Mitotic counts in follicular lymphomas
Increased mitotic activity is associated with significantly shorter patient survival in some of the subtypes of diffuse non-Hodgkin's lymphomas. This study on 105 cases of follicular lymphoma was undertaken to determine the clinical significance of mitotic activity in follicular lymphomas. For...
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| Veröffentlicht in: | Human pathology 1987-05, Vol.18 (5), p.502-505 |
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| container_title | Human pathology |
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| creator | Ellison, Douglas J. Nathwani, Bharat N. Metter, Gerald E. Turner, Roderick R. Burke, Jerome S. Miller, Thomas P. Mann, Risa B. Barcos, Maurice Kjeldsberg, Carl R. Winberg, Carl D. Whitcomb, Clarence C. |
| description | Increased mitotic activity is associated with significantly shorter patient survival in some of the subtypes of diffuse non-Hodgkin's lymphomas. This study on 105 cases of follicular lymphoma was undertaken to determine the clinical significance of mitotic activity in follicular lymphomas. For each case, two pathologists independently counted mitotic figures in 20 random high-power fields. The difference of the average mitotic counts over 20 high-power fields for the two pathologists showed a Gaussian distribution with a median difference of −0.26 counts per high-power field and a standard error of 0.10 per cent. In 94 cases (91 per cent), the difference was less than two mitotic counts per high-power field, indicating good interobserver agreement. There was a statistically significant difference in mitotic counts between subtypes of follicular lymphoma as well as a gradient among subtypes, with the lowest mitotic activity in the poorly differentiated lymphocytic subtype and highest in the undifferentiated subtype. A multivariate statistical analysis of clinical and pathologic variables showed that mitotic figures were not of prognostic significance. |
| doi_str_mv | 10.1016/S0046-8177(87)80035-7 |
| format | Article |
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This study on 105 cases of follicular lymphoma was undertaken to determine the clinical significance of mitotic activity in follicular lymphomas. For each case, two pathologists independently counted mitotic figures in 20 random high-power fields. The difference of the average mitotic counts over 20 high-power fields for the two pathologists showed a Gaussian distribution with a median difference of −0.26 counts per high-power field and a standard error of 0.10 per cent. In 94 cases (91 per cent), the difference was less than two mitotic counts per high-power field, indicating good interobserver agreement. There was a statistically significant difference in mitotic counts between subtypes of follicular lymphoma as well as a gradient among subtypes, with the lowest mitotic activity in the poorly differentiated lymphocytic subtype and highest in the undifferentiated subtype. A multivariate statistical analysis of clinical and pathologic variables showed that mitotic figures were not of prognostic significance.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(87)80035-7</identifier><identifier>PMID: 3570281</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Humans ; Lymphoma, Non-Hodgkin - pathology ; Mitosis</subject><ispartof>Human pathology, 1987-05, Vol.18 (5), p.502-505</ispartof><rights>1987 W. B. Saunders Co. 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This study on 105 cases of follicular lymphoma was undertaken to determine the clinical significance of mitotic activity in follicular lymphomas. For each case, two pathologists independently counted mitotic figures in 20 random high-power fields. The difference of the average mitotic counts over 20 high-power fields for the two pathologists showed a Gaussian distribution with a median difference of −0.26 counts per high-power field and a standard error of 0.10 per cent. In 94 cases (91 per cent), the difference was less than two mitotic counts per high-power field, indicating good interobserver agreement. There was a statistically significant difference in mitotic counts between subtypes of follicular lymphoma as well as a gradient among subtypes, with the lowest mitotic activity in the poorly differentiated lymphocytic subtype and highest in the undifferentiated subtype. A multivariate statistical analysis of clinical and pathologic variables showed that mitotic figures were not of prognostic significance.</description><subject>Humans</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Mitosis</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotVZ_QmFWRRejN5PnrESKL6i4UNchk0kwMjOpyYzQf-_Ulm6FC3dxz7mH8yE0x3CNAfObNwDKc4mFuJTiSgIQlosjNMWMFLkkZXGMpgfJKTpL6QsAY0bZBE0IE1BIPEWLF9-H3pvMhKHrU-a7zIWm8WZodMyaTbv-DK1O5-jE6SbZi_2eoY-H-_flU756fXxe3q1yQzj0OcE1hYrwkjNauXoMca4soMQOU8DW6qp2HCpZSigKXmspSkeFsdhygQtWkRla7P6uY_gebOpV65OxTaM7G4akhKAllcBGIdsJTQwpRevUOvpWx43CoLZ81B8ftS2v5DhbPkqMvvk-YKhaWx9ceyDj_XZ3t2PLH2-jSsbbztjaR2t6VQf_T8IvmbFzbw</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Ellison, Douglas J.</creator><creator>Nathwani, Bharat N.</creator><creator>Metter, Gerald E.</creator><creator>Turner, Roderick R.</creator><creator>Burke, Jerome S.</creator><creator>Miller, Thomas P.</creator><creator>Mann, Risa B.</creator><creator>Barcos, Maurice</creator><creator>Kjeldsberg, Carl R.</creator><creator>Winberg, Carl D.</creator><creator>Whitcomb, Clarence C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870501</creationdate><title>Mitotic counts in follicular lymphomas</title><author>Ellison, Douglas J. ; Nathwani, Bharat N. ; Metter, Gerald E. ; Turner, Roderick R. ; Burke, Jerome S. ; Miller, Thomas P. ; Mann, Risa B. ; Barcos, Maurice ; Kjeldsberg, Carl R. ; Winberg, Carl D. ; Whitcomb, Clarence C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-31d40b369654bfd570ff92091f1401eeabdf60b8980226da879f47ce1e67125b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Humans</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Mitosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellison, Douglas J.</creatorcontrib><creatorcontrib>Nathwani, Bharat N.</creatorcontrib><creatorcontrib>Metter, Gerald E.</creatorcontrib><creatorcontrib>Turner, Roderick R.</creatorcontrib><creatorcontrib>Burke, Jerome S.</creatorcontrib><creatorcontrib>Miller, Thomas P.</creatorcontrib><creatorcontrib>Mann, Risa B.</creatorcontrib><creatorcontrib>Barcos, Maurice</creatorcontrib><creatorcontrib>Kjeldsberg, Carl R.</creatorcontrib><creatorcontrib>Winberg, Carl D.</creatorcontrib><creatorcontrib>Whitcomb, Clarence C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellison, Douglas J.</au><au>Nathwani, Bharat N.</au><au>Metter, Gerald E.</au><au>Turner, Roderick R.</au><au>Burke, Jerome S.</au><au>Miller, Thomas P.</au><au>Mann, Risa B.</au><au>Barcos, Maurice</au><au>Kjeldsberg, Carl R.</au><au>Winberg, Carl D.</au><au>Whitcomb, Clarence C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitotic counts in follicular lymphomas</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>18</volume><issue>5</issue><spage>502</spage><epage>505</epage><pages>502-505</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><abstract>Increased mitotic activity is associated with significantly shorter patient survival in some of the subtypes of diffuse non-Hodgkin's lymphomas. This study on 105 cases of follicular lymphoma was undertaken to determine the clinical significance of mitotic activity in follicular lymphomas. For each case, two pathologists independently counted mitotic figures in 20 random high-power fields. The difference of the average mitotic counts over 20 high-power fields for the two pathologists showed a Gaussian distribution with a median difference of −0.26 counts per high-power field and a standard error of 0.10 per cent. In 94 cases (91 per cent), the difference was less than two mitotic counts per high-power field, indicating good interobserver agreement. There was a statistically significant difference in mitotic counts between subtypes of follicular lymphoma as well as a gradient among subtypes, with the lowest mitotic activity in the poorly differentiated lymphocytic subtype and highest in the undifferentiated subtype. 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| language | eng |
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| subjects | Humans Lymphoma, Non-Hodgkin - pathology Mitosis |
| title | Mitotic counts in follicular lymphomas |
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