Fragile sites, chromosome evolution, and human neoplasia

Fragile sites, chromosome evolution, and human neoplasia

In a study of the possible relationship between human fragile sites, chromosomal rearrangements related to neoplasia, and chromosome regions involved in evolutionary changes, we have found that 17 fragile sites related to cancer, 15 fragile sites not related to cancer, and 17 non-fragile regions als...

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Veröffentlicht in:Human genetics 1987-04, Vol.75 (4), p.345-349
Hauptverfasser: MIRO, R, CONCEPCION CLEMENTE, I, FUSTER, C, EGOZCUE, J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Biological Evolution
Chromosome Aberrations
Chromosome Fragile Sites
Chromosome Fragility
General aspects
Humans
Medical sciences
Neoplasms - genetics
Primates - genetics
Tumors
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Zusammenfassung:In a study of the possible relationship between human fragile sites, chromosomal rearrangements related to neoplasia, and chromosome regions involved in evolutionary changes, we have found that 17 fragile sites related to cancer, 15 fragile sites not related to cancer, and 17 non-fragile regions also related to human malignancy correspond or are close to bands involved in rearrangements that have taken place during chromosomal evolution in primates.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00284105