Positional Distribution of Stearic Acid and Oleic Acid in a Triacylglycerol and Dietary Calcium Concentration Determines the Apparent Absorption of these Fatty Acids in Rats
In this study the effect of the positional distribution of stearic acid (18:0) and oleic acid (18:1) in a triacylglycerol on absorption of fat, energy and nutrients was investigated in young rats. In addition the effect of dietary calcium on these variables was studied. Forty rats were fed purified...
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| Veröffentlicht in: | The Journal of nutrition 1995-09, Vol.125 (9), p.2379-2387 |
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| creator | Brink, Elizabeth J. Haddeman, Edward de Fouw, Nanneke J. Weststrate, Jan A. |
| description | In this study the effect of the positional distribution of stearic acid (18:0) and oleic acid (18:1) in a triacylglycerol on absorption of fat, energy and nutrients was investigated in young rats. In addition the effect of dietary calcium on these variables was studied. Forty rats were fed purified diets containing either a fat blend high in 2-oleoyl-distearate or a fat blend high in 1-oleoyl-distearate. Both diets were given at low (0.3 g/100 g) and high (1.0 g/100 g) dietary calcium concentrations. Total fat absorption, expressed as the percentage of fat intake, was significantly lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate at both dietary calcium concentrations. When expressed as absolute figures, the lower fat absorption in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate only reached statistical significance at the high dietary calcium concentration. The reduced absorption of total fat was mainly caused by the lower absorption of stearic acid. The percentage of, but not absolute, absorption of oleic acid and energy were lower in rats fed 2-oleoyl-distearate. Absolute and percentage of calcium absorption were lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate. Absolute and percentage of magnesium absorption were not significantly affected by the positional distribution of stearic acid and oleic acid in the triacylglycerol, but were decreased at a high dietary calcium concentration. We concluded that the lowered stearic acid absorption from 2-oleoyl-distearate compared with 1-oleoyl-distearate might have been due to the greater formation of insoluble calcium and magnesium soaps in the intestine. |
| doi_str_mv | 10.1093/jn/125.9.2379 |
| format | Article |
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In addition the effect of dietary calcium on these variables was studied. Forty rats were fed purified diets containing either a fat blend high in 2-oleoyl-distearate or a fat blend high in 1-oleoyl-distearate. Both diets were given at low (0.3 g/100 g) and high (1.0 g/100 g) dietary calcium concentrations. Total fat absorption, expressed as the percentage of fat intake, was significantly lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate at both dietary calcium concentrations. When expressed as absolute figures, the lower fat absorption in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate only reached statistical significance at the high dietary calcium concentration. The reduced absorption of total fat was mainly caused by the lower absorption of stearic acid. The percentage of, but not absolute, absorption of oleic acid and energy were lower in rats fed 2-oleoyl-distearate. Absolute and percentage of calcium absorption were lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate. Absolute and percentage of magnesium absorption were not significantly affected by the positional distribution of stearic acid and oleic acid in the triacylglycerol, but were decreased at a high dietary calcium concentration. We concluded that the lowered stearic acid absorption from 2-oleoyl-distearate compared with 1-oleoyl-distearate might have been due to the greater formation of insoluble calcium and magnesium soaps in the intestine.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/125.9.2379</identifier><identifier>PMID: 7666256</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Absorption ; Animals ; Biological and medical sciences ; Body Weight - physiology ; calcium ; Calcium - analysis ; Calcium - pharmacokinetics ; Calcium, Dietary - pharmacology ; Dose-Response Relationship, Drug ; Eating - physiology ; fat absorption ; Fatty Acids - pharmacokinetics ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Intestinal Mucosa - physiology ; Magnesium - analysis ; Magnesium - pharmacokinetics ; Male ; Nitrogen - analysis ; Nitrogen - pharmacokinetics ; Oleic Acid ; Oleic Acids - chemistry ; Phosphorus - analysis ; Phosphorus - pharmacokinetics ; positional fatty acid distribution ; Rats ; Rats, Wistar ; stearic acid ; Stearic Acids - chemistry ; Triglycerides - chemistry ; Triglycerides - pharmacokinetics ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 1995-09, Vol.125 (9), p.2379-2387</ispartof><rights>1995 American Society for Nutrition.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-6bc21c23a3ee3824e4e8ce818227faeeb6cd475336d2eb75c58d6d1e36e02b133</citedby><cites>FETCH-LOGICAL-c404t-6bc21c23a3ee3824e4e8ce818227faeeb6cd475336d2eb75c58d6d1e36e02b133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3665006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7666256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brink, Elizabeth J.</creatorcontrib><creatorcontrib>Haddeman, Edward</creatorcontrib><creatorcontrib>de Fouw, Nanneke J.</creatorcontrib><creatorcontrib>Weststrate, Jan A.</creatorcontrib><title>Positional Distribution of Stearic Acid and Oleic Acid in a Triacylglycerol and Dietary Calcium Concentration Determines the Apparent Absorption of these Fatty Acids in Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>In this study the effect of the positional distribution of stearic acid (18:0) and oleic acid (18:1) in a triacylglycerol on absorption of fat, energy and nutrients was investigated in young rats. In addition the effect of dietary calcium on these variables was studied. Forty rats were fed purified diets containing either a fat blend high in 2-oleoyl-distearate or a fat blend high in 1-oleoyl-distearate. Both diets were given at low (0.3 g/100 g) and high (1.0 g/100 g) dietary calcium concentrations. Total fat absorption, expressed as the percentage of fat intake, was significantly lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate at both dietary calcium concentrations. When expressed as absolute figures, the lower fat absorption in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate only reached statistical significance at the high dietary calcium concentration. The reduced absorption of total fat was mainly caused by the lower absorption of stearic acid. The percentage of, but not absolute, absorption of oleic acid and energy were lower in rats fed 2-oleoyl-distearate. Absolute and percentage of calcium absorption were lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate. Absolute and percentage of magnesium absorption were not significantly affected by the positional distribution of stearic acid and oleic acid in the triacylglycerol, but were decreased at a high dietary calcium concentration. We concluded that the lowered stearic acid absorption from 2-oleoyl-distearate compared with 1-oleoyl-distearate might have been due to the greater formation of insoluble calcium and magnesium soaps in the intestine.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>calcium</subject><subject>Calcium - analysis</subject><subject>Calcium - pharmacokinetics</subject><subject>Calcium, Dietary - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating - physiology</subject><subject>fat absorption</subject><subject>Fatty Acids - pharmacokinetics</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - physiology</subject><subject>Magnesium - analysis</subject><subject>Magnesium - pharmacokinetics</subject><subject>Male</subject><subject>Nitrogen - analysis</subject><subject>Nitrogen - pharmacokinetics</subject><subject>Oleic Acid</subject><subject>Oleic Acids - chemistry</subject><subject>Phosphorus - analysis</subject><subject>Phosphorus - pharmacokinetics</subject><subject>positional fatty acid distribution</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>stearic acid</subject><subject>Stearic Acids - chemistry</subject><subject>Triglycerides - chemistry</subject><subject>Triglycerides - pharmacokinetics</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS1EVYbCkiWSF6i7TP2TOMlyNEMBqVIrKGvLcW7AI8cOtoM0D9V3xJmZdsfKujqf7vE9B6EPlKwpafnN3t1QVq3bNeN1-wqtaFXSQlBCXqMVIYwVnArxBr2NcU8IoWXbXKLLWgjBKrFCTw8-mmS8UxbvTEzBdPMyYj_gHwlUMBpvtOmxcj2-t_A8GocVfgxG6YP9ZQ8agrdHZmcgqXDAW2W1mUe89U6DS0Edt-4gQRiNg4jTb8CbaVIhq3jTRR-mZ-MsRcC3KqXD0S0udt9Viu_QxaBshPfn9wr9vP38uP1a3N1_-bbd3BW6JGUqRKcZ1YwrDsAbVkIJjYaGNozVgwLohO7LuuJc9Ay6utJV04ueAhdAWEc5v0LXp71T8H9miEmOJmqwVjnwc5R1XeUsWZXB4gTq4GMMMMgpmDHfLymRSz1y72SuR7ZyqSfzH8-L526E_oU-95H1T2ddRa3sEJTTJr5gXIhsvGD1CYMcwl8DQUZtIAfdmwA6yd6b_3zgH5X5rVE</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Brink, Elizabeth J.</creator><creator>Haddeman, Edward</creator><creator>de Fouw, Nanneke J.</creator><creator>Weststrate, Jan A.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>Positional Distribution of Stearic Acid and Oleic Acid in a Triacylglycerol and Dietary Calcium Concentration Determines the Apparent Absorption of these Fatty Acids in Rats</title><author>Brink, Elizabeth J. ; Haddeman, Edward ; de Fouw, Nanneke J. ; Weststrate, Jan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-6bc21c23a3ee3824e4e8ce818227faeeb6cd475336d2eb75c58d6d1e36e02b133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>calcium</topic><topic>Calcium - analysis</topic><topic>Calcium - pharmacokinetics</topic><topic>Calcium, Dietary - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating - physiology</topic><topic>fat absorption</topic><topic>Fatty Acids - pharmacokinetics</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - physiology</topic><topic>Magnesium - analysis</topic><topic>Magnesium - pharmacokinetics</topic><topic>Male</topic><topic>Nitrogen - analysis</topic><topic>Nitrogen - pharmacokinetics</topic><topic>Oleic Acid</topic><topic>Oleic Acids - chemistry</topic><topic>Phosphorus - analysis</topic><topic>Phosphorus - pharmacokinetics</topic><topic>positional fatty acid distribution</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>stearic acid</topic><topic>Stearic Acids - chemistry</topic><topic>Triglycerides - chemistry</topic><topic>Triglycerides - pharmacokinetics</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brink, Elizabeth J.</creatorcontrib><creatorcontrib>Haddeman, Edward</creatorcontrib><creatorcontrib>de Fouw, Nanneke J.</creatorcontrib><creatorcontrib>Weststrate, Jan A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brink, Elizabeth J.</au><au>Haddeman, Edward</au><au>de Fouw, Nanneke J.</au><au>Weststrate, Jan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positional Distribution of Stearic Acid and Oleic Acid in a Triacylglycerol and Dietary Calcium Concentration Determines the Apparent Absorption of these Fatty Acids in Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>125</volume><issue>9</issue><spage>2379</spage><epage>2387</epage><pages>2379-2387</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>In this study the effect of the positional distribution of stearic acid (18:0) and oleic acid (18:1) in a triacylglycerol on absorption of fat, energy and nutrients was investigated in young rats. In addition the effect of dietary calcium on these variables was studied. Forty rats were fed purified diets containing either a fat blend high in 2-oleoyl-distearate or a fat blend high in 1-oleoyl-distearate. Both diets were given at low (0.3 g/100 g) and high (1.0 g/100 g) dietary calcium concentrations. Total fat absorption, expressed as the percentage of fat intake, was significantly lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate at both dietary calcium concentrations. When expressed as absolute figures, the lower fat absorption in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate only reached statistical significance at the high dietary calcium concentration. The reduced absorption of total fat was mainly caused by the lower absorption of stearic acid. The percentage of, but not absolute, absorption of oleic acid and energy were lower in rats fed 2-oleoyl-distearate. Absolute and percentage of calcium absorption were lower in rats fed 2-oleoyl-distearate compared with 1-oleoyl-distearate. Absolute and percentage of magnesium absorption were not significantly affected by the positional distribution of stearic acid and oleic acid in the triacylglycerol, but were decreased at a high dietary calcium concentration. We concluded that the lowered stearic acid absorption from 2-oleoyl-distearate compared with 1-oleoyl-distearate might have been due to the greater formation of insoluble calcium and magnesium soaps in the intestine.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>7666256</pmid><doi>10.1093/jn/125.9.2379</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorption Animals Biological and medical sciences Body Weight - physiology calcium Calcium - analysis Calcium - pharmacokinetics Calcium, Dietary - pharmacology Dose-Response Relationship, Drug Eating - physiology fat absorption Fatty Acids - pharmacokinetics Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - physiology Magnesium - analysis Magnesium - pharmacokinetics Male Nitrogen - analysis Nitrogen - pharmacokinetics Oleic Acid Oleic Acids - chemistry Phosphorus - analysis Phosphorus - pharmacokinetics positional fatty acid distribution Rats Rats, Wistar stearic acid Stearic Acids - chemistry Triglycerides - chemistry Triglycerides - pharmacokinetics Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Positional Distribution of Stearic Acid and Oleic Acid in a Triacylglycerol and Dietary Calcium Concentration Determines the Apparent Absorption of these Fatty Acids in Rats |
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