Detection and characterization of seven novel protein S (PROS) gene lesions : evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy

The molecular genetic analysis of protein S deficiency has been hampered by the complexity of the protein S (PROS) gene and by the existence of a homologous pseudogene. In an attempt to overcome these problems, a reverse transcript-polymerase chain reaction (RT-PCR) mutation screening procedure was...

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