Effectiveness of α, β-arteether in acute falciparum malaria
With the emergence of widespread chloroquine resistance and a world-wide scarcity of quinine, a search for newer antimalarial drugs has become imperative. Different derivatives of qinghaosu have been successfully tried, α, β-Arteether, an ethyl derivative of qinghaosu, was administered to 51 patient...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1995-05, Vol.89 (3), p.299-301 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Mishra, S.K. Asthana, O.P. Mohanty, S. Patnaik, J.K. Das, B.S. Srivastava, J.S. Satpathy, S.K. Dash, S. Rath, P.K. Varghese, K. |
| description | With the emergence of widespread chloroquine resistance and a world-wide scarcity of quinine, a search for newer antimalarial drugs has become imperative. Different derivatives of qinghaosu have been successfully tried, α, β-Arteether, an ethyl derivative of qinghaosu, was administered to 51 patients with
Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1–4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52·04 h (standard deviation 27·09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with
P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences, α-β Arteether was a safe, effective and convenient drug for treating
P. falciparum malaria. This is the first clinical study with arteether in falciparum malaria. |
| doi_str_mv | 10.1016/0035-9203(95)90550-2 |
| format | Article |
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Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1–4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52·04 h (standard deviation 27·09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with
P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences, α-β Arteether was a safe, effective and convenient drug for treating
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Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1–4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52·04 h (standard deviation 27·09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with
P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences, α-β Arteether was a safe, effective and convenient drug for treating
P. falciparum malaria. This is the first clinical study with arteether in falciparum malaria.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimalarials - therapeutic use</subject><subject>Antiparasitic agents</subject><subject>Artemisinins</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>India</subject><subject>malaria</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Plasmodium falciparum</topic><topic>Sesquiterpenes - therapeutic use</topic><topic>Tropical medicine</topic><topic>β-arteether</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, S.K.</creatorcontrib><creatorcontrib>Asthana, O.P.</creatorcontrib><creatorcontrib>Mohanty, S.</creatorcontrib><creatorcontrib>Patnaik, J.K.</creatorcontrib><creatorcontrib>Das, B.S.</creatorcontrib><creatorcontrib>Srivastava, J.S.</creatorcontrib><creatorcontrib>Satpathy, S.K.</creatorcontrib><creatorcontrib>Dash, S.</creatorcontrib><creatorcontrib>Rath, P.K.</creatorcontrib><creatorcontrib>Varghese, K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishra, S.K.</au><au>Asthana, O.P.</au><au>Mohanty, S.</au><au>Patnaik, J.K.</au><au>Das, B.S.</au><au>Srivastava, J.S.</au><au>Satpathy, S.K.</au><au>Dash, S.</au><au>Rath, P.K.</au><au>Varghese, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of α, β-arteether in acute falciparum malaria</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>89</volume><issue>3</issue><spage>299</spage><epage>301</epage><pages>299-301</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>With the emergence of widespread chloroquine resistance and a world-wide scarcity of quinine, a search for newer antimalarial drugs has become imperative. Different derivatives of qinghaosu have been successfully tried, α, β-Arteether, an ethyl derivative of qinghaosu, was administered to 51 patients with
Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1–4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52·04 h (standard deviation 27·09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with
P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences, α-β Arteether was a safe, effective and convenient drug for treating
P. falciparum malaria. This is the first clinical study with arteether in falciparum malaria.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7660441</pmid><doi>10.1016/0035-9203(95)90550-2</doi><tpages>3</tpages></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1995-05, Vol.89 (3), p.299-301 |
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| subjects | Adolescent Adult Aged Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - therapeutic use Antiparasitic agents Artemisinins Biological and medical sciences Female Humans India malaria Malaria, Falciparum - drug therapy Male Medical sciences Middle Aged Pharmacology. Drug treatments Plasmodium falciparum Sesquiterpenes - therapeutic use Tropical medicine β-arteether |
| title | Effectiveness of α, β-arteether in acute falciparum malaria |
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