CARBAZOMYCINS C, D, E AND F, MINOR COMPONENTS OF THE CARBAZOMYCIN COMPLEX
Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were eluc...
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| Veröffentlicht in: | Journal of antibiotics 1987/02/25, Vol.40(2), pp.157-164 |
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| container_end_page | 164 |
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| container_issue | 2 |
| container_start_page | 157 |
| container_title | Journal of antibiotics |
| container_volume | 40 |
| creator | NAID, TADJUDDIN KITAHARA, TOSHIHARU KANEDA, MIYUKI NAKAMURA, SHOSHIRO |
| description | Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were elucidated as 4-hydroxy-3, 6-dimethoxy-1, 2-dimethylcarbazole and 3, 4, 6-trimethoxy-1, 2-dimethylcarbazole, respectively, by spectroscopic and chemical means. The other components, V and VI, were found to contain an aldehyde function and were identified as carbazomycinal and 6-methoxycarbazomycinal, respectively. The antimicrobial activity of III and IV are also reported. |
| doi_str_mv | 10.7164/antibiotics.40.157 |
| format | Article |
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Among them, III and IV were shown to be new substances and their structures were elucidated as 4-hydroxy-3, 6-dimethoxy-1, 2-dimethylcarbazole and 3, 4, 6-trimethoxy-1, 2-dimethylcarbazole, respectively, by spectroscopic and chemical means. The other components, V and VI, were found to contain an aldehyde function and were identified as carbazomycinal and 6-methoxycarbazomycinal, respectively. The antimicrobial activity of III and IV are also reported.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.40.157</identifier><identifier>PMID: 3570964</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Anti-Bacterial Agents ; Antibacterial agents ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents ; Biological and medical sciences ; Biotechnology ; Carbazoles - isolation & purification ; Chemical Phenomena ; Chemistry, Physical ; Chromatography, Thin Layer ; Fundamental and applied biological sciences. Psychology ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmacology. Drug treatments ; Production of active biomolecules ; Streptomyces - analysis ; Structure-Activity Relationship</subject><ispartof>The Journal of Antibiotics, 1987/02/25, Vol.40(2), pp.157-164</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5577-9ee8389082e65b3637e96c15d80db2c68b4c3a828f413e4ddfdbf39a56435ac23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8216588$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3570964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAID, TADJUDDIN</creatorcontrib><creatorcontrib>KITAHARA, TOSHIHARU</creatorcontrib><creatorcontrib>KANEDA, MIYUKI</creatorcontrib><creatorcontrib>NAKAMURA, SHOSHIRO</creatorcontrib><title>CARBAZOMYCINS C, D, E AND F, MINOR COMPONENTS OF THE CARBAZOMYCIN COMPLEX</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were elucidated as 4-hydroxy-3, 6-dimethoxy-1, 2-dimethylcarbazole and 3, 4, 6-trimethoxy-1, 2-dimethylcarbazole, respectively, by spectroscopic and chemical means. The other components, V and VI, were found to contain an aldehyde function and were identified as carbazomycinal and 6-methoxycarbazomycinal, respectively. The antimicrobial activity of III and IV are also reported.</description><subject>Anti-Bacterial Agents</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Carbazoles - isolation & purification</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Chromatography, Thin Layer</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Production of active biomolecules</subject><subject>Streptomyces - analysis</subject><subject>Structure-Activity Relationship</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtP40AQhEcIBOHxB1ZCmgPiFId5T_sYjLNEJDaCIMFeRuPxeNfIeeBJDvvv12yiKJfuQ33V1SqEflAy0FSJO7tY10W9XNcuDAQZUKmPUI8C0IgKFR-jHiGMRgCMnKHzED4J4ZprOEWnXGoSK9FD42T4cj_8lU8_knH2ipM-fujjFA-zBzzq4-k4y19wkk-f8yzNZq84H-HZY4oPTf_lSfp-iU4q2wR_tdsX6G2UzpLHaJL_7FImkZNS6yj2HjjEBJhXsuCKax8rR2UJpCyYU1AIxy0wqATlXpRlVRYVj61UgkvrGL9At9u7q3b5tfFhbeZ1cL5p7MIvN8FoLQAgph3ItqBrlyG0vjKrtp7b9q-hxHz3Zw76M4KYrr_OdL27vinmvtxbdoV1-s1Ot8HZpmrtwtVhjwGjSgJ02NMW-wxr-9vvddt2YY0_TKaxgu90th3dE3vK_bGt8Qv-D9MEjuk</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>NAID, TADJUDDIN</creator><creator>KITAHARA, TOSHIHARU</creator><creator>KANEDA, MIYUKI</creator><creator>NAKAMURA, SHOSHIRO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>CARBAZOMYCINS C, D, E AND F, MINOR COMPONENTS OF THE CARBAZOMYCIN COMPLEX</title><author>NAID, TADJUDDIN ; KITAHARA, TOSHIHARU ; KANEDA, MIYUKI ; NAKAMURA, SHOSHIRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5577-9ee8389082e65b3637e96c15d80db2c68b4c3a828f413e4ddfdbf39a56435ac23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Anti-Bacterial Agents</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal Agents</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Carbazoles - isolation & purification</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Chromatography, Thin Layer</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Production of active biomolecules</topic><topic>Streptomyces - analysis</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAID, TADJUDDIN</creatorcontrib><creatorcontrib>KITAHARA, TOSHIHARU</creatorcontrib><creatorcontrib>KANEDA, MIYUKI</creatorcontrib><creatorcontrib>NAKAMURA, SHOSHIRO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAID, TADJUDDIN</au><au>KITAHARA, TOSHIHARU</au><au>KANEDA, MIYUKI</au><au>NAKAMURA, SHOSHIRO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CARBAZOMYCINS C, D, E AND F, MINOR COMPONENTS OF THE CARBAZOMYCIN COMPLEX</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1987</date><risdate>1987</risdate><volume>40</volume><issue>2</issue><spage>157</spage><epage>164</epage><pages>157-164</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Carbazomycins C (III), D (IV), E (V) and F (VI), the minor components of the carbazomycin complex, were isolated from the cultured broth of Streptoverticillium ehimense together with carbazomycins A (II) and B (I). Among them, III and IV were shown to be new substances and their structures were elucidated as 4-hydroxy-3, 6-dimethoxy-1, 2-dimethylcarbazole and 3, 4, 6-trimethoxy-1, 2-dimethylcarbazole, respectively, by spectroscopic and chemical means. The other components, V and VI, were found to contain an aldehyde function and were identified as carbazomycinal and 6-methoxycarbazomycinal, respectively. The antimicrobial activity of III and IV are also reported.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>3570964</pmid><doi>10.7164/antibiotics.40.157</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1987/02/25, Vol.40(2), pp.157-164 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77488891 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Anti-Bacterial Agents Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents Biological and medical sciences Biotechnology Carbazoles - isolation & purification Chemical Phenomena Chemistry, Physical Chromatography, Thin Layer Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Production of active biomolecules Streptomyces - analysis Structure-Activity Relationship |
| title | CARBAZOMYCINS C, D, E AND F, MINOR COMPONENTS OF THE CARBAZOMYCIN COMPLEX |
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