Requirement of MIP-1α for an Inflammatory Response to Viral Infection

Macrophage inflammatory protein-1α (MIP-1α) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1α had been disrupted. Homozygous MIP-1α mutant (-/-) mice were resistant to Coxsackievirus...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-09, Vol.269 (5230), p.1583-1585
Hauptverfasser:	Cook, Donald N., Beck, Melinda A., Coffman, Thomas M., Kirby, Suzanne L., Sheridan, John F., Pragnell, Ian B., Smithies, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antibodies, Viral - blood B lymphocytes B-Lymphocytes - immunology Base Sequence Biological and medical sciences Chemokine CCL4 Chemokines coxsackievirus Coxsackievirus Infections - immunology Coxsackievirus Infections - virology Cytokines - genetics Cytokines - physiology Enterovirus B, Human - growth & development Enterovirus B, Human - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Targeting Genetic loci Hematopoiesis Immunobiology Infections Inflammation Inflammation mediators Influenza A virus - growth & development Influenza A virus - immunology influenza virus Lymphocyte Activation Macrophage Inflammatory Proteins Mediators Mice Mice, Inbred C57BL Miscellaneous Molecular Sequence Data Monokines - genetics Monokines - physiology Myocarditis Myocarditis - immunology Myocarditis - virology Neutralization Tests Orthomyxoviridae Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Physiological aspects Regulatory factors and their cellular receptors Stem Cells T lymphocytes T-Lymphocytes - immunology Virus diseases Viruses
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