receptors, Transforming Growth Factor beta - genetics Recombinant Proteins - analysis Recombinant Proteins - biosynthesis RNA, Messenger - analysis RNA, Messenger - biosynthesis Transfection Transforming Growth Factor beta - analysis Transforming Growth Factor beta - biosynthesis Transplantation, Heterologous Tumor Cells, Cultured
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