Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis: evidence that antibody modulation may cause protracted infection
The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers wit...
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| Veröffentlicht in: | Journal of hepatology 1987-02, Vol.4 (1), p.15-21 |
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| container_title | Journal of hepatology |
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| creator | PIGNATELLI, M WATERS, J LEVER, A IWARSON, S GERETY, R THOMAS, H. C |
| description | The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers with chronic hepatitis and can be blocked by monoclonal anti-HBc and anti-HBe. Passive immunisation of chimpanzees with monoclonal anti-HBc and anti-HBe offers no protection against HBV infection but in both cases leads to an unusually prolonged hepatitis probably by modulation of HBc and HBe antigen display on the hepatocytes. High-titre anti-HBc in the circulation of HBe antigen-positive patients probably modulates the former protein making HBe the important target antigen for cytotoxic T cells mediating liver damage in chronic carriers. These data also support the hypothesis that passive transfer of IgG anti-HBc across the placenta may be one major factor promoting development of persistent infection in neonates infected from carrier mothers. |
| doi_str_mv | 10.1016/S0168-8278(87)80004-1 |
| format | Article |
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These data also support the hypothesis that passive transfer of IgG anti-HBc across the placenta may be one major factor promoting development of persistent infection in neonates infected from carrier mothers.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(87)80004-1</identifier><identifier>PMID: 3494760</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Carrier State - immunology ; Hepatitis B - immunology ; Hepatitis B Antibodies - immunology ; Hepatitis B Core Antigens - immunology ; Hepatitis B e Antigens - immunology ; Hepatitis, Chronic - immunology ; Human viral diseases ; Humans ; Immunization, Passive ; Infectious diseases ; Liver - immunology ; Medical sciences ; Pan troglodytes ; T-Lymphocytes, Cytotoxic - immunology ; Viral diseases ; Viral hepatitis</subject><ispartof>Journal of hepatology, 1987-02, Vol.4 (1), p.15-21</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-d200514d4569a2b733cea03a04fa85b3eeb267bb4dcabcc199edb8f6922719d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8282133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3494760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PIGNATELLI, M</creatorcontrib><creatorcontrib>WATERS, J</creatorcontrib><creatorcontrib>LEVER, A</creatorcontrib><creatorcontrib>IWARSON, S</creatorcontrib><creatorcontrib>GERETY, R</creatorcontrib><creatorcontrib>THOMAS, H. C</creatorcontrib><title>Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis: evidence that antibody modulation may cause protracted infection</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers with chronic hepatitis and can be blocked by monoclonal anti-HBc and anti-HBe. Passive immunisation of chimpanzees with monoclonal anti-HBc and anti-HBe offers no protection against HBV infection but in both cases leads to an unusually prolonged hepatitis probably by modulation of HBc and HBe antigen display on the hepatocytes. High-titre anti-HBc in the circulation of HBe antigen-positive patients probably modulates the former protein making HBe the important target antigen for cytotoxic T cells mediating liver damage in chronic carriers. These data also support the hypothesis that passive transfer of IgG anti-HBc across the placenta may be one major factor promoting development of persistent infection in neonates infected from carrier mothers.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Carrier State - immunology</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B Antibodies - immunology</subject><subject>Hepatitis B Core Antigens - immunology</subject><subject>Hepatitis B e Antigens - immunology</subject><subject>Hepatitis, Chronic - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Infectious diseases</subject><subject>Liver - immunology</subject><subject>Medical sciences</subject><subject>Pan troglodytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1uFDEQhC1EFJbAI0TyASE4TPDfjj25JStIIkXKgcB11bZ7tEYz9mTsibIPwvvikFUuXYf6qtQqQk45O-OMt99-1mMaI7T5YvRXwxhTDX9DVrxlrGGt4m_J6hV5R97n_KcyknXqmBxL1SndshX5u9mXVNJTcPS-cTgMdMY8pZgx05Jo2SGNixswOZhy8HSaU8EQM009vb78TUOkbjenWPM7nKCEEvI5xcfgMTqseSgUYgk2-T0dk1-GyqRIR9hTB0vG_40zuIK-lvXonu0P5KiHIePHg56QXz--32-um9u7q5vNxW3jhNGl8YKxNVderdsOhNVSOgQmgakezNpKRCtaba3yDqxzvOvQW9O3nRCad76VJ-TzS2994mHBXLZjyM8rQMS05K3WyhjOZAVPD-BiR_TbaQ4jzPvtYcfqfzr4kB0M_QzRhfyKGWEEl1L-AzxIhik</recordid><startdate>19870201</startdate><enddate>19870201</enddate><creator>PIGNATELLI, M</creator><creator>WATERS, J</creator><creator>LEVER, A</creator><creator>IWARSON, S</creator><creator>GERETY, R</creator><creator>THOMAS, H. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis: evidence that antibody modulation may cause protracted infection</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>4</volume><issue>1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers with chronic hepatitis and can be blocked by monoclonal anti-HBc and anti-HBe. Passive immunisation of chimpanzees with monoclonal anti-HBc and anti-HBe offers no protection against HBV infection but in both cases leads to an unusually prolonged hepatitis probably by modulation of HBc and HBe antigen display on the hepatocytes. High-titre anti-HBc in the circulation of HBe antigen-positive patients probably modulates the former protein making HBe the important target antigen for cytotoxic T cells mediating liver damage in chronic carriers. These data also support the hypothesis that passive transfer of IgG anti-HBc across the placenta may be one major factor promoting development of persistent infection in neonates infected from carrier mothers.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>3494760</pmid><doi>10.1016/S0168-8278(87)80004-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 1987-02, Vol.4 (1), p.15-21 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antibodies, Monoclonal - immunology Biological and medical sciences Carrier State - immunology Hepatitis B - immunology Hepatitis B Antibodies - immunology Hepatitis B Core Antigens - immunology Hepatitis B e Antigens - immunology Hepatitis, Chronic - immunology Human viral diseases Humans Immunization, Passive Infectious diseases Liver - immunology Medical sciences Pan troglodytes T-Lymphocytes, Cytotoxic - immunology Viral diseases Viral hepatitis |
| title | Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis: evidence that antibody modulation may cause protracted infection |
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