Effect of aminophylline on high-energy phosphate metabolism and fatigue in the diaphragm

Diaphragmatic fatigue causes respiratory failure, for which aminophylline has been used as therapy. Because the mechanism of action of aminophylline in reversing diaphragmatic fatigue is unclear, we used in vivo 31P magnetic resonance spectroscopy (MRS) to determine the relation between diaphragmati...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1995-09, Vol.83 (3), p.557-567
Hauptverfasser:	IDE, T, NICHOLS, D. G, BUCK, J. R, ELEFF, S. M, SHUNGU, D. C, ROBOTHAM, J. L, FITZGERALD, R. S, TRAYSTMAN, R. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Aminophylline - blood Aminophylline - pharmacology Animals Biological and medical sciences Calcium - metabolism Diaphragm - drug effects Diaphragm - metabolism Medical sciences Muscle Fatigue - drug effects Pharmacology. Drug treatments Phosphates - metabolism Phosphocreatine - metabolism Respiratory system Swine
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