Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates
Increased circulating nucleated erythrocytes (NRBCs) in the newborn period can be markers of chronic fetal hypoxia, which in turn may be a risk factor for intracranial hemorrhage (IVH). To evaluate the relation between chronic intrauterine hypoxia and IVH, we compared the courses of the absolute NRB...
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| Veröffentlicht in: | Pediatrics (Evanston) 1995-09, Vol.96 (3), p.475-478 |
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| creator | GREEN, D. W HENDON, B MIMOUNI, F. B |
| description | Increased circulating nucleated erythrocytes (NRBCs) in the newborn period can be markers of chronic fetal hypoxia, which in turn may be a risk factor for intracranial hemorrhage (IVH). To evaluate the relation between chronic intrauterine hypoxia and IVH, we compared the courses of the absolute NRBC (ANRBC) count in preterm newborns with and without intracranial hemorrhage.
We measured ANRBC counts in the first 6 days of life in appropriate for gestational age newborns at 32 weeks' gestation or earlier with (n = 46) and without (n = 103) IVH, who were not at risk for altered erythropoiesis.
The ANRBC counts at birth were higher in infants who developed severe IVH than in control infants without IVH (P < .03). The ANRBC counts peaked on day 2 or 3 in newborns with IVH, but declined continuously from a peak on day 1 in the control group. Stepwise regression analysis of multiple variables revealed that the grade of IVH had the greatest impact on ANRBC counts. An ANRBC count of at least 2.0 x 10(9)/L on day 1 of life had a sensitivity of 63% and a specificity of 79% in predicting grade III or IV IVH:
An elevated or increasing ANRBC count in a preterm newborn is a potential marker for an impending or present severe IVH, respectively, and may reflect a state of altered prenatal or postnatal erythropoiesis. |
| doi_str_mv | 10.1542/peds.96.3.475 |
| format | Article |
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We measured ANRBC counts in the first 6 days of life in appropriate for gestational age newborns at 32 weeks' gestation or earlier with (n = 46) and without (n = 103) IVH, who were not at risk for altered erythropoiesis.
The ANRBC counts at birth were higher in infants who developed severe IVH than in control infants without IVH (P < .03). The ANRBC counts peaked on day 2 or 3 in newborns with IVH, but declined continuously from a peak on day 1 in the control group. Stepwise regression analysis of multiple variables revealed that the grade of IVH had the greatest impact on ANRBC counts. An ANRBC count of at least 2.0 x 10(9)/L on day 1 of life had a sensitivity of 63% and a specificity of 79% in predicting grade III or IV IVH:
An elevated or increasing ANRBC count in a preterm newborn is a potential marker for an impending or present severe IVH, respectively, and may reflect a state of altered prenatal or postnatal erythropoiesis.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.96.3.475</identifier><identifier>PMID: 7651781</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - analysis ; Brain ; Brain hemorrhage ; Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - etiology ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Erythroblasts ; Erythrocyte Count ; Erythrocytes ; Erythropoiesis ; Fetal Diseases - blood ; Fetal Diseases - diagnosis ; Health aspects ; Hemorrhage ; Humans ; Hypoxia - blood ; Hypoxia - complications ; Hypoxia - diagnosis ; Infant, Newborn ; Infant, Premature - blood ; Infant, Premature, Diseases - blood ; Infants (Premature) ; Intensive care medicine ; Measurement ; Medical sciences ; Pediatrics ; Premature infants ; Red blood cells ; Regression Analysis ; Sensitivity and Specificity</subject><ispartof>Pediatrics (Evanston), 1995-09, Vol.96 (3), p.475-478</ispartof><rights>1995 INIST-CNRS</rights><rights>COPYRIGHT 1995 American Academy of Pediatrics</rights><rights>COPYRIGHT 1995 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Sep 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-8e5d7ec93ad337ce13c48c94ecd00f487224801b32767c2715cc36d323b7083b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3657606$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7651781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GREEN, D. W</creatorcontrib><creatorcontrib>HENDON, B</creatorcontrib><creatorcontrib>MIMOUNI, F. B</creatorcontrib><title>Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Increased circulating nucleated erythrocytes (NRBCs) in the newborn period can be markers of chronic fetal hypoxia, which in turn may be a risk factor for intracranial hemorrhage (IVH). To evaluate the relation between chronic intrauterine hypoxia and IVH, we compared the courses of the absolute NRBC (ANRBC) count in preterm newborns with and without intracranial hemorrhage.
We measured ANRBC counts in the first 6 days of life in appropriate for gestational age newborns at 32 weeks' gestation or earlier with (n = 46) and without (n = 103) IVH, who were not at risk for altered erythropoiesis.
The ANRBC counts at birth were higher in infants who developed severe IVH than in control infants without IVH (P < .03). The ANRBC counts peaked on day 2 or 3 in newborns with IVH, but declined continuously from a peak on day 1 in the control group. Stepwise regression analysis of multiple variables revealed that the grade of IVH had the greatest impact on ANRBC counts. An ANRBC count of at least 2.0 x 10(9)/L on day 1 of life had a sensitivity of 63% and a specificity of 79% in predicting grade III or IV IVH:
An elevated or increasing ANRBC count in a preterm newborn is a potential marker for an impending or present severe IVH, respectively, and may reflect a state of altered prenatal or postnatal erythropoiesis.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Brain</subject><subject>Brain hemorrhage</subject><subject>Cerebral Hemorrhage - blood</subject><subject>Cerebral Hemorrhage - etiology</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Erythroblasts</subject><subject>Erythrocyte Count</subject><subject>Erythrocytes</subject><subject>Erythropoiesis</subject><subject>Fetal Diseases - blood</subject><subject>Fetal Diseases - diagnosis</subject><subject>Health aspects</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Hypoxia - blood</subject><subject>Hypoxia - complications</subject><subject>Hypoxia - diagnosis</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infants (Premature)</subject><subject>Intensive care medicine</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Pediatrics</subject><subject>Premature infants</subject><subject>Red blood cells</subject><subject>Regression Analysis</subject><subject>Sensitivity and Specificity</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkt1r2zAUxcXY6LJuj3scmDHGHupMn772YwlbuxLal-1ZKNK14yLLmWSX5b-vQkOhIwgkuOfH4ehyCPnI6JIpyb_v0KVlUy3FUoJ6RRaMNnUpOajXZEGpYKWkVL0l71K6p5RKBfyMnEGlGNRsQW5uZ-vRTOgKjPtpG0e7nzAVJriiD1M0D5jv3s7exGKLwxjj1nSYtWIXccI4FAHHkA3Se_KmNT7hh-N7Tv78_PF7dV2u765-rS7XpZV1M5U1KgdoG2GcEGCRiTy3jUTrKG1lDZzLmrKN4FCB5cCUtaJygosN0FpsxDn5-uS7i-PfGdOkhz5Z9N7kJHPSABIk500GP_8H3o9zDDmb5ryWVABAhi6eoM541H1ox_xp22HAaPwYsO3z-JKBbCqgB8_yBJ6Pw6G3p_hvL_iMTPhv6syckq6v1i_Qi1OoHb3HDnXe4eruVBIbx5QitnoX-8HEvWZUH5qhD83QTaWFzs3I_KfjNubNgO6ZPlYh61-OuknW-DaaYPv0jIlKQUUr8Qjha77B</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>GREEN, D. W</creator><creator>HENDON, B</creator><creator>MIMOUNI, F. B</creator><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates</title><author>GREEN, D. W ; HENDON, B ; MIMOUNI, F. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-8e5d7ec93ad337ce13c48c94ecd00f487224801b32767c2715cc36d323b7083b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Brain</topic><topic>Brain hemorrhage</topic><topic>Cerebral Hemorrhage - blood</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Erythroblasts</topic><topic>Erythrocyte Count</topic><topic>Erythrocytes</topic><topic>Erythropoiesis</topic><topic>Fetal Diseases - blood</topic><topic>Fetal Diseases - diagnosis</topic><topic>Health aspects</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Hypoxia - blood</topic><topic>Hypoxia - complications</topic><topic>Hypoxia - diagnosis</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infants (Premature)</topic><topic>Intensive care medicine</topic><topic>Measurement</topic><topic>Medical sciences</topic><topic>Pediatrics</topic><topic>Premature infants</topic><topic>Red blood cells</topic><topic>Regression Analysis</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GREEN, D. W</creatorcontrib><creatorcontrib>HENDON, B</creatorcontrib><creatorcontrib>MIMOUNI, F. B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GREEN, D. W</au><au>HENDON, B</au><au>MIMOUNI, F. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>96</volume><issue>3</issue><spage>475</spage><epage>478</epage><pages>475-478</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Increased circulating nucleated erythrocytes (NRBCs) in the newborn period can be markers of chronic fetal hypoxia, which in turn may be a risk factor for intracranial hemorrhage (IVH). To evaluate the relation between chronic intrauterine hypoxia and IVH, we compared the courses of the absolute NRBC (ANRBC) count in preterm newborns with and without intracranial hemorrhage.
We measured ANRBC counts in the first 6 days of life in appropriate for gestational age newborns at 32 weeks' gestation or earlier with (n = 46) and without (n = 103) IVH, who were not at risk for altered erythropoiesis.
The ANRBC counts at birth were higher in infants who developed severe IVH than in control infants without IVH (P < .03). The ANRBC counts peaked on day 2 or 3 in newborns with IVH, but declined continuously from a peak on day 1 in the control group. Stepwise regression analysis of multiple variables revealed that the grade of IVH had the greatest impact on ANRBC counts. An ANRBC count of at least 2.0 x 10(9)/L on day 1 of life had a sensitivity of 63% and a specificity of 79% in predicting grade III or IV IVH:
An elevated or increasing ANRBC count in a preterm newborn is a potential marker for an impending or present severe IVH, respectively, and may reflect a state of altered prenatal or postnatal erythropoiesis.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>7651781</pmid><doi>10.1542/peds.96.3.475</doi><tpages>4</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - analysis Brain Brain hemorrhage Cerebral Hemorrhage - blood Cerebral Hemorrhage - etiology Emergency and intensive care: neonates and children. Prematurity. Sudden death Erythroblasts Erythrocyte Count Erythrocytes Erythropoiesis Fetal Diseases - blood Fetal Diseases - diagnosis Health aspects Hemorrhage Humans Hypoxia - blood Hypoxia - complications Hypoxia - diagnosis Infant, Newborn Infant, Premature - blood Infant, Premature, Diseases - blood Infants (Premature) Intensive care medicine Measurement Medical sciences Pediatrics Premature infants Red blood cells Regression Analysis Sensitivity and Specificity |
| title | Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates |
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