Characteristics of Fe(IOO)ATP complex-induced damage to the rat liver mitochondrial membrane

It is well established that several iron complexes can induce oxidative damage in hepatic mitochondrial membranes by catalyzing the formation of .OH radicals and/or by promoting lipid peroxidation. This is a relevant process for the molecular basis of iron overload diseases. The present work demonst...

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Veröffentlicht in:	Molecular and cellular biochemistry 1995-04, Vol.145 (1), p.53-60
Hauptverfasser:	Hermes-Lima, M, Castilho, R.F, Meinicke, A.R, Vercesi, A.E
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Adenosine Triphosphate - pharmacology Animals Butylated Hydroxytoluene - pharmacology Catalase - metabolism Deferoxamine - pharmacology Ferrous Compounds - metabolism Ferrous Compounds - pharmacology ferrous ions free radicals hydroxyl radicals In Vitro Techniques Intracellular Membranes - drug effects iron complexes Lipid Peroxidation liver membrane permeability Membrane Potentials mitochondria Mitochondria, Liver - drug effects Mitochondrial Swelling Models, Chemical Oxidative Stress oxygen Oxygen Consumption Permeability - drug effects Rats Rats, Wistar stress Superoxide Dismutase - metabolism Time Factors
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