Separate mechanisms for central osmotically-induced drinking and vasopressin release in minipigs
Operant drinking and lysine vasopressin (LVP) release were investigated in minipigs following intracerebroventricular (ICV) injections of hypertonic equiosmolar (1.4 osM) solutions of NaCl and of sucrose and mannitol dissolved in 0.15 M NaCl or water, and of urea dissolved in 0.15 M NaCl. Hypertonic...
Gespeichert in:
| Veröffentlicht in: | Physiology & behavior 1987, Vol.39 (4), p.541-545 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 545 |
|---|---|
| container_issue | 4 |
| container_start_page | 541 |
| container_title | Physiology & behavior |
| container_volume | 39 |
| creator | Thornton, S.N. Forsling, M.L. Baldwin, B.A. Delaney, C.E. |
| description | Operant drinking and lysine vasopressin (LVP) release were investigated in minipigs following intracerebroventricular (ICV) injections of hypertonic equiosmolar (1.4 osM) solutions of NaCl and of sucrose and mannitol dissolved in 0.15 M NaCl or water, and of urea dissolved in 0.15 M NaCl. Hypertonic (0.74 M) NaCl produced significant drinking and LVP release in all minipigs tested whereas hypertonic equiosmolar (1.4 osM) solutions of sucrose and mannitol induced only drinking. Mannitol, both with and without NaCl, was more effective than sucrose. Hypertonic urea was ineffective both as an osmotic dipsogen and at stimulating the release of LVP. These results suggest that two independent mechanisms could be involved in drinking and LVP responses to ICV administration of hypertonic solutions in minipigs. |
| doi_str_mv | 10.1016/0031-9384(87)90387-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77491562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0031938487903878</els_id><sourcerecordid>77491562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-d58f70127bb040c88e52375555fa4841cc05020e050d147883889de8b76be86a3</originalsourceid><addsrcrecordid>eNqFkU-LFDEQxYMo67j6BUQhBxE9tCaddKfmIsjiP1jwsC54i-mkeox2p3tTPQv77U07wxy1DklB_epRvMfYMyneSCHbt0IoWW0V6FdgXm-FAlPBPbaRYFTVCPP9PtuckIfsEdEvUUppdcbOlBRGCLlhP65wdtktyEf0P12KNBLvp8w9piW7gU80Tkv0bhjuqpjC3mPgIcf0O6YddynwW0fTnJEoJp5xQEfISzvGFOe4o8fsQe8GwifH_5xdf_zw7eJzdfn105eL95eV16pdqtBAb4SsTdcJLTwANrUyTaneadDSe9GIWmB5g9QGQAFsA0Jn2g6hdeqcvTzoznm62SMtdozkcRhcwmlP1hi9lU1b_xeUum1lDaqA-gD6PBFl7O2c4-jynZXCrgnY1V672mvB2L8JWChrz4_6-27EcFo6Wl7mL45zR8XWPrvkI52wcmaj6lXm6QHr3WTdLhfk-qpE22i9nvbuMMTi6G3EbMlHTCWbmNEvNkzx30f-AZ1CqgU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14661283</pqid></control><display><type>article</type><title>Separate mechanisms for central osmotically-induced drinking and vasopressin release in minipigs</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Thornton, S.N. ; Forsling, M.L. ; Baldwin, B.A. ; Delaney, C.E.</creator><creatorcontrib>Thornton, S.N. ; Forsling, M.L. ; Baldwin, B.A. ; Delaney, C.E.</creatorcontrib><description>Operant drinking and lysine vasopressin (LVP) release were investigated in minipigs following intracerebroventricular (ICV) injections of hypertonic equiosmolar (1.4 osM) solutions of NaCl and of sucrose and mannitol dissolved in 0.15 M NaCl or water, and of urea dissolved in 0.15 M NaCl. Hypertonic (0.74 M) NaCl produced significant drinking and LVP release in all minipigs tested whereas hypertonic equiosmolar (1.4 osM) solutions of sucrose and mannitol induced only drinking. Mannitol, both with and without NaCl, was more effective than sucrose. Hypertonic urea was ineffective both as an osmotic dipsogen and at stimulating the release of LVP. These results suggest that two independent mechanisms could be involved in drinking and LVP responses to ICV administration of hypertonic solutions in minipigs.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(87)90387-8</identifier><identifier>PMID: 3107001</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; CENTRAL NERVOUS SYSTEM ; CERDO ; COMPORTAMIENTO INGESTION LIQUIDOS ; Drinking ; Drinking - drug effects ; DRINKING HABITS ; Female ; Fundamental and applied biological sciences. Psychology ; HABITUDE DE BOISSON ; Hypertonic Solutions - pharmacology ; Injections, Intraventricular ; Intracerebroventricular ; Lypressin - blood ; Male ; Mannitol ; Metabolisms and neurohumoral controls ; Minipigs ; Osmolar Concentration ; Osmoreceptor ; OSMOTIC PRESSURE ; PEPTIDE ; PEPTIDES ; PEPTIDOS ; PORCIN ; PRESION OSMOTICA ; PRESSION OSMOTIQUE ; Saline Solution, Hypertonic - pharmacology ; SISTEMA NERVIOSO CENTRAL ; SODIO ; SODIUM ; Sodium - blood ; Sodium Chloride - pharmacology ; Sodium receptor ; Sucrose ; SWINE ; Swine, Miniature - physiology ; SYSTEME NERVEUX CENTRAL ; Urea ; Vasopressin ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Water and mineral metabolism. Osmoregulation. Acidobasic balance</subject><ispartof>Physiology & behavior, 1987, Vol.39 (4), p.541-545</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-d58f70127bb040c88e52375555fa4841cc05020e050d147883889de8b76be86a3</citedby><cites>FETCH-LOGICAL-c436t-d58f70127bb040c88e52375555fa4841cc05020e050d147883889de8b76be86a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0031-9384(87)90387-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7495328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3107001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thornton, S.N.</creatorcontrib><creatorcontrib>Forsling, M.L.</creatorcontrib><creatorcontrib>Baldwin, B.A.</creatorcontrib><creatorcontrib>Delaney, C.E.</creatorcontrib><title>Separate mechanisms for central osmotically-induced drinking and vasopressin release in minipigs</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Operant drinking and lysine vasopressin (LVP) release were investigated in minipigs following intracerebroventricular (ICV) injections of hypertonic equiosmolar (1.4 osM) solutions of NaCl and of sucrose and mannitol dissolved in 0.15 M NaCl or water, and of urea dissolved in 0.15 M NaCl. Hypertonic (0.74 M) NaCl produced significant drinking and LVP release in all minipigs tested whereas hypertonic equiosmolar (1.4 osM) solutions of sucrose and mannitol induced only drinking. Mannitol, both with and without NaCl, was more effective than sucrose. Hypertonic urea was ineffective both as an osmotic dipsogen and at stimulating the release of LVP. These results suggest that two independent mechanisms could be involved in drinking and LVP responses to ICV administration of hypertonic solutions in minipigs.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>CERDO</subject><subject>COMPORTAMIENTO INGESTION LIQUIDOS</subject><subject>Drinking</subject><subject>Drinking - drug effects</subject><subject>DRINKING HABITS</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HABITUDE DE BOISSON</subject><subject>Hypertonic Solutions - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Intracerebroventricular</subject><subject>Lypressin - blood</subject><subject>Male</subject><subject>Mannitol</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Minipigs</subject><subject>Osmolar Concentration</subject><subject>Osmoreceptor</subject><subject>OSMOTIC PRESSURE</subject><subject>PEPTIDE</subject><subject>PEPTIDES</subject><subject>PEPTIDOS</subject><subject>PORCIN</subject><subject>PRESION OSMOTICA</subject><subject>PRESSION OSMOTIQUE</subject><subject>Saline Solution, Hypertonic - pharmacology</subject><subject>SISTEMA NERVIOSO CENTRAL</subject><subject>SODIO</subject><subject>SODIUM</subject><subject>Sodium - blood</subject><subject>Sodium Chloride - pharmacology</subject><subject>Sodium receptor</subject><subject>Sucrose</subject><subject>SWINE</subject><subject>Swine, Miniature - physiology</subject><subject>SYSTEME NERVEUX CENTRAL</subject><subject>Urea</subject><subject>Vasopressin</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Water and mineral metabolism. Osmoregulation. Acidobasic balance</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6BUQhBxE9tCaddKfmIsjiP1jwsC54i-mkeox2p3tTPQv77U07wxy1DklB_epRvMfYMyneSCHbt0IoWW0V6FdgXm-FAlPBPbaRYFTVCPP9PtuckIfsEdEvUUppdcbOlBRGCLlhP65wdtktyEf0P12KNBLvp8w9piW7gU80Tkv0bhjuqpjC3mPgIcf0O6YddynwW0fTnJEoJp5xQEfISzvGFOe4o8fsQe8GwifH_5xdf_zw7eJzdfn105eL95eV16pdqtBAb4SsTdcJLTwANrUyTaneadDSe9GIWmB5g9QGQAFsA0Jn2g6hdeqcvTzoznm62SMtdozkcRhcwmlP1hi9lU1b_xeUum1lDaqA-gD6PBFl7O2c4-jynZXCrgnY1V672mvB2L8JWChrz4_6-27EcFo6Wl7mL45zR8XWPrvkI52wcmaj6lXm6QHr3WTdLhfk-qpE22i9nvbuMMTi6G3EbMlHTCWbmNEvNkzx30f-AZ1CqgU</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Thornton, S.N.</creator><creator>Forsling, M.L.</creator><creator>Baldwin, B.A.</creator><creator>Delaney, C.E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Separate mechanisms for central osmotically-induced drinking and vasopressin release in minipigs</title><author>Thornton, S.N. ; Forsling, M.L. ; Baldwin, B.A. ; Delaney, C.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-d58f70127bb040c88e52375555fa4841cc05020e050d147883889de8b76be86a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>CERDO</topic><topic>COMPORTAMIENTO INGESTION LIQUIDOS</topic><topic>Drinking</topic><topic>Drinking - drug effects</topic><topic>DRINKING HABITS</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HABITUDE DE BOISSON</topic><topic>Hypertonic Solutions - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Intracerebroventricular</topic><topic>Lypressin - blood</topic><topic>Male</topic><topic>Mannitol</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Minipigs</topic><topic>Osmolar Concentration</topic><topic>Osmoreceptor</topic><topic>OSMOTIC PRESSURE</topic><topic>PEPTIDE</topic><topic>PEPTIDES</topic><topic>PEPTIDOS</topic><topic>PORCIN</topic><topic>PRESION OSMOTICA</topic><topic>PRESSION OSMOTIQUE</topic><topic>Saline Solution, Hypertonic - pharmacology</topic><topic>SISTEMA NERVIOSO CENTRAL</topic><topic>SODIO</topic><topic>SODIUM</topic><topic>Sodium - blood</topic><topic>Sodium Chloride - pharmacology</topic><topic>Sodium receptor</topic><topic>Sucrose</topic><topic>SWINE</topic><topic>Swine, Miniature - physiology</topic><topic>SYSTEME NERVEUX CENTRAL</topic><topic>Urea</topic><topic>Vasopressin</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Water and mineral metabolism. Osmoregulation. Acidobasic balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thornton, S.N.</creatorcontrib><creatorcontrib>Forsling, M.L.</creatorcontrib><creatorcontrib>Baldwin, B.A.</creatorcontrib><creatorcontrib>Delaney, C.E.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thornton, S.N.</au><au>Forsling, M.L.</au><au>Baldwin, B.A.</au><au>Delaney, C.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Separate mechanisms for central osmotically-induced drinking and vasopressin release in minipigs</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1987</date><risdate>1987</risdate><volume>39</volume><issue>4</issue><spage>541</spage><epage>545</epage><pages>541-545</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Operant drinking and lysine vasopressin (LVP) release were investigated in minipigs following intracerebroventricular (ICV) injections of hypertonic equiosmolar (1.4 osM) solutions of NaCl and of sucrose and mannitol dissolved in 0.15 M NaCl or water, and of urea dissolved in 0.15 M NaCl. Hypertonic (0.74 M) NaCl produced significant drinking and LVP release in all minipigs tested whereas hypertonic equiosmolar (1.4 osM) solutions of sucrose and mannitol induced only drinking. Mannitol, both with and without NaCl, was more effective than sucrose. Hypertonic urea was ineffective both as an osmotic dipsogen and at stimulating the release of LVP. These results suggest that two independent mechanisms could be involved in drinking and LVP responses to ICV administration of hypertonic solutions in minipigs.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3107001</pmid><doi>10.1016/0031-9384(87)90387-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 1987, Vol.39 (4), p.541-545 |
| issn | 0031-9384 1873-507X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77491562 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences CENTRAL NERVOUS SYSTEM CERDO COMPORTAMIENTO INGESTION LIQUIDOS Drinking Drinking - drug effects DRINKING HABITS Female Fundamental and applied biological sciences. Psychology HABITUDE DE BOISSON Hypertonic Solutions - pharmacology Injections, Intraventricular Intracerebroventricular Lypressin - blood Male Mannitol Metabolisms and neurohumoral controls Minipigs Osmolar Concentration Osmoreceptor OSMOTIC PRESSURE PEPTIDE PEPTIDES PEPTIDOS PORCIN PRESION OSMOTICA PRESSION OSMOTIQUE Saline Solution, Hypertonic - pharmacology SISTEMA NERVIOSO CENTRAL SODIO SODIUM Sodium - blood Sodium Chloride - pharmacology Sodium receptor Sucrose SWINE Swine, Miniature - physiology SYSTEME NERVEUX CENTRAL Urea Vasopressin Vertebrates: anatomy and physiology, studies on body, several organs or systems Water and mineral metabolism. Osmoregulation. Acidobasic balance |
| title | Separate mechanisms for central osmotically-induced drinking and vasopressin release in minipigs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T14%3A39%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Separate%20mechanisms%20for%20central%20osmotically-induced%20drinking%20and%20vasopressin%20release%20in%20minipigs&rft.jtitle=Physiology%20&%20behavior&rft.au=Thornton,%20S.N.&rft.date=1987&rft.volume=39&rft.issue=4&rft.spage=541&rft.epage=545&rft.pages=541-545&rft.issn=0031-9384&rft.eissn=1873-507X&rft_id=info:doi/10.1016/0031-9384(87)90387-8&rft_dat=%3Cproquest_cross%3E77491562%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14661283&rft_id=info:pmid/3107001&rft_els_id=0031938487903878&rfr_iscdi=true |