Influence of atrophy on the efficiency of muscle reinnervation

Influence of atrophy on the efficiency of muscle reinnervation

The effectiveness of motor reinnervation carried out after an interval of 20 days between nerve transection and reimplantation onto a foreign muscle was studied in the rat. Sixty days after reimplantation the compound action potential, the maximal indirect twitch and tetanic tensions, and weight los...

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Veröffentlicht in:Experimental neurology 1987-05, Vol.96 (2), p.248-252
Hauptverfasser: Brunetti, O., Carobi, C., Pazzaglia, U.
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials
Animals
Biological and medical sciences
Cranial nerves. Peripheral nerves. Autonomic nervous system
Male
Medical sciences
Muscle Contraction
Muscle Denervation
Muscles - innervation
Nerve Regeneration
Neurosurgery
Organ Size
Peripheral Nerves - physiology
Rats
Rats, Inbred Strains
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Zusammenfassung:The effectiveness of motor reinnervation carried out after an interval of 20 days between nerve transection and reimplantation onto a foreign muscle was studied in the rat. Sixty days after reimplantation the compound action potential, the maximal indirect twitch and tetanic tensions, and weight loss were evaluated. The functional data demonstrated an incomplete recovery which differed from the complete functional restoration observed in an acutely denervated muscle reinnervated with a chronically severed nerve. Time-dependent changes induced in the muscle by denervation seem therefore to influence the efficacy of motor reinnervation.
ISSN:0014-4886
1090-2430
DOI:10.1016/0014-4886(87)90043-4