Variables Influencing the Thrombostat 4000: Recommended Standardization
Abstract The in vitro bleeding test (IVBT) (Thrombostat 4000) was performed on blood samples from healthy blood donors using a “preliminary standard test.” Only one factor of the test procedure was changed each time. We found the following parameters to have a significant influence on the test resul...
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| Veröffentlicht in: | Seminars in thrombosis and hemostasis 1995-01, Vol.21 (S 02), p.11-19 |
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| container_issue | S 02 |
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| container_title | Seminars in thrombosis and hemostasis |
| container_volume | 21 |
| creator | Dietrich, Gerald V Kretschmer, Volker Weber, Dagmar Haupt, Winfried Langen, Betiina Huss, Bernd |
| description | Abstract
The in vitro bleeding test (IVBT) (Thrombostat 4000) was performed on blood samples from healthy blood donors using a “preliminary standard test.” Only one factor of the test procedure was changed each time.
We found the following parameters to have a significant influence on the test results: time interval between sampling and testing, diameter of the filter's aperture, capillary diameter, aggregating agents and their concentration, temperature of the blood and cartridges, method of drying the capillaries, the aspiration pressure, and the hematocrit of the blood sample. According to our data, we propose a standard IVBT for routine application and modifications for special diagnostic use. |
| doi_str_mv | 10.1055/s-0032-1313597 |
| format | Article |
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The in vitro bleeding test (IVBT) (Thrombostat 4000) was performed on blood samples from healthy blood donors using a “preliminary standard test.” Only one factor of the test procedure was changed each time.
We found the following parameters to have a significant influence on the test results: time interval between sampling and testing, diameter of the filter's aperture, capillary diameter, aggregating agents and their concentration, temperature of the blood and cartridges, method of drying the capillaries, the aspiration pressure, and the hematocrit of the blood sample. According to our data, we propose a standard IVBT for routine application and modifications for special diagnostic use.</description><identifier>ISSN: 0094-6176</identifier><identifier>EISSN: 1098-9064</identifier><identifier>DOI: 10.1055/s-0032-1313597</identifier><identifier>PMID: 7660151</identifier><language>eng</language><publisher>333 Seventh Avenue, New York, NY 10001, USA: Thieme Medical Publishers</publisher><subject>Adenosine Diphosphate - pharmacology ; Bleeding Time ; Blood Coagulation Tests - instrumentation ; Blood Coagulation Tests - standards ; Humans ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Prothrombin Time</subject><ispartof>Seminars in thrombosis and hemostasis, 1995-01, Vol.21 (S 02), p.11-19</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-91c9bf7cc46fc4a9030fc30de137a41de65216f2f06608ca9ace11dc7328c8b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0032-1313597.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7660151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dietrich, Gerald V</creatorcontrib><creatorcontrib>Kretschmer, Volker</creatorcontrib><creatorcontrib>Weber, Dagmar</creatorcontrib><creatorcontrib>Haupt, Winfried</creatorcontrib><creatorcontrib>Langen, Betiina</creatorcontrib><creatorcontrib>Huss, Bernd</creatorcontrib><title>Variables Influencing the Thrombostat 4000: Recommended Standardization</title><title>Seminars in thrombosis and hemostasis</title><addtitle>Semin Thromb Hemost</addtitle><description>Abstract
The in vitro bleeding test (IVBT) (Thrombostat 4000) was performed on blood samples from healthy blood donors using a “preliminary standard test.” Only one factor of the test procedure was changed each time.
We found the following parameters to have a significant influence on the test results: time interval between sampling and testing, diameter of the filter's aperture, capillary diameter, aggregating agents and their concentration, temperature of the blood and cartridges, method of drying the capillaries, the aspiration pressure, and the hematocrit of the blood sample. According to our data, we propose a standard IVBT for routine application and modifications for special diagnostic use.</description><subject>Adenosine Diphosphate - pharmacology</subject><subject>Bleeding Time</subject><subject>Blood Coagulation Tests - instrumentation</subject><subject>Blood Coagulation Tests - standards</subject><subject>Humans</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Prothrombin Time</subject><issn>0094-6176</issn><issn>1098-9064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EKqWwsiFlYku5S5wPs6EKSqVKSFBYLce50FRJXGxngF9PqkZsTDe8H3rvYewaYY6QJHcuBIijEGOME5GdsCmCyEMBKT9lUwDBwxSz9JxdOLcDQJ5DNGGTLE0BE5yy5YeytSoacsGqq5qeOl13n4HfUrDZWtMWxnnlAw4A98EradO21JVUBm9edaWyZf2jfG26S3ZWqcbR1Xhn7P3pcbN4Dtcvy9XiYR3qOMp9KFCLosq05mmluRIQQ6VjKAnjTHEsKU0iTKuogmFgrpVQmhBLnQ1pnRdJPGO3x969NV89OS_b2mlqGtWR6Z3MMp5HucDBOD8atTXOWark3tatst8SQR7ISScP5ORIbgjcjM190VL5Zx9RDXp41P22ppbkzvS2G179r-8X2E52gQ</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>Dietrich, Gerald V</creator><creator>Kretschmer, Volker</creator><creator>Weber, Dagmar</creator><creator>Haupt, Winfried</creator><creator>Langen, Betiina</creator><creator>Huss, Bernd</creator><general>Thieme Medical Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950101</creationdate><title>Variables Influencing the Thrombostat 4000: Recommended Standardization</title><author>Dietrich, Gerald V ; Kretschmer, Volker ; Weber, Dagmar ; Haupt, Winfried ; Langen, Betiina ; Huss, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-91c9bf7cc46fc4a9030fc30de137a41de65216f2f06608ca9ace11dc7328c8b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenosine Diphosphate - pharmacology</topic><topic>Bleeding Time</topic><topic>Blood Coagulation Tests - instrumentation</topic><topic>Blood Coagulation Tests - standards</topic><topic>Humans</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Prothrombin Time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dietrich, Gerald V</creatorcontrib><creatorcontrib>Kretschmer, Volker</creatorcontrib><creatorcontrib>Weber, Dagmar</creatorcontrib><creatorcontrib>Haupt, Winfried</creatorcontrib><creatorcontrib>Langen, Betiina</creatorcontrib><creatorcontrib>Huss, Bernd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in thrombosis and hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dietrich, Gerald V</au><au>Kretschmer, Volker</au><au>Weber, Dagmar</au><au>Haupt, Winfried</au><au>Langen, Betiina</au><au>Huss, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variables Influencing the Thrombostat 4000: Recommended Standardization</atitle><jtitle>Seminars in thrombosis and hemostasis</jtitle><addtitle>Semin Thromb Hemost</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>21</volume><issue>S 02</issue><spage>11</spage><epage>19</epage><pages>11-19</pages><issn>0094-6176</issn><eissn>1098-9064</eissn><abstract>Abstract
The in vitro bleeding test (IVBT) (Thrombostat 4000) was performed on blood samples from healthy blood donors using a “preliminary standard test.” Only one factor of the test procedure was changed each time.
We found the following parameters to have a significant influence on the test results: time interval between sampling and testing, diameter of the filter's aperture, capillary diameter, aggregating agents and their concentration, temperature of the blood and cartridges, method of drying the capillaries, the aspiration pressure, and the hematocrit of the blood sample. According to our data, we propose a standard IVBT for routine application and modifications for special diagnostic use.</abstract><cop>333 Seventh Avenue, New York, NY 10001, USA</cop><pub>Thieme Medical Publishers</pub><pmid>7660151</pmid><doi>10.1055/s-0032-1313597</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0094-6176 |
| ispartof | Seminars in thrombosis and hemostasis, 1995-01, Vol.21 (S 02), p.11-19 |
| issn | 0094-6176 1098-9064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77482891 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Adenosine Diphosphate - pharmacology Bleeding Time Blood Coagulation Tests - instrumentation Blood Coagulation Tests - standards Humans Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Prothrombin Time |
| title | Variables Influencing the Thrombostat 4000: Recommended Standardization |
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