Induction of New Proteins by Gamma Interferon in Cultured Human Keratinocytes

Human epidermal keratinocytes incubated with recombinant gamma interferon (r-IFN-γ) show, on two-dimensional gel electrophoresis, both the appearance of new proteins and the loss of others. Among [35S]methionine-labeled proteins, which are induced in an actinomycin- or α-amanitin-sensitive manner, i...

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Veröffentlicht in:	Journal of investigative dermatology 1987-05, Vol.88 (5), p.602-610
Hauptverfasser:	Mansbridge, Jonathan N., Nickoloff, Brian J., Morhenn, Vera B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Chemical Phenomena Chemistry Chromatography, Gel Dermatology DNA Epidermal Cells Epidermis Epidermis - metabolism Fibroblasts Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology gamma -Interferon Gel electrophoresis Glycosylation Histocompatibility antigen HLA Humans Interferon Type I - pharmacology Interferon-gamma - pharmacology Keratinocytes Keratins Macromolecular Substances - biosynthesis Membrane Proteins - biosynthesis Molecular Weight Osmolar Concentration Phosphorylation Protein biosynthesis RNA RNA - biosynthesis Skin Sound Time Factors Transcription Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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