Telomerase Activity in Small-Cell and Non–Small-Cell Lung Cancers

Background:Telomerase is an enzyme that adds hexameric TTAGGG nucleotide repeats onto the ends of vertebrate chromosomal DNAs (i.e., telomeres) to compensate for losses that occur with each round of DNA replication. Somatic cells do not have telomerase activity and stop dividing when the telomeric e...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1995-06, Vol.87 (12), p.895-902
Hauptverfasser:	Hiyama, Keiko, Hiyama, Eiso, Ishioka, Shinichi, Yamakido, Michio, Inai, Kouki, Gazdar, Adi F., Piatyszek, Mieczyslaw A., Shay, Jerry W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Small Cell - enzymology Carcinoma, Small Cell - secondary Cellular biology DNA Nucleotidylexotransferase - genetics DNA Nucleotidylexotransferase - metabolism DNA, Neoplasm - genetics Enzymes Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Lung - enzymology Lung cancer Lung Neoplasms - enzymology Lung Neoplasms - pathology Medical research Medical sciences Molecular Sequence Data Pneumology Repetitive Sequences, Nucleic Acid Telomere - enzymology Telomere - genetics Tumors of the respiratory system and mediastinum
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