Pyrophosphate Stimulates Wild-type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channels (∗)

A unique feature of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel is regulation by ATP through the two cytoplasmic nucleotide-binding domains (NBDs). To better understand this process, we asked how channel activity is affected by inorganic pyrophosphate (PPi), a compound...

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Veröffentlicht in:	The Journal of biological chemistry 1995-09, Vol.270 (35), p.20466-20472
Hauptverfasser:	Carson, Mark R., Winter, Michael C., Travis, Sue M., Welsh, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Cell Line Cell Membrane - physiology Chloride Channels - drug effects Chloride Channels - physiology Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - pharmacology Cystic Fibrosis - genetics Cystic Fibrosis Transmembrane Conductance Regulator Diphosphates - pharmacology Epithelium - physiology Etidronic Acid - pharmacology HeLa Cells Humans Kinetics Mammary Glands, Animal Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Proteins - drug effects Membrane Proteins - genetics Membrane Proteins - physiology Mice Patch-Clamp Techniques Point Mutation Recombinant Proteins - biosynthesis Recombinant Proteins - drug effects Recombinant Proteins - metabolism Transfection
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