Comparison of the Pharmacokinetics of Two Nicotine Transdermal Systems: Nicoderm and Habitrol
This randomized, crossover study compared the nicotine and cotinine pharmacokinetic parameters and plasma concentration profiles of two different nicotine transdermal products: Nicoderm (Alza, Palo Alto, CA; and Marion Merrell Dow, Kansas City, MO) and Habitrol (Basel Pharmaceuticals, Summit, NJ). T...
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| Veröffentlicht in: | Journal of clinical pharmacology 1995-05, Vol.35 (5), p.493-498 |
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| container_end_page | 498 |
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| container_title | Journal of clinical pharmacology |
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| creator | Gupta, Suneel K. Okerholm, Richard A. Eller, Mark Wei, Greg Rolf, Clyde N. Gorsline, Jane |
| description | This randomized, crossover study compared the nicotine and cotinine pharmacokinetic parameters and plasma concentration profiles of two different nicotine transdermal products: Nicoderm (Alza, Palo Alto, CA; and Marion Merrell Dow, Kansas City, MO) and Habitrol (Basel Pharmaceuticals, Summit, NJ). The two treatments were randomly assigned to each of 24 male smokers and worn for 24 hours each day for 5 days, with a 6‐day washout between treatments. Plasma nicotine and cotinine concentrations were measured on day 1 and day 5 of each treatment. Mean delivered dose differed significantly between products, and the two products were not bioequivalent. The Nicoderm system provided higher mean plasma nicotine concentrations, particularly during the first 8 hours after system application. The mean steady state Cmax, AUC, and degree of fluctuation (DF) values were significantly greater for the Nicoderm system than for Habitrol. The mean nicotine tmax value for the Nicoderm system was significantly shorter (P < .001) than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC values and plasma concentrations were significantly lower for Habitrol than for the Nicoderm system. The incidence of adverse events was similar for both products. |
| doi_str_mv | 10.1002/j.1552-4604.1995.tb04093.x |
| format | Article |
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The two treatments were randomly assigned to each of 24 male smokers and worn for 24 hours each day for 5 days, with a 6‐day washout between treatments. Plasma nicotine and cotinine concentrations were measured on day 1 and day 5 of each treatment. Mean delivered dose differed significantly between products, and the two products were not bioequivalent. The Nicoderm system provided higher mean plasma nicotine concentrations, particularly during the first 8 hours after system application. The mean steady state Cmax, AUC, and degree of fluctuation (DF) values were significantly greater for the Nicoderm system than for Habitrol. The mean nicotine tmax value for the Nicoderm system was significantly shorter (P < .001) than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC values and plasma concentrations were significantly lower for Habitrol than for the Nicoderm system. 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The two treatments were randomly assigned to each of 24 male smokers and worn for 24 hours each day for 5 days, with a 6‐day washout between treatments. Plasma nicotine and cotinine concentrations were measured on day 1 and day 5 of each treatment. Mean delivered dose differed significantly between products, and the two products were not bioequivalent. The Nicoderm system provided higher mean plasma nicotine concentrations, particularly during the first 8 hours after system application. The mean steady state Cmax, AUC, and degree of fluctuation (DF) values were significantly greater for the Nicoderm system than for Habitrol. The mean nicotine tmax value for the Nicoderm system was significantly shorter (P < .001) than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC values and plasma concentrations were significantly lower for Habitrol than for the Nicoderm system. The incidence of adverse events was similar for both products.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cotinine - blood</subject><subject>Cotinine - pharmacokinetics</subject><subject>Cross-Over Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nicotine - blood</subject><subject>Nicotine - pharmacokinetics</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF9v0zAUxS0EGmXwEZAihHhL8H_HewIqtgLTGFDEE7Icx9bcJXGxU6399jg06jtPts4599yrHwCvEKwQhPjtpkKM4ZJySCskJavGBlIoSbV_BBYn6zFYQChRiQWET8GzlDYQIk4ZOgNngjNRU7kAv5eh3-roUxiK4Irxzha3dzr22oR7P9jRmzTp64dQ3HgTxqwV66iH1Noc6oofhzTaPl38cyet0ENbrHTjxxi65-CJ012yL-b3HPy8_Lhersrrr1eflu-vS0MYISU3QrLGcm6Fq41EWGIphGsbjiirOc2XOsMxl9hQ17RE1K2ADDdWoLbWTpNz8ObYu43hz86mUfU-Gdt1erBhl5QQVGIKRQ5eHIMmhpSidWobfa_jQSGoJrZqoyaAagKoJrZqZqv2efjlvGXX9LY9jc4ws_969nUyunMZk_HpFCOMU85xjr07xh58Zw__cYD6vLxdTd9cUR4rfKa_P1XoeK-4IIKpXzdXql5_-f6NXgr1gfwF3GOl7A</recordid><startdate>199505</startdate><enddate>199505</enddate><creator>Gupta, Suneel K.</creator><creator>Okerholm, Richard A.</creator><creator>Eller, Mark</creator><creator>Wei, Greg</creator><creator>Rolf, Clyde N.</creator><creator>Gorsline, Jane</creator><general>Blackwell Publishing Ltd</general><general>Sage Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199505</creationdate><title>Comparison of the Pharmacokinetics of Two Nicotine Transdermal Systems: Nicoderm and Habitrol</title><author>Gupta, Suneel K. ; Okerholm, Richard A. ; Eller, Mark ; Wei, Greg ; Rolf, Clyde N. ; Gorsline, Jane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-6c795be66e7f8c91292977fdb6145864849fc62692c4fbd378d7052be71d8afa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cotinine - blood</topic><topic>Cotinine - pharmacokinetics</topic><topic>Cross-Over Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nicotine - blood</topic><topic>Nicotine - pharmacokinetics</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Suneel K.</creatorcontrib><creatorcontrib>Okerholm, Richard A.</creatorcontrib><creatorcontrib>Eller, Mark</creatorcontrib><creatorcontrib>Wei, Greg</creatorcontrib><creatorcontrib>Rolf, Clyde N.</creatorcontrib><creatorcontrib>Gorsline, Jane</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Suneel K.</au><au>Okerholm, Richard A.</au><au>Eller, Mark</au><au>Wei, Greg</au><au>Rolf, Clyde N.</au><au>Gorsline, Jane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the Pharmacokinetics of Two Nicotine Transdermal Systems: Nicoderm and Habitrol</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1995-05</date><risdate>1995</risdate><volume>35</volume><issue>5</issue><spage>493</spage><epage>498</epage><pages>493-498</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><coden>JCPCBR</coden><abstract>This randomized, crossover study compared the nicotine and cotinine pharmacokinetic parameters and plasma concentration profiles of two different nicotine transdermal products: Nicoderm (Alza, Palo Alto, CA; and Marion Merrell Dow, Kansas City, MO) and Habitrol (Basel Pharmaceuticals, Summit, NJ). The two treatments were randomly assigned to each of 24 male smokers and worn for 24 hours each day for 5 days, with a 6‐day washout between treatments. Plasma nicotine and cotinine concentrations were measured on day 1 and day 5 of each treatment. Mean delivered dose differed significantly between products, and the two products were not bioequivalent. The Nicoderm system provided higher mean plasma nicotine concentrations, particularly during the first 8 hours after system application. The mean steady state Cmax, AUC, and degree of fluctuation (DF) values were significantly greater for the Nicoderm system than for Habitrol. The mean nicotine tmax value for the Nicoderm system was significantly shorter (P < .001) than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC values and plasma concentrations were significantly lower for Habitrol than for the Nicoderm system. The incidence of adverse events was similar for both products.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7657849</pmid><doi>10.1002/j.1552-4604.1995.tb04093.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of clinical pharmacology, 1995-05, Vol.35 (5), p.493-498 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Administration, Cutaneous Adult Analysis of Variance Biological and medical sciences Cotinine - blood Cotinine - pharmacokinetics Cross-Over Studies Humans Male Medical sciences Middle Aged Nicotine - blood Nicotine - pharmacokinetics Tobacco, tobacco smoking Toxicology |
| title | Comparison of the Pharmacokinetics of Two Nicotine Transdermal Systems: Nicoderm and Habitrol |
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