Regulation of the antibody response by the acute phase reactant: Mouse serum amyloid P-component (SAP)
Serum amyloid P-component (SAP) is the major acute phase reactant (APR) of mice. Purified mouse SAP at 0.1 to 10.0 μg/ml selectively suppressed the secondary in vitro IgG antibody plaque-forming cell (PFC) response to the T-dependent antigen TNP-KLH but not to the T-independent antigens TNP-LPS and...
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| Veröffentlicht in: | Cellular immunology 1987-05, Vol.106 (2), p.273-286 |
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| creator | Sarlo, Katherine T. Mortensen, Richard F. |
| description | Serum amyloid P-component (SAP) is the major acute phase reactant (APR) of mice. Purified mouse SAP at 0.1 to 10.0 μg/ml selectively suppressed the secondary
in vitro IgG antibody plaque-forming cell (PFC) response to the T-dependent antigen TNP-KLH but not to the T-independent antigens TNP-LPS and DNP-Lys-Ficoll. The suppression was antigen nonspecific. The mechanism of suppression occurred primarily through the activation of Lyt-1
+, I-J
+ suppressor-inducer cells, which in turn activated a Lyt-2
+ suppressor T-cell population. The activity of preexisting, antigen-specific Lyt-2
+ suppressor T cells was not influenced by SAP. The antigen-nonspecific suppressor T cells generated by SAP were sensitive to cyclophosphamide. Removal of SAP from the culture fluid with rabbit anti-Mo SAP antibody or agarose beads abrogated the suppression. Pentraxin proteins closely related to mouse SAP, such as human SAP and hamster female protein (FP), also displayed immunoregulatory activity of the antibody response by the same cellular mechanism. The results suggest that SAP regulates antibody responses by the activation of suppressor-inducer T cells and that the regulation of the antibody response during the acute stage of inflammation may occur via SAP. |
| doi_str_mv | 10.1016/0008-8749(87)90171-7 |
| format | Article |
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in vitro IgG antibody plaque-forming cell (PFC) response to the T-dependent antigen TNP-KLH but not to the T-independent antigens TNP-LPS and DNP-Lys-Ficoll. The suppression was antigen nonspecific. The mechanism of suppression occurred primarily through the activation of Lyt-1
+, I-J
+ suppressor-inducer cells, which in turn activated a Lyt-2
+ suppressor T-cell population. The activity of preexisting, antigen-specific Lyt-2
+ suppressor T cells was not influenced by SAP. The antigen-nonspecific suppressor T cells generated by SAP were sensitive to cyclophosphamide. Removal of SAP from the culture fluid with rabbit anti-Mo SAP antibody or agarose beads abrogated the suppression. Pentraxin proteins closely related to mouse SAP, such as human SAP and hamster female protein (FP), also displayed immunoregulatory activity of the antibody response by the same cellular mechanism. The results suggest that SAP regulates antibody responses by the activation of suppressor-inducer T cells and that the regulation of the antibody response during the acute stage of inflammation may occur via SAP.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(87)90171-7</identifier><identifier>PMID: 2436816</identifier><identifier>CODEN: CLIMB8</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Alpha-Globulins - pharmacology ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antibody Formation ; Antigens, Ly - analysis ; Antigens, T-Independent - immunology ; Biological and medical sciences ; C-Reactive Protein ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immune Tolerance ; Immunobiology ; Immunologic Memory ; Mice ; Miscellaneous ; Regulatory factors and their cellular receptors ; Serum Amyloid P-Component - physiology ; Spleen - immunology ; T-Lymphocytes, Regulatory - classification ; T-Lymphocytes, Regulatory - immunology ; Thioglycolates - immunology ; Trinitrobenzenes - immunology</subject><ispartof>Cellular immunology, 1987-05, Vol.106 (2), p.273-286</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-507833b5b790a68c56ba7d35459423e5bd3a9b3ca9535e623c019971b94093cc3</citedby><cites>FETCH-LOGICAL-c417t-507833b5b790a68c56ba7d35459423e5bd3a9b3ca9535e623c019971b94093cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0008-8749(87)90171-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7464350$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2436816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarlo, Katherine T.</creatorcontrib><creatorcontrib>Mortensen, Richard F.</creatorcontrib><title>Regulation of the antibody response by the acute phase reactant: Mouse serum amyloid P-component (SAP)</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>Serum amyloid P-component (SAP) is the major acute phase reactant (APR) of mice. Purified mouse SAP at 0.1 to 10.0 μg/ml selectively suppressed the secondary
in vitro IgG antibody plaque-forming cell (PFC) response to the T-dependent antigen TNP-KLH but not to the T-independent antigens TNP-LPS and DNP-Lys-Ficoll. The suppression was antigen nonspecific. The mechanism of suppression occurred primarily through the activation of Lyt-1
+, I-J
+ suppressor-inducer cells, which in turn activated a Lyt-2
+ suppressor T-cell population. The activity of preexisting, antigen-specific Lyt-2
+ suppressor T cells was not influenced by SAP. The antigen-nonspecific suppressor T cells generated by SAP were sensitive to cyclophosphamide. Removal of SAP from the culture fluid with rabbit anti-Mo SAP antibody or agarose beads abrogated the suppression. Pentraxin proteins closely related to mouse SAP, such as human SAP and hamster female protein (FP), also displayed immunoregulatory activity of the antibody response by the same cellular mechanism. The results suggest that SAP regulates antibody responses by the activation of suppressor-inducer T cells and that the regulation of the antibody response during the acute stage of inflammation may occur via SAP.</description><subject>Alpha-Globulins - pharmacology</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>Antigens, Ly - analysis</subject><subject>Antigens, T-Independent - immunology</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immune Tolerance</subject><subject>Immunobiology</subject><subject>Immunologic Memory</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Serum Amyloid P-Component - physiology</subject><subject>Spleen - immunology</subject><subject>T-Lymphocytes, Regulatory - classification</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Thioglycolates - immunology</subject><subject>Trinitrobenzenes - immunology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctqHDEQRUWIsSdO_iABLUywF-1Io1cri4Ax8QNsYvJYC0ldbct0tyaSOjB_H01mmKWzUaG65xbFLYTeU3JOCZWfCCFt0yquT1t1pglVtFGv0IISTZollew1WuyRI_Qm52dCKOWaHKLDJWeypXKB-u_wOA-2hDjh2OPyBNhOJbjYrXGCvIpTBuzWW8HPBfDqydZWAutLJT_j-zjXf4Y0j9iO6yGGDj80Po7VC1PBpz8uHs7eooPeDhne7eox-nX19eflTXP37fr28uKu8Zyq0giiWsaccEoTK1svpLOqY4ILzZcMhOuY1Y55qwUTIJfME6q1ok5zopn37Bh93M5dpfh7hlzMGLKHYbAT1D2NUlwJyfl_QcpbzipdQb4FfYo5J-jNKoXRprWhxGzuYDYhm03I9TH_7mBUtX3YzZ_dCN3etAu-6ic73WZvhz7ZyYe8xxSXnAlSsS9bDGpofwIkk32AyUMXEvhiuhhe3uMvjWqiaQ</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Sarlo, Katherine T.</creator><creator>Mortensen, Richard F.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19870501</creationdate><title>Regulation of the antibody response by the acute phase reactant: Mouse serum amyloid P-component (SAP)</title><author>Sarlo, Katherine T. ; Mortensen, Richard F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-507833b5b790a68c56ba7d35459423e5bd3a9b3ca9535e623c019971b94093cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Alpha-Globulins - pharmacology</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antigens, Ly - analysis</topic><topic>Antigens, T-Independent - immunology</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immune Tolerance</topic><topic>Immunobiology</topic><topic>Immunologic Memory</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Serum Amyloid P-Component - physiology</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes, Regulatory - classification</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Thioglycolates - immunology</topic><topic>Trinitrobenzenes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarlo, Katherine T.</creatorcontrib><creatorcontrib>Mortensen, Richard F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarlo, Katherine T.</au><au>Mortensen, Richard F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of the antibody response by the acute phase reactant: Mouse serum amyloid P-component (SAP)</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>106</volume><issue>2</issue><spage>273</spage><epage>286</epage><pages>273-286</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><coden>CLIMB8</coden><abstract>Serum amyloid P-component (SAP) is the major acute phase reactant (APR) of mice. Purified mouse SAP at 0.1 to 10.0 μg/ml selectively suppressed the secondary
in vitro IgG antibody plaque-forming cell (PFC) response to the T-dependent antigen TNP-KLH but not to the T-independent antigens TNP-LPS and DNP-Lys-Ficoll. The suppression was antigen nonspecific. The mechanism of suppression occurred primarily through the activation of Lyt-1
+, I-J
+ suppressor-inducer cells, which in turn activated a Lyt-2
+ suppressor T-cell population. The activity of preexisting, antigen-specific Lyt-2
+ suppressor T cells was not influenced by SAP. The antigen-nonspecific suppressor T cells generated by SAP were sensitive to cyclophosphamide. Removal of SAP from the culture fluid with rabbit anti-Mo SAP antibody or agarose beads abrogated the suppression. Pentraxin proteins closely related to mouse SAP, such as human SAP and hamster female protein (FP), also displayed immunoregulatory activity of the antibody response by the same cellular mechanism. The results suggest that SAP regulates antibody responses by the activation of suppressor-inducer T cells and that the regulation of the antibody response during the acute stage of inflammation may occur via SAP.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2436816</pmid><doi>10.1016/0008-8749(87)90171-7</doi><tpages>14</tpages></addata></record> |
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| ispartof | Cellular immunology, 1987-05, Vol.106 (2), p.273-286 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alpha-Globulins - pharmacology Analysis of the immune response. Humoral and cellular immunity Animals Antibody Formation Antigens, Ly - analysis Antigens, T-Independent - immunology Biological and medical sciences C-Reactive Protein Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immune Tolerance Immunobiology Immunologic Memory Mice Miscellaneous Regulatory factors and their cellular receptors Serum Amyloid P-Component - physiology Spleen - immunology T-Lymphocytes, Regulatory - classification T-Lymphocytes, Regulatory - immunology Thioglycolates - immunology Trinitrobenzenes - immunology |
| title | Regulation of the antibody response by the acute phase reactant: Mouse serum amyloid P-component (SAP) |
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