Nitric oxide-containing nerves in bowel segments of patients with Hirschsprung's disease
To assess the role of nerves that synthesize nitric oxide (NO) in Hirschsprung's Disease (HD), the authors studied the distribution of the enzyme NADPH diaphorase (NADPHd) in normal and diseased bowel segments. In the proximal (ganglionic) segment of the colon, NADPHd-positive neurons were pres...
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| Veröffentlicht in: | Journal of pediatric surgery 1995-06, Vol.30 (6), p.818-822 |
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| creator | Hanani, Menachem Louzon, Vered Udassin, Raphael Freund, Herbert R Karmeli, Fanny Rachmilewitz, Daniel |
| description | To assess the role of nerves that synthesize nitric oxide (NO) in Hirschsprung's Disease (HD), the authors studied the distribution of the enzyme NADPH diaphorase (NADPHd) in normal and diseased bowel segments. In the proximal (ganglionic) segment of the colon, NADPHd-positive neurons were present in both myenteric and submucosal plexuses. In the distal involved colonic segments from HD patients, the typical pattern of the neuronal network was completely missing in the regions of the two plexuses; instead, only disorganized NADPHd-positive nerve fibers were present and NADPHd-reactive neurons were absent. Mucosal NO synthase activity was 2.76 ± 0.38 nmol/g/min in the proximal segment and only 0.83 ± 0.49 nmol/g/min in the distal segment (
P < .05, N = 3). |
| doi_str_mv | 10.1016/0022-3468(95)90756-4 |
| format | Article |
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P < .05, N = 3).</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Colon - enzymology</subject><subject>Colon - innervation</subject><subject>Colon - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hirschsprung Disease - pathology</subject><subject>Hirschsprung Disease - physiopathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Intestinal Mucosa - innervation</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>NADPH Dehydrogenase - metabolism</subject><subject>Neurons - enzymology</subject><subject>Nitric Oxide - physiology</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanani, Menachem</creatorcontrib><creatorcontrib>Louzon, Vered</creatorcontrib><creatorcontrib>Udassin, Raphael</creatorcontrib><creatorcontrib>Freund, Herbert R</creatorcontrib><creatorcontrib>Karmeli, Fanny</creatorcontrib><creatorcontrib>Rachmilewitz, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanani, Menachem</au><au>Louzon, Vered</au><au>Udassin, Raphael</au><au>Freund, Herbert R</au><au>Karmeli, Fanny</au><au>Rachmilewitz, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide-containing nerves in bowel segments of patients with Hirschsprung's disease</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>30</volume><issue>6</issue><spage>818</spage><epage>822</epage><pages>818-822</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><coden>JPDSA3</coden><abstract>To assess the role of nerves that synthesize nitric oxide (NO) in Hirschsprung's Disease (HD), the authors studied the distribution of the enzyme NADPH diaphorase (NADPHd) in normal and diseased bowel segments. In the proximal (ganglionic) segment of the colon, NADPHd-positive neurons were present in both myenteric and submucosal plexuses. In the distal involved colonic segments from HD patients, the typical pattern of the neuronal network was completely missing in the regions of the two plexuses; instead, only disorganized NADPHd-positive nerve fibers were present and NADPHd-reactive neurons were absent. Mucosal NO synthase activity was 2.76 ± 0.38 nmol/g/min in the proximal segment and only 0.83 ± 0.49 nmol/g/min in the distal segment (
P < .05, N = 3).</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>7666315</pmid><doi>10.1016/0022-3468(95)90756-4</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Child, Preschool Colon - enzymology Colon - innervation Colon - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Hirschsprung Disease - pathology Hirschsprung Disease - physiopathology Humans Infant Intestinal Mucosa - enzymology Intestinal Mucosa - innervation Intestinal Mucosa - pathology Male Medical sciences NADPH Dehydrogenase - metabolism Neurons - enzymology Nitric Oxide - physiology Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Nitric oxide-containing nerves in bowel segments of patients with Hirschsprung's disease |
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