A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema
Summary Topical photochemotherapy with psoralen and its derivatives 4.5′,8‐trimethylpsoralen (TMP) and 8‐methoxypsoralen (8‐MOP), with UVA irradiation, was evaluated with regard to minimum phototoxic dose, concentration, timing of UVA irradiation and systemic and local side‐effects, in healthy volun...
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| Veröffentlicht in: | British journal of dermatology (1951) 1995-06, Vol.132 (6), p.964-969 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 132 |
| creator | DE RIE, M.A. VAN EENDENBURG, J.P. VKRSNICK, A.C. STOLK, L.M.L. BOS, J.D. WESTERHOF, W. |
| description | Summary Topical photochemotherapy with psoralen and its derivatives 4.5′,8‐trimethylpsoralen (TMP) and 8‐methoxypsoralen (8‐MOP), with UVA irradiation, was evaluated with regard to minimum phototoxic dose, concentration, timing of UVA irradiation and systemic and local side‐effects, in healthy volunteers. Psoralen (0.005%) in aqueous gel was found to be superior to TMP and 8‐MOP in aqueous gel. No hyperpigmentation was seen after topical PUVA treatment with psoralen in aqueous gel. Patients with plaque‐type psoriasis (n = 7), palmoplantar psoriasis (n = 7) and hyperkeratotic eczema (n = 2) were treated. Topical PUVA therapy was effective in most psoriasis patients, without the occurrence of local or systemic side‐effects. Moreover, hyperkeratotic eczema patients who did not respond to conventional therapy showed partial remission. These results indicate that topical PUVA therapy with psoralen in aqueous gel is a useful therapeutic modality for treatment of psoriasis patients, and patients with recalcitrant dermatoses such as palmoplantar psoriasis and hyperkeratotic eczema. |
| doi_str_mv | 10.1111/j.1365-2133.1995.tb16956.x |
| format | Article |
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Psoralen (0.005%) in aqueous gel was found to be superior to TMP and 8‐MOP in aqueous gel. No hyperpigmentation was seen after topical PUVA treatment with psoralen in aqueous gel. Patients with plaque‐type psoriasis (n = 7), palmoplantar psoriasis (n = 7) and hyperkeratotic eczema (n = 2) were treated. Topical PUVA therapy was effective in most psoriasis patients, without the occurrence of local or systemic side‐effects. Moreover, hyperkeratotic eczema patients who did not respond to conventional therapy showed partial remission. These results indicate that topical PUVA therapy with psoralen in aqueous gel is a useful therapeutic modality for treatment of psoriasis patients, and patients with recalcitrant dermatoses such as palmoplantar psoriasis and hyperkeratotic eczema.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1995.tb16956.x</identifier><identifier>PMID: 7662576</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Diseases of the skin. Cosmetics ; Eczema - drug therapy ; Ficusin - administration & dosage ; Gels ; Humans ; Male ; Medical sciences ; Methoxsalen - administration & dosage ; Psoriasis - drug therapy ; PUVA Therapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Trioxsalen - administration & dosage</subject><ispartof>British journal of dermatology (1951), 1995-06, Vol.132 (6), p.964-969</ispartof><rights>1995 British Association of Dermatologists</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4386-f46724580fc7150d07fe95fffa02fb5c2345cb801cbc0a509946ed96263910c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1995.tb16956.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1995.tb16956.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1416,23928,23929,25138,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3542945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7662576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE RIE, M.A.</creatorcontrib><creatorcontrib>VAN EENDENBURG, J.P.</creatorcontrib><creatorcontrib>VKRSNICK, A.C.</creatorcontrib><creatorcontrib>STOLK, L.M.L.</creatorcontrib><creatorcontrib>BOS, J.D.</creatorcontrib><creatorcontrib>WESTERHOF, W.</creatorcontrib><title>A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary Topical photochemotherapy with psoralen and its derivatives 4.5′,8‐trimethylpsoralen (TMP) and 8‐methoxypsoralen (8‐MOP), with UVA irradiation, was evaluated with regard to minimum phototoxic dose, concentration, timing of UVA irradiation and systemic and local side‐effects, in healthy volunteers. Psoralen (0.005%) in aqueous gel was found to be superior to TMP and 8‐MOP in aqueous gel. No hyperpigmentation was seen after topical PUVA treatment with psoralen in aqueous gel. Patients with plaque‐type psoriasis (n = 7), palmoplantar psoriasis (n = 7) and hyperkeratotic eczema (n = 2) were treated. Topical PUVA therapy was effective in most psoriasis patients, without the occurrence of local or systemic side‐effects. Moreover, hyperkeratotic eczema patients who did not respond to conventional therapy showed partial remission. These results indicate that topical PUVA therapy with psoralen in aqueous gel is a useful therapeutic modality for treatment of psoriasis patients, and patients with recalcitrant dermatoses such as palmoplantar psoriasis and hyperkeratotic eczema.</description><subject>Biological and medical sciences</subject><subject>Diseases of the skin. Cosmetics</subject><subject>Eczema - drug therapy</subject><subject>Ficusin - administration & dosage</subject><subject>Gels</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxsalen - administration & dosage</subject><subject>Psoriasis - drug therapy</subject><subject>PUVA Therapy</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Cosmetics</topic><topic>Eczema - drug therapy</topic><topic>Ficusin - administration & dosage</topic><topic>Gels</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxsalen - administration & dosage</topic><topic>Psoriasis - drug therapy</topic><topic>PUVA Therapy</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Trioxsalen - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE RIE, M.A.</creatorcontrib><creatorcontrib>VAN EENDENBURG, J.P.</creatorcontrib><creatorcontrib>VKRSNICK, A.C.</creatorcontrib><creatorcontrib>STOLK, L.M.L.</creatorcontrib><creatorcontrib>BOS, J.D.</creatorcontrib><creatorcontrib>WESTERHOF, W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE RIE, M.A.</au><au>VAN EENDENBURG, J.P.</au><au>VKRSNICK, A.C.</au><au>STOLK, L.M.L.</au><au>BOS, J.D.</au><au>WESTERHOF, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1995-06</date><risdate>1995</risdate><volume>132</volume><issue>6</issue><spage>964</spage><epage>969</epage><pages>964-969</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary Topical photochemotherapy with psoralen and its derivatives 4.5′,8‐trimethylpsoralen (TMP) and 8‐methoxypsoralen (8‐MOP), with UVA irradiation, was evaluated with regard to minimum phototoxic dose, concentration, timing of UVA irradiation and systemic and local side‐effects, in healthy volunteers. Psoralen (0.005%) in aqueous gel was found to be superior to TMP and 8‐MOP in aqueous gel. No hyperpigmentation was seen after topical PUVA treatment with psoralen in aqueous gel. Patients with plaque‐type psoriasis (n = 7), palmoplantar psoriasis (n = 7) and hyperkeratotic eczema (n = 2) were treated. Topical PUVA therapy was effective in most psoriasis patients, without the occurrence of local or systemic side‐effects. Moreover, hyperkeratotic eczema patients who did not respond to conventional therapy showed partial remission. These results indicate that topical PUVA therapy with psoralen in aqueous gel is a useful therapeutic modality for treatment of psoriasis patients, and patients with recalcitrant dermatoses such as palmoplantar psoriasis and hyperkeratotic eczema.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7662576</pmid><doi>10.1111/j.1365-2133.1995.tb16956.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 1995-06, Vol.132 (6), p.964-969 |
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| subjects | Biological and medical sciences Diseases of the skin. Cosmetics Eczema - drug therapy Ficusin - administration & dosage Gels Humans Male Medical sciences Methoxsalen - administration & dosage Psoriasis - drug therapy PUVA Therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Trioxsalen - administration & dosage |
| title | A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema |
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