The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3
Growth hormone receptor (GHR) signaling involves activation of the Janus Kinases (Jak) and of Stat proteins (signal transducers and activators of transcription). Growth hormone (GH) induces transcriptional activation of c- fos gene and the c-sis inducible element (SIE) of its promoter was shown to b...
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| Veröffentlicht in: | FEBS letters 1995-08, Vol.369 (2), p.169-172 |
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| creator | Sotiropoulos, Athanassia Moutoussamy, Soraya Binart, Nadine Kelly, Paul A. Finidori, Joëlle |
| description | Growth hormone receptor (GHR) signaling involves activation of the Janus Kinases (Jak) and of Stat proteins (signal transducers and activators of transcription). Growth hormone (GH) induces transcriptional activation of c-
fos gene and the c-sis inducible element (SIE) of its promoter was shown to bind the Stat proteins. Using cells co-transfected with GHR and Stat 3 expression vectors, we directly demonstrate that GH induces tyrosine phosphorylation of Stat 3 and its binding to the SIE probe. We showed, using mutant forms of GHR, that only the cytoplasmic membrane proximal domain of the receptor, including a conserved proline rich region (box 1), is required for this effect. |
| doi_str_mv | 10.1016/0014-5793(95)00734-Q |
| format | Article |
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fos gene and the c-sis inducible element (SIE) of its promoter was shown to bind the Stat proteins. Using cells co-transfected with GHR and Stat 3 expression vectors, we directly demonstrate that GH induces tyrosine phosphorylation of Stat 3 and its binding to the SIE probe. We showed, using mutant forms of GHR, that only the cytoplasmic membrane proximal domain of the receptor, including a conserved proline rich region (box 1), is required for this effect.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(95)00734-Q</identifier><identifier>PMID: 7649252</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; c- fos ; c-sis-inducible element ; c-sis-inducible factor ; Cell Line ; Cell Membrane - metabolism ; CHO Cells ; Cricetinae ; Cytokine receptor ; Cytoplasm - metabolism ; DNA - metabolism ; DNA Probes ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; EGF ; epidermal growth factor ; GAS ; GHR ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; Growth hormone ; Growth Hormone - pharmacology ; growth hormone receptor ; hGH ; human growth hormone ; IFN ; IFNγ activation site ; interferon ; Jak ; Janus kinases ; Kinetics ; leukaemia inhibitory factor ; LIF ; Molecular Sequence Data ; p-Tyr ; PDGF ; Phosphorylation - drug effects ; phosphotyrosine ; platelet derived growth factor ; PRL ; prolactin ; Promoter Regions, Genetic - genetics ; Receptors, Somatotropin - genetics ; Receptors, Somatotropin - metabolism ; Sequence Deletion ; serum-inducible element ; SIE ; SIF ; signal transducer and activator of transcription ; Signal Transduction - physiology ; SRE ; Stat ; Stat 3 ; STAT3 Transcription Factor ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcriptional Activation - physiology ; Transfection</subject><ispartof>FEBS letters, 1995-08, Vol.369 (2), p.169-172</ispartof><rights>1995</rights><rights>FEBS Letters 369 (1995) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466Q-2a03b7c407f2fdd4593aa483ea77b7fa2f1f24e0d158fc4f2d86909994cd19ca3</citedby><cites>FETCH-LOGICAL-c466Q-2a03b7c407f2fdd4593aa483ea77b7fa2f1f24e0d158fc4f2d86909994cd19ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(95)00734-Q$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7649252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sotiropoulos, Athanassia</creatorcontrib><creatorcontrib>Moutoussamy, Soraya</creatorcontrib><creatorcontrib>Binart, Nadine</creatorcontrib><creatorcontrib>Kelly, Paul A.</creatorcontrib><creatorcontrib>Finidori, Joëlle</creatorcontrib><title>The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Growth hormone receptor (GHR) signaling involves activation of the Janus Kinases (Jak) and of Stat proteins (signal transducers and activators of transcription). Growth hormone (GH) induces transcriptional activation of c-
fos gene and the c-sis inducible element (SIE) of its promoter was shown to bind the Stat proteins. Using cells co-transfected with GHR and Stat 3 expression vectors, we directly demonstrate that GH induces tyrosine phosphorylation of Stat 3 and its binding to the SIE probe. We showed, using mutant forms of GHR, that only the cytoplasmic membrane proximal domain of the receptor, including a conserved proline rich region (box 1), is required for this effect.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>c- fos</subject><subject>c-sis-inducible element</subject><subject>c-sis-inducible factor</subject><subject>Cell Line</subject><subject>Cell Membrane - metabolism</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cytokine receptor</subject><subject>Cytoplasm - metabolism</subject><subject>DNA - metabolism</subject><subject>DNA Probes</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>EGF</subject><subject>epidermal growth factor</subject><subject>GAS</subject><subject>GHR</subject><subject>GM-CSF</subject><subject>granulocyte-macrophage colony-stimulating factor</subject><subject>Growth hormone</subject><subject>Growth Hormone - pharmacology</subject><subject>growth hormone receptor</subject><subject>hGH</subject><subject>human growth hormone</subject><subject>IFN</subject><subject>IFNγ activation site</subject><subject>interferon</subject><subject>Jak</subject><subject>Janus kinases</subject><subject>Kinetics</subject><subject>leukaemia inhibitory factor</subject><subject>LIF</subject><subject>Molecular Sequence Data</subject><subject>p-Tyr</subject><subject>PDGF</subject><subject>Phosphorylation - drug effects</subject><subject>phosphotyrosine</subject><subject>platelet derived growth factor</subject><subject>PRL</subject><subject>prolactin</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Receptors, Somatotropin - genetics</subject><subject>Receptors, Somatotropin - metabolism</subject><subject>Sequence Deletion</subject><subject>serum-inducible element</subject><subject>SIE</subject><subject>SIF</subject><subject>signal transducer and activator of transcription</subject><subject>Signal Transduction - physiology</subject><subject>SRE</subject><subject>Stat</subject><subject>Stat 3</subject><subject>STAT3 Transcription Factor</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Transcriptional Activation - physiology</subject><subject>Transfection</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFvGyEQhVHVKnXS_oNE4lQ1h21gYZflUqmN4qRSpMpKekYYhphq17iAnfqQ_x7WtnysegLmvXnDfAidU_KFEtpeEUJ51QjJPsvmkhDBeDV7gya0E6xivO3eosnR8h6dpvSblHdH5Qk6ES2XdVNP0MvjAvAAwzzqJeBVDH_9oHsc4cmHJQ4O56KbbQ6rXqfBG2zDoP1ReYrhOS_wIsQhlP4IBlY5ROwT9stN6Ddgy2Vn1Sb7jc6H2IesM2Yf0Dun-wQfD-cZ-jW9eby-q-5_3v64_nZfGd62s6rWhM2F4US42lnLG8m05h0DLcRcOF076moOxNKmc4a72natJFJKbiyVRrMz9GmfWxb8s4aU1eCTgb4vS4d1UkJwQbkUxcj3RhNDShGcWsUCJG4VJWqkrkakakSqZKN21NWstF0c8tfzAeyx6YC56NO9_ux72P5XpprefK9HYazLZlcdB33dB0GhtfEQVTIelgasL-yzssH_-6evckumug</recordid><startdate>19950807</startdate><enddate>19950807</enddate><creator>Sotiropoulos, Athanassia</creator><creator>Moutoussamy, Soraya</creator><creator>Binart, Nadine</creator><creator>Kelly, Paul A.</creator><creator>Finidori, Joëlle</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950807</creationdate><title>The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3</title><author>Sotiropoulos, Athanassia ; Moutoussamy, Soraya ; Binart, Nadine ; Kelly, Paul A. ; Finidori, Joëlle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466Q-2a03b7c407f2fdd4593aa483ea77b7fa2f1f24e0d158fc4f2d86909994cd19ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>c- fos</topic><topic>c-sis-inducible element</topic><topic>c-sis-inducible factor</topic><topic>Cell Line</topic><topic>Cell Membrane - metabolism</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Cytokine receptor</topic><topic>Cytoplasm - metabolism</topic><topic>DNA - metabolism</topic><topic>DNA Probes</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>EGF</topic><topic>epidermal growth factor</topic><topic>GAS</topic><topic>GHR</topic><topic>GM-CSF</topic><topic>granulocyte-macrophage colony-stimulating factor</topic><topic>Growth hormone</topic><topic>Growth Hormone - pharmacology</topic><topic>growth hormone receptor</topic><topic>hGH</topic><topic>human growth hormone</topic><topic>IFN</topic><topic>IFNγ activation site</topic><topic>interferon</topic><topic>Jak</topic><topic>Janus kinases</topic><topic>Kinetics</topic><topic>leukaemia inhibitory factor</topic><topic>LIF</topic><topic>Molecular Sequence Data</topic><topic>p-Tyr</topic><topic>PDGF</topic><topic>Phosphorylation - drug effects</topic><topic>phosphotyrosine</topic><topic>platelet derived growth factor</topic><topic>PRL</topic><topic>prolactin</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Receptors, Somatotropin - genetics</topic><topic>Receptors, Somatotropin - metabolism</topic><topic>Sequence Deletion</topic><topic>serum-inducible element</topic><topic>SIE</topic><topic>SIF</topic><topic>signal transducer and activator of transcription</topic><topic>Signal Transduction - physiology</topic><topic>SRE</topic><topic>Stat</topic><topic>Stat 3</topic><topic>STAT3 Transcription Factor</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><topic>Transcriptional Activation - physiology</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sotiropoulos, Athanassia</creatorcontrib><creatorcontrib>Moutoussamy, Soraya</creatorcontrib><creatorcontrib>Binart, Nadine</creatorcontrib><creatorcontrib>Kelly, Paul A.</creatorcontrib><creatorcontrib>Finidori, Joëlle</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sotiropoulos, Athanassia</au><au>Moutoussamy, Soraya</au><au>Binart, Nadine</au><au>Kelly, Paul A.</au><au>Finidori, Joëlle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1995-08-07</date><risdate>1995</risdate><volume>369</volume><issue>2</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Growth hormone receptor (GHR) signaling involves activation of the Janus Kinases (Jak) and of Stat proteins (signal transducers and activators of transcription). Growth hormone (GH) induces transcriptional activation of c-
fos gene and the c-sis inducible element (SIE) of its promoter was shown to bind the Stat proteins. Using cells co-transfected with GHR and Stat 3 expression vectors, we directly demonstrate that GH induces tyrosine phosphorylation of Stat 3 and its binding to the SIE probe. We showed, using mutant forms of GHR, that only the cytoplasmic membrane proximal domain of the receptor, including a conserved proline rich region (box 1), is required for this effect.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>7649252</pmid><doi>10.1016/0014-5793(95)00734-Q</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1995-08, Vol.369 (2), p.169-172 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Amino Acid Sequence Animals Base Sequence c- fos c-sis-inducible element c-sis-inducible factor Cell Line Cell Membrane - metabolism CHO Cells Cricetinae Cytokine receptor Cytoplasm - metabolism DNA - metabolism DNA Probes DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism EGF epidermal growth factor GAS GHR GM-CSF granulocyte-macrophage colony-stimulating factor Growth hormone Growth Hormone - pharmacology growth hormone receptor hGH human growth hormone IFN IFNγ activation site interferon Jak Janus kinases Kinetics leukaemia inhibitory factor LIF Molecular Sequence Data p-Tyr PDGF Phosphorylation - drug effects phosphotyrosine platelet derived growth factor PRL prolactin Promoter Regions, Genetic - genetics Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism Sequence Deletion serum-inducible element SIE SIF signal transducer and activator of transcription Signal Transduction - physiology SRE Stat Stat 3 STAT3 Transcription Factor Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation - physiology Transfection |
| title | The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3 |
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