Excitability of ‘silent’ respiratory neurons during sleep-waking states: an iontophoretic study in undrugged chronic cats
An iontophoretic study of respiratory-related neurons (RN) was conducted in the medullary ventral respiratory area of chronically implanted, undrugged cats during states of sleep and wakefulness. Most RN recorded were unaffected by sleep-wake states but a few RN decreased their firing rate during sl...
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| Veröffentlicht in: | Brain research 1987-02, Vol.404 (1), p.10-20 |
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| creator | Foutz, A.S. Boudinot, E. Morin-Surun, M.-P. Champagnat, J. Gonsalves, S.F. Denavit-Saubié, M. |
| description | An iontophoretic study of respiratory-related neurons (RN) was conducted in the medullary ventral respiratory area of chronically implanted, undrugged cats during states of sleep and wakefulness. Most RN recorded were unaffected by sleep-wake states but a few RN decreased their firing rate during sleep (sleep sensitive cells). The excitability of RN was assessed in the different states by local application of
l-glutamate. Glutamate iontophoresis revealed the presence of 5 cells which were silent during sleep and completely or mostly silent during undisturbed wakefulness but always discharged with a respiratory-modulated pattern of the expiratory type in response to glutamate application. Arousing stimuli induced spontaneous firing of these cells and REM sleep reduced glutamate effectiveness. It was concluded that silent RN and RN which become inactive during sleep permanently receive subthreshold respiratory-modulated inputs which are amplified or depressed by state-dependent tonic inputs. |
| doi_str_mv | 10.1016/0006-8993(87)91350-3 |
| format | Article |
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l-glutamate. Glutamate iontophoresis revealed the presence of 5 cells which were silent during sleep and completely or mostly silent during undisturbed wakefulness but always discharged with a respiratory-modulated pattern of the expiratory type in response to glutamate application. Arousing stimuli induced spontaneous firing of these cells and REM sleep reduced glutamate effectiveness. It was concluded that silent RN and RN which become inactive during sleep permanently receive subthreshold respiratory-modulated inputs which are amplified or depressed by state-dependent tonic inputs.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(87)91350-3</identifier><identifier>PMID: 2882809</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cats ; Chronic cat ; Electrodes, Implanted ; Fundamental and applied biological sciences. Psychology ; Glutamate ; Glutamates - pharmacology ; Glutamic Acid ; Iontophoresis ; Medulla Oblongata - cytology ; Medulla Oblongata - physiology ; Neurons - physiology ; Respiration ; Respiratory System - innervation ; Sleep - physiology ; Sleep waking ; Sleep. Vigilance ; Vertebrates: nervous system and sense organs ; Wakefulness - physiology</subject><ispartof>Brain research, 1987-02, Vol.404 (1), p.10-20</ispartof><rights>1987 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-96f231966ccff4bda88c3f5d5f77a8c60d30fd4214a8bd7e989e9e847ff0d7ed3</citedby><cites>FETCH-LOGICAL-c417t-96f231966ccff4bda88c3f5d5f77a8c60d30fd4214a8bd7e989e9e847ff0d7ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(87)91350-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8333973$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2882809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foutz, A.S.</creatorcontrib><creatorcontrib>Boudinot, E.</creatorcontrib><creatorcontrib>Morin-Surun, M.-P.</creatorcontrib><creatorcontrib>Champagnat, J.</creatorcontrib><creatorcontrib>Gonsalves, S.F.</creatorcontrib><creatorcontrib>Denavit-Saubié, M.</creatorcontrib><title>Excitability of ‘silent’ respiratory neurons during sleep-waking states: an iontophoretic study in undrugged chronic cats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>An iontophoretic study of respiratory-related neurons (RN) was conducted in the medullary ventral respiratory area of chronically implanted, undrugged cats during states of sleep and wakefulness. Most RN recorded were unaffected by sleep-wake states but a few RN decreased their firing rate during sleep (sleep sensitive cells). The excitability of RN was assessed in the different states by local application of
l-glutamate. Glutamate iontophoresis revealed the presence of 5 cells which were silent during sleep and completely or mostly silent during undisturbed wakefulness but always discharged with a respiratory-modulated pattern of the expiratory type in response to glutamate application. Arousing stimuli induced spontaneous firing of these cells and REM sleep reduced glutamate effectiveness. It was concluded that silent RN and RN which become inactive during sleep permanently receive subthreshold respiratory-modulated inputs which are amplified or depressed by state-dependent tonic inputs.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Chronic cat</subject><subject>Electrodes, Implanted</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamate</subject><subject>Glutamates - pharmacology</subject><subject>Glutamic Acid</subject><subject>Iontophoresis</subject><subject>Medulla Oblongata - cytology</subject><subject>Medulla Oblongata - physiology</subject><subject>Neurons - physiology</subject><subject>Respiration</subject><subject>Respiratory System - innervation</subject><subject>Sleep - physiology</subject><subject>Sleep waking</subject><subject>Sleep. Vigilance</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wakefulness - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFDEYxYModa2-gUIuROzF1GSSnSS9EKTUP1DwRq9DNvmyjc4mY5JR90LoY-jr9Uk60132sl6Fw_l9h3AOQs8pOaWEdm8IIV0jlWKvpThRlC1Jwx6gBZWibbqWk4docUAeoyelfJskY4ocoaNWylYStUB_Ln7bUM0q9KFucfL45vpvCT3EenP9D2coQ8imprzFEcacYsFuzCGucekBhuaX-X4nqqlQzrCJOKRY03CVMtRgJ2N0WxwiHqPL43oNDturKWayrKnlKXrkTV_g2f49Rl_fX3w5_9hcfv7w6fzdZWM5FbVRnW8ZVV1nrfd85YyUlvmlW3ohjLQdcYx4x1vKjVw5AUoqUCC58J5M0rFj9GqXO-T0Y4RS9SYUC31vIqSxaCG4oEqK_4KUd4JwNoN8B9qcSsng9ZDDxuStpkTP8-i5ez13r6XQd_NoNp292OePqw24w9F-j8l_ufdNsab32UQbygGTbNpPzDFvdxhMpf0MkHWxAaIFFzLYql0K9__jFpCgsOQ</recordid><startdate>19870224</startdate><enddate>19870224</enddate><creator>Foutz, A.S.</creator><creator>Boudinot, E.</creator><creator>Morin-Surun, M.-P.</creator><creator>Champagnat, J.</creator><creator>Gonsalves, S.F.</creator><creator>Denavit-Saubié, M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19870224</creationdate><title>Excitability of ‘silent’ respiratory neurons during sleep-waking states: an iontophoretic study in undrugged chronic cats</title><author>Foutz, A.S. ; Boudinot, E. ; Morin-Surun, M.-P. ; Champagnat, J. ; Gonsalves, S.F. ; Denavit-Saubié, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-96f231966ccff4bda88c3f5d5f77a8c60d30fd4214a8bd7e989e9e847ff0d7ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Chronic cat</topic><topic>Electrodes, Implanted</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamate</topic><topic>Glutamates - pharmacology</topic><topic>Glutamic Acid</topic><topic>Iontophoresis</topic><topic>Medulla Oblongata - cytology</topic><topic>Medulla Oblongata - physiology</topic><topic>Neurons - physiology</topic><topic>Respiration</topic><topic>Respiratory System - innervation</topic><topic>Sleep - physiology</topic><topic>Sleep waking</topic><topic>Sleep. Vigilance</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foutz, A.S.</creatorcontrib><creatorcontrib>Boudinot, E.</creatorcontrib><creatorcontrib>Morin-Surun, M.-P.</creatorcontrib><creatorcontrib>Champagnat, J.</creatorcontrib><creatorcontrib>Gonsalves, S.F.</creatorcontrib><creatorcontrib>Denavit-Saubié, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foutz, A.S.</au><au>Boudinot, E.</au><au>Morin-Surun, M.-P.</au><au>Champagnat, J.</au><au>Gonsalves, S.F.</au><au>Denavit-Saubié, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excitability of ‘silent’ respiratory neurons during sleep-waking states: an iontophoretic study in undrugged chronic cats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1987-02-24</date><risdate>1987</risdate><volume>404</volume><issue>1</issue><spage>10</spage><epage>20</epage><pages>10-20</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>An iontophoretic study of respiratory-related neurons (RN) was conducted in the medullary ventral respiratory area of chronically implanted, undrugged cats during states of sleep and wakefulness. Most RN recorded were unaffected by sleep-wake states but a few RN decreased their firing rate during sleep (sleep sensitive cells). The excitability of RN was assessed in the different states by local application of
l-glutamate. Glutamate iontophoresis revealed the presence of 5 cells which were silent during sleep and completely or mostly silent during undisturbed wakefulness but always discharged with a respiratory-modulated pattern of the expiratory type in response to glutamate application. Arousing stimuli induced spontaneous firing of these cells and REM sleep reduced glutamate effectiveness. It was concluded that silent RN and RN which become inactive during sleep permanently receive subthreshold respiratory-modulated inputs which are amplified or depressed by state-dependent tonic inputs.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2882809</pmid><doi>10.1016/0006-8993(87)91350-3</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Cats Chronic cat Electrodes, Implanted Fundamental and applied biological sciences. Psychology Glutamate Glutamates - pharmacology Glutamic Acid Iontophoresis Medulla Oblongata - cytology Medulla Oblongata - physiology Neurons - physiology Respiration Respiratory System - innervation Sleep - physiology Sleep waking Sleep. Vigilance Vertebrates: nervous system and sense organs Wakefulness - physiology |
| title | Excitability of ‘silent’ respiratory neurons during sleep-waking states: an iontophoretic study in undrugged chronic cats |
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