Characterization of carrier-mediated transport systems for small neutral amino acids in human fibroblast lysosomes

Analog inhibition studies of the uptake of proline, serine, and threonine into human fibroblast lysosomes, purified on Percoll gradients, reveal the presence of three new transport systems. These systems fail to show the Na+ requirement usual for the plasma membrane. Proline uptake into fibroblast l...

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Veröffentlicht in:	The Journal of biological chemistry 1987-05, Vol.262 (13), p.6010-6017
Hauptverfasser:	Pisoni, R.L., Flickinger, K.S., Thoene, J.G., Christensen, H.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism amino acids Amino Acids - metabolism Biological and medical sciences Biological Transport, Active Cell physiology fibroblasts Fibroblasts - cytology Fundamental and applied biological sciences. Psychology Humans Kinetics lysosomes Lysosomes - metabolism man Mathematics Membrane and intracellular transports Molecular and cellular biology Osmolar Concentration Proline - metabolism Serine - metabolism Sodium Chloride - pharmacology Threonine - metabolism
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