Microheterogeneity forms of alpha 1-acid glycoprotein as indicators of rheumatoid arthritis activity
The microheterogeneity of alpha 1-acid glycoprotein (AGP) has been studied in the sera of 48 patients with rheumatoid arthritis and of 12 healthy individuals. For each rheumatoid patient the disease activity has been assessed and each patient has been assigned to one of four activity grades: I, inac...
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| Veröffentlicht in: | Clinica chimica acta 1987-03, Vol.163 (2), p.185-190 |
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| container_title | Clinica chimica acta |
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| creator | Mackiewicz, Andrzej Pawo̵wski, Tomasz Mackiewicz-Pawłowska, Anna Wiktorowicz, Krzysztof Mackiewicz, Stefan |
| description | The microheterogeneity of alpha
1-acid glycoprotein (AGP) has been studied in the sera of 48 patients with rheumatoid arthritis and of 12 healthy individuals. For each rheumatoid patient the disease activity has been assessed and each patient has been assigned to one of four activity grades: I, inactive; II, mildly active; HI, moderately active; and IV, severe. Concanavalin A-affinity electrophoresis revealed three microheterogeneity variants of AGP: non-reactive with Con A, weakly reactive with Con A and strongly reactive with Con A. The relative amounts of AGP-variants observed in the healthy donors were similar to those observed in the patients with activity grade I, but differed significantly from patients with grades II, III and IV. The differences between the AGP-patterns of patients with activity grades II, III and IV were also statistically significant. |
| doi_str_mv | 10.1016/0009-8981(87)90021-0 |
| format | Article |
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1-acid glycoprotein (AGP) has been studied in the sera of 48 patients with rheumatoid arthritis and of 12 healthy individuals. For each rheumatoid patient the disease activity has been assessed and each patient has been assigned to one of four activity grades: I, inactive; II, mildly active; HI, moderately active; and IV, severe. Concanavalin A-affinity electrophoresis revealed three microheterogeneity variants of AGP: non-reactive with Con A, weakly reactive with Con A and strongly reactive with Con A. The relative amounts of AGP-variants observed in the healthy donors were similar to those observed in the patients with activity grade I, but differed significantly from patients with grades II, III and IV. The differences between the AGP-patterns of patients with activity grades II, III and IV were also statistically significant.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(87)90021-0</identifier><identifier>PMID: 3568422</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Affinity-electrophoresis ; alpha 1-Acid glycoprotein ; Arthritis, Rheumatoid - blood ; C-reactive protein ; C-Reactive Protein - analysis ; Concanavalin A ; Electrophoresis - methods ; Humans ; Immunoassay - methods ; Microheterogeneity ; Orosomucoid - classification ; Rheumatoid arthritis</subject><ispartof>Clinica chimica acta, 1987-03, Vol.163 (2), p.185-190</ispartof><rights>1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(87)90021-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3568422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackiewicz, Andrzej</creatorcontrib><creatorcontrib>Pawo̵wski, Tomasz</creatorcontrib><creatorcontrib>Mackiewicz-Pawłowska, Anna</creatorcontrib><creatorcontrib>Wiktorowicz, Krzysztof</creatorcontrib><creatorcontrib>Mackiewicz, Stefan</creatorcontrib><title>Microheterogeneity forms of alpha 1-acid glycoprotein as indicators of rheumatoid arthritis activity</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>The microheterogeneity of alpha
1-acid glycoprotein (AGP) has been studied in the sera of 48 patients with rheumatoid arthritis and of 12 healthy individuals. For each rheumatoid patient the disease activity has been assessed and each patient has been assigned to one of four activity grades: I, inactive; II, mildly active; HI, moderately active; and IV, severe. Concanavalin A-affinity electrophoresis revealed three microheterogeneity variants of AGP: non-reactive with Con A, weakly reactive with Con A and strongly reactive with Con A. The relative amounts of AGP-variants observed in the healthy donors were similar to those observed in the patients with activity grade I, but differed significantly from patients with grades II, III and IV. The differences between the AGP-patterns of patients with activity grades II, III and IV were also statistically significant.</description><subject>Affinity-electrophoresis</subject><subject>alpha 1-Acid glycoprotein</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Concanavalin A</subject><subject>Electrophoresis - methods</subject><subject>Humans</subject><subject>Immunoassay - methods</subject><subject>Microheterogeneity</subject><subject>Orosomucoid - classification</subject><subject>Rheumatoid arthritis</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kV1LwzAYhYMoc07_gUKvRC-q-WqT3ggy_IKJN3odsuTtGmmbmaSD_Xs7N7x6ObwPh8M5CF0SfEcwKe8xxlUuK0lupLitMKYkx0doSqRgOeMVPUbTf-QUncX4PUqOSzJBE1aUklM6RfbdmeAbSBD8CnpwaZvVPnQx83Wm23WjM5Jr42y2arfGr4NP4PpMx8z11hmdfPhDQwNDN6oR1CE1wSUXM22S24yO5-ik1m2Ei8Odoa_np8_5a774eHmbPy5yIFjSvCwtLQpKZK2NMKywlnFtecUZKchSaiEwZUsJtbY11wURIETNOGFCC8sEZjN0vfcdY_4MEJPqXDTQtroHP0QlBBeFKIsRvDqAw7IDq9bBdTps1aGW8f-w_8OYduMgqGgc9AasC2CSst4pgtVuBrXrWO06VlKovxkUZr9ecHnv</recordid><startdate>19870316</startdate><enddate>19870316</enddate><creator>Mackiewicz, Andrzej</creator><creator>Pawo̵wski, Tomasz</creator><creator>Mackiewicz-Pawłowska, Anna</creator><creator>Wiktorowicz, Krzysztof</creator><creator>Mackiewicz, Stefan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19870316</creationdate><title>Microheterogeneity forms of alpha 1-acid glycoprotein as indicators of rheumatoid arthritis activity</title><author>Mackiewicz, Andrzej ; Pawo̵wski, Tomasz ; Mackiewicz-Pawłowska, Anna ; Wiktorowicz, Krzysztof ; Mackiewicz, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1082-66d255218fac7c35dd34ad4943151b8a77023b8efadf4a517e77f34137a7d3703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Affinity-electrophoresis</topic><topic>alpha 1-Acid glycoprotein</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Concanavalin A</topic><topic>Electrophoresis - methods</topic><topic>Humans</topic><topic>Immunoassay - methods</topic><topic>Microheterogeneity</topic><topic>Orosomucoid - classification</topic><topic>Rheumatoid arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackiewicz, Andrzej</creatorcontrib><creatorcontrib>Pawo̵wski, Tomasz</creatorcontrib><creatorcontrib>Mackiewicz-Pawłowska, Anna</creatorcontrib><creatorcontrib>Wiktorowicz, Krzysztof</creatorcontrib><creatorcontrib>Mackiewicz, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackiewicz, Andrzej</au><au>Pawo̵wski, Tomasz</au><au>Mackiewicz-Pawłowska, Anna</au><au>Wiktorowicz, Krzysztof</au><au>Mackiewicz, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microheterogeneity forms of alpha 1-acid glycoprotein as indicators of rheumatoid arthritis activity</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1987-03-16</date><risdate>1987</risdate><volume>163</volume><issue>2</issue><spage>185</spage><epage>190</epage><pages>185-190</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>The microheterogeneity of alpha
1-acid glycoprotein (AGP) has been studied in the sera of 48 patients with rheumatoid arthritis and of 12 healthy individuals. For each rheumatoid patient the disease activity has been assessed and each patient has been assigned to one of four activity grades: I, inactive; II, mildly active; HI, moderately active; and IV, severe. Concanavalin A-affinity electrophoresis revealed three microheterogeneity variants of AGP: non-reactive with Con A, weakly reactive with Con A and strongly reactive with Con A. The relative amounts of AGP-variants observed in the healthy donors were similar to those observed in the patients with activity grade I, but differed significantly from patients with grades II, III and IV. The differences between the AGP-patterns of patients with activity grades II, III and IV were also statistically significant.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3568422</pmid><doi>10.1016/0009-8981(87)90021-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1987-03, Vol.163 (2), p.185-190 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77475765 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Affinity-electrophoresis alpha 1-Acid glycoprotein Arthritis, Rheumatoid - blood C-reactive protein C-Reactive Protein - analysis Concanavalin A Electrophoresis - methods Humans Immunoassay - methods Microheterogeneity Orosomucoid - classification Rheumatoid arthritis |
| title | Microheterogeneity forms of alpha 1-acid glycoprotein as indicators of rheumatoid arthritis activity |
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