Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases

The levels of the neuroprotective excitatory amino acid receptor antagonist kynurenic acid (KYNA) have been previously shown to be reduced in several regions of the brain of Huntington's disease (HD) patients. Thus, KYNA has been speculatively linked to the pathogenesis of HD. We have examined...

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Veröffentlicht in:	Journal of the neurological sciences 1995-05, Vol.130 (1), p.39-47
Hauptverfasser:	Jauch, Diana, Urbańska, Ewa M., Guidetti, Paolo, Bird, Edward D., Vonsattel, J.-P.G., Whetsell, William O., Schwarcz, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Brain - enzymology Brain - pathology Brain Chemistry - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Excitotoxins Female Humans Huntington Disease - enzymology Huntington Disease - metabolism Huntington Disease - pathology Kinetics Kynurenic Acid - metabolism Kynurenines Lyases Male Medical sciences Middle Aged Nerve Tissue Proteins - metabolism Neurodegenerative diseases Neurology Neuroprotection Transaminases - metabolism
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