Methamphetamine-induced dopaminergic hyperactivity is not accompanied with increase in tyrosine hydroxylase mRNA of the rat midbrain

Tyrosine hydroxylase (TH) mRNA was measured in the midbrain of rats treated repeatedly with methamphetamine (MAP). Male Sprague-Dawley rats were daily injected with MAP (5 mg/kg, i.p., once daily) or saline for 14 days. Progressive augmentation was observed in MAP-induced stereotyped behaviors. Afte...

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Veröffentlicht in:Neuroscience letters 1995-05, Vol.191 (1), p.107-110
Hauptverfasser: Ishimaru, Masahiko, Hashimoto, Takanori, Obata, Kunihiko, Fukamauchi, Fumihiko
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Sprache:eng
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