Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover nonpeptidic HIV protease inhibitors had previously identified compound II (phenprocoumon, K(i) = 1 m...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-09, Vol.38 (18), p.3624-3637
Hauptverfasser:	Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxycoumarins - chemistry 4-Hydroxycoumarins - pharmacology AIDS/HIV Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Binding Sites Biological and medical sciences Cell Line Computer Graphics Crystallography, X-Ray HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology HIV-1 - enzymology HIV-2 - enzymology Humans Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Pyrones - chemistry Pyrones - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
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