MNSs Genetic Polymorphism and Intrauterine Selection Through Habitual Abortion
Distribution of MNSs genotypes and possible relation with gestational duration of aborted fetuses were studied in 88 couples with habitual abortion. An excess of couples S females X s males with respect to expected values assuming random mating was observed. The duration of gestation of aborted fetu...
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| Veröffentlicht in: | Human biology 1987-02, Vol.59 (1), p.103-120 |
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| creator | BOTTINI, E. BONCI, E. GLORIA-BOTTINI, F. NICOTRA, M. CARAPELLA, E. COGHI, I. LUCARINI, N. MARTINI, P. A. PARIS, D. BONCI, M. FINOCCHI, G. |
| description | Distribution of MNSs genotypes and possible relation with gestational duration of aborted fetuses were studied in 88 couples with habitual abortion. An excess of couples S females X s males with respect to expected values assuming random mating was observed. The duration of gestation of aborted fetuses showed a negative linear relation with maternal doses of s and a positive linear relation with paternal dose of s. Mean gestational duration revealed a significant heterogeneity in relation to MN and Ss types of mating. A striking increase of mean gestational duration of aborted fetuses was observed in couples mother S x father s. Sialoglycoproteins similar to glycophorins controlled by MNSs system may be present at trophoblastic level and their genetic variability may contribute to modulation of maternal fetal immunological relationship. On the basis of recent studies suggesting that MNSs system may be an important determinant of graft-versus host disease and that HLA restricted proliferative responses occurs in vitro in association with M and N antigens, the possibility of maternal-fetal incompatibility in this system should be also considered. |
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A. ; PARIS, D. ; BONCI, M. ; FINOCCHI, G.</creator><creatorcontrib>BOTTINI, E. ; BONCI, E. ; GLORIA-BOTTINI, F. ; NICOTRA, M. ; CARAPELLA, E. ; COGHI, I. ; LUCARINI, N. ; MARTINI, P. A. ; PARIS, D. ; BONCI, M. ; FINOCCHI, G.</creatorcontrib><description>Distribution of MNSs genotypes and possible relation with gestational duration of aborted fetuses were studied in 88 couples with habitual abortion. An excess of couples S females X s males with respect to expected values assuming random mating was observed. The duration of gestation of aborted fetuses showed a negative linear relation with maternal doses of s and a positive linear relation with paternal dose of s. Mean gestational duration revealed a significant heterogeneity in relation to MN and Ss types of mating. A striking increase of mean gestational duration of aborted fetuses was observed in couples mother S x father s. Sialoglycoproteins similar to glycophorins controlled by MNSs system may be present at trophoblastic level and their genetic variability may contribute to modulation of maternal fetal immunological relationship. On the basis of recent studies suggesting that MNSs system may be an important determinant of graft-versus host disease and that HLA restricted proliferative responses occurs in vitro in association with M and N antigens, the possibility of maternal-fetal incompatibility in this system should be also considered.</description><identifier>ISSN: 0018-7143</identifier><identifier>EISSN: 1534-6617</identifier><identifier>PMID: 3570249</identifier><identifier>CODEN: HUBIAA</identifier><language>eng</language><publisher>Detroit, MI: Wayne State University Press</publisher><subject>Abortion ; Abortion, Habitual - genetics ; Biological and medical sciences ; Blood grouping ; Blood groups ; Diseases of mother, fetus and pregnancy ; Female ; Fetal Death - genetics ; Fetus ; Genetic polymorphism ; Genotypes ; Gestation period ; Gynecology. Andrology. Obstetrics ; Habitual abortion ; Humans ; Mating behavior ; Medical genetics ; Medical sciences ; MNSs Blood-Group System ; Polymorphism, Genetic ; Pregnancy ; Pregnancy. Fetus. 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A.</creatorcontrib><creatorcontrib>PARIS, D.</creatorcontrib><creatorcontrib>BONCI, M.</creatorcontrib><creatorcontrib>FINOCCHI, G.</creatorcontrib><title>MNSs Genetic Polymorphism and Intrauterine Selection Through Habitual Abortion</title><title>Human biology</title><addtitle>Hum Biol</addtitle><description>Distribution of MNSs genotypes and possible relation with gestational duration of aborted fetuses were studied in 88 couples with habitual abortion. An excess of couples S females X s males with respect to expected values assuming random mating was observed. The duration of gestation of aborted fetuses showed a negative linear relation with maternal doses of s and a positive linear relation with paternal dose of s. Mean gestational duration revealed a significant heterogeneity in relation to MN and Ss types of mating. A striking increase of mean gestational duration of aborted fetuses was observed in couples mother S x father s. Sialoglycoproteins similar to glycophorins controlled by MNSs system may be present at trophoblastic level and their genetic variability may contribute to modulation of maternal fetal immunological relationship. On the basis of recent studies suggesting that MNSs system may be an important determinant of graft-versus host disease and that HLA restricted proliferative responses occurs in vitro in association with M and N antigens, the possibility of maternal-fetal incompatibility in this system should be also considered.</description><subject>Abortion</subject><subject>Abortion, Habitual - genetics</subject><subject>Biological and medical sciences</subject><subject>Blood grouping</subject><subject>Blood groups</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Death - genetics</subject><subject>Fetus</subject><subject>Genetic polymorphism</subject><subject>Genotypes</subject><subject>Gestation period</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Habitual abortion</subject><subject>Humans</subject><subject>Mating behavior</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>MNSs Blood-Group System</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. 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A.</au><au>PARIS, D.</au><au>BONCI, M.</au><au>FINOCCHI, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MNSs Genetic Polymorphism and Intrauterine Selection Through Habitual Abortion</atitle><jtitle>Human biology</jtitle><addtitle>Hum Biol</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>59</volume><issue>1</issue><spage>103</spage><epage>120</epage><pages>103-120</pages><issn>0018-7143</issn><eissn>1534-6617</eissn><coden>HUBIAA</coden><abstract>Distribution of MNSs genotypes and possible relation with gestational duration of aborted fetuses were studied in 88 couples with habitual abortion. An excess of couples S females X s males with respect to expected values assuming random mating was observed. The duration of gestation of aborted fetuses showed a negative linear relation with maternal doses of s and a positive linear relation with paternal dose of s. Mean gestational duration revealed a significant heterogeneity in relation to MN and Ss types of mating. A striking increase of mean gestational duration of aborted fetuses was observed in couples mother S x father s. Sialoglycoproteins similar to glycophorins controlled by MNSs system may be present at trophoblastic level and their genetic variability may contribute to modulation of maternal fetal immunological relationship. On the basis of recent studies suggesting that MNSs system may be an important determinant of graft-versus host disease and that HLA restricted proliferative responses occurs in vitro in association with M and N antigens, the possibility of maternal-fetal incompatibility in this system should be also considered.</abstract><cop>Detroit, MI</cop><pub>Wayne State University Press</pub><pmid>3570249</pmid><tpages>18</tpages></addata></record> |
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| ispartof | Human biology, 1987-02, Vol.59 (1), p.103-120 |
| issn | 0018-7143 1534-6617 |
| language | eng |
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| source | MEDLINE; Periodicals Index Online; Jstor Complete Legacy; Alma/SFX Local Collection |
| subjects | Abortion Abortion, Habitual - genetics Biological and medical sciences Blood grouping Blood groups Diseases of mother, fetus and pregnancy Female Fetal Death - genetics Fetus Genetic polymorphism Genotypes Gestation period Gynecology. Andrology. Obstetrics Habitual abortion Humans Mating behavior Medical genetics Medical sciences MNSs Blood-Group System Polymorphism, Genetic Pregnancy Pregnancy. Fetus. Placenta Selection, Genetic |
| title | MNSs Genetic Polymorphism and Intrauterine Selection Through Habitual Abortion |
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