Therapy of Relapsing Clostridium difficile Associated Diarrhea and Colitis with the Combination of Vancomycin and Rifampin
Seven patients with multiple bacteriologic and symptomatic relapses of Clostridium difficile-associated diarrhea and/or colitis were treated with vancomycin and rifampin in combination. Diarrhea and abdominal pain promptly resolved in all, and neither C. difficile nor its toxin could be recovered fr...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1987-04, Vol.9 (2), p.155-159 |
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| container_title | Journal of clinical gastroenterology |
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| creator | Buggy, Brian P Fekety, Robert Silva, Joseph |
| description | Seven patients with multiple bacteriologic and symptomatic relapses of Clostridium difficile-associated diarrhea and/or colitis were treated with vancomycin and rifampin in combination. Diarrhea and abdominal pain promptly resolved in all, and neither C. difficile nor its toxin could be recovered from their stools shortly after therapy. However, stools of all patients subsequently became culture-positive for C. difficile and occasionally had demonstrable cytotoxin. Except in one instance following oral antibiotic use, all patients remained free of symptoms. Resistance to either vancomycin or rifampin was not encountered. Biotyping of isolates with clostridial bacteriophages and bacteriocins suggested true relapse with the same organism in all patients studied, rather than reinfection with another strain. Vancomycin and rifampin in combination appear to be useful in the therapy of relapsing antibiotic-associated diarrhea due to C. difficile. |
| doi_str_mv | 10.1097/00004836-198704000-00009 |
| format | Article |
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Diarrhea and abdominal pain promptly resolved in all, and neither C. difficile nor its toxin could be recovered from their stools shortly after therapy. However, stools of all patients subsequently became culture-positive for C. difficile and occasionally had demonstrable cytotoxin. Except in one instance following oral antibiotic use, all patients remained free of symptoms. Resistance to either vancomycin or rifampin was not encountered. Biotyping of isolates with clostridial bacteriophages and bacteriocins suggested true relapse with the same organism in all patients studied, rather than reinfection with another strain. Vancomycin and rifampin in combination appear to be useful in the therapy of relapsing antibiotic-associated diarrhea due to C. difficile.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-198704000-00009</identifier><identifier>PMID: 3571889</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Clostridium - drug effects ; Clostridium Infections - drug therapy ; Colitis - drug therapy ; Colitis - etiology ; Diarrhea - drug therapy ; Diarrhea - etiology ; Drug Therapy, Combination ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Middle Aged ; Pharmacology. Drug treatments ; Recurrence ; Rifampin - administration & dosage ; Rifampin - therapeutic use ; Toxicity: digestive system ; Vancomycin - administration & dosage ; Vancomycin - therapeutic use</subject><ispartof>Journal of clinical gastroenterology, 1987-04, Vol.9 (2), p.155-159</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4139-1caa793becc9ad4b0d70a5daac7de4de9ac307cea48cec2ab8ad22f68dd1343d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8370227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3571889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buggy, Brian P</creatorcontrib><creatorcontrib>Fekety, Robert</creatorcontrib><creatorcontrib>Silva, Joseph</creatorcontrib><title>Therapy of Relapsing Clostridium difficile Associated Diarrhea and Colitis with the Combination of Vancomycin and Rifampin</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>Seven patients with multiple bacteriologic and symptomatic relapses of Clostridium difficile-associated diarrhea and/or colitis were treated with vancomycin and rifampin in combination. Diarrhea and abdominal pain promptly resolved in all, and neither C. difficile nor its toxin could be recovered from their stools shortly after therapy. However, stools of all patients subsequently became culture-positive for C. difficile and occasionally had demonstrable cytotoxin. Except in one instance following oral antibiotic use, all patients remained free of symptoms. Resistance to either vancomycin or rifampin was not encountered. Biotyping of isolates with clostridial bacteriophages and bacteriocins suggested true relapse with the same organism in all patients studied, rather than reinfection with another strain. Vancomycin and rifampin in combination appear to be useful in the therapy of relapsing antibiotic-associated diarrhea due to C. difficile.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Clostridium - drug effects</subject><subject>Clostridium Infections - drug therapy</subject><subject>Colitis - drug therapy</subject><subject>Colitis - etiology</subject><subject>Diarrhea - drug therapy</subject><subject>Diarrhea - etiology</subject><subject>Drug Therapy, Combination</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Recurrence</subject><subject>Rifampin - administration & dosage</subject><subject>Rifampin - therapeutic use</subject><subject>Toxicity: digestive system</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - therapeutic use</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EKtvCT0DyAXFLseNsbR-rpXxIlZCqwjWa2BN2wImDnWi1_Hq83WVv-GL5nWfG8mPGuBTXUlj9XpTVGHVTSWu0aMqpOkT2GVvJtbJVLZR8zlZC2roS2oqX7DLnn0JIrZS8YBdqraUxdsX-PG4xwbTnsecPGGDKNP7gmxDznMjTMnBPfU-OAvLbnKMjmNHzDwQpbRE4jJ5vYqCZMt_RvOXzFkswdDTCTHE8zP0Oo4vD3tH4hD9QD8NE4yv2ooeQ8fVpv2LfPt49bj5X918_fdnc3leukeUp0gFoqzp0zoJvOuG1gLUHcNpj49GCU0I7hMY4dDV0Bnxd9zfGe6ka5dUVe3ecO6X4e8E8twNlhyHAiHHJrdaNtUbKApoj6FLMOWHfTokGSPtWivagvf2nvT1rf4psaX1zumPpBvTnxpPnUn97qkN2EPpUlFA-Y0ZpUde6YM0R28UwY8q_wrLD1BbRYd62__t09Rdx6J0k</recordid><startdate>198704</startdate><enddate>198704</enddate><creator>Buggy, Brian P</creator><creator>Fekety, Robert</creator><creator>Silva, Joseph</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198704</creationdate><title>Therapy of Relapsing Clostridium difficile Associated Diarrhea and Colitis with the Combination of Vancomycin and Rifampin</title><author>Buggy, Brian P ; Fekety, Robert ; Silva, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4139-1caa793becc9ad4b0d70a5daac7de4de9ac307cea48cec2ab8ad22f68dd1343d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Clostridium - drug effects</topic><topic>Clostridium Infections - drug therapy</topic><topic>Colitis - drug therapy</topic><topic>Colitis - etiology</topic><topic>Diarrhea - drug therapy</topic><topic>Diarrhea - etiology</topic><topic>Drug Therapy, Combination</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Recurrence</topic><topic>Rifampin - administration & dosage</topic><topic>Rifampin - therapeutic use</topic><topic>Toxicity: digestive system</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buggy, Brian P</creatorcontrib><creatorcontrib>Fekety, Robert</creatorcontrib><creatorcontrib>Silva, Joseph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buggy, Brian P</au><au>Fekety, Robert</au><au>Silva, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapy of Relapsing Clostridium difficile Associated Diarrhea and Colitis with the Combination of Vancomycin and Rifampin</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1987-04</date><risdate>1987</risdate><volume>9</volume><issue>2</issue><spage>155</spage><epage>159</epage><pages>155-159</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><coden>JCGADC</coden><abstract>Seven patients with multiple bacteriologic and symptomatic relapses of Clostridium difficile-associated diarrhea and/or colitis were treated with vancomycin and rifampin in combination. Diarrhea and abdominal pain promptly resolved in all, and neither C. difficile nor its toxin could be recovered from their stools shortly after therapy. However, stools of all patients subsequently became culture-positive for C. difficile and occasionally had demonstrable cytotoxin. Except in one instance following oral antibiotic use, all patients remained free of symptoms. Resistance to either vancomycin or rifampin was not encountered. Biotyping of isolates with clostridial bacteriophages and bacteriocins suggested true relapse with the same organism in all patients studied, rather than reinfection with another strain. Vancomycin and rifampin in combination appear to be useful in the therapy of relapsing antibiotic-associated diarrhea due to C. difficile.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>3571889</pmid><doi>10.1097/00004836-198704000-00009</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1987-04, Vol.9 (2), p.155-159 |
| issn | 0192-0790 1539-2031 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Clostridium - drug effects Clostridium Infections - drug therapy Colitis - drug therapy Colitis - etiology Diarrhea - drug therapy Diarrhea - etiology Drug Therapy, Combination Drug toxicity and drugs side effects treatment Female Humans Male Medical sciences Microbial Sensitivity Tests Middle Aged Pharmacology. Drug treatments Recurrence Rifampin - administration & dosage Rifampin - therapeutic use Toxicity: digestive system Vancomycin - administration & dosage Vancomycin - therapeutic use |
| title | Therapy of Relapsing Clostridium difficile Associated Diarrhea and Colitis with the Combination of Vancomycin and Rifampin |
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