Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease
Patterns of cerebral metabolic correlations were compared between 21 Alzheimer's disease patients and 21 healthy age-matched controls in the resting state. Cerebral metabolic rates for glucose were determined by positron emission tomography using [ 18F]2-fluoro-2-deoxy- d-glucose. Partial corre...
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| Veröffentlicht in: | Brain research 1987-03, Vol.407 (2), p.294-306 |
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| creator | Horwitz, B. Grady, C.L. Schlageter, N.L. Duara, R. Rapoport, S.I. |
| description | Patterns of cerebral metabolic correlations were compared between 21 Alzheimer's disease patients and 21 healthy age-matched controls in the resting state. Cerebral metabolic rates for glucose were determined by positron emission tomography using [
18F]2-fluoro-2-deoxy-
d-glucose. Partial correlation coefficients, controlling for whole brain glucose metabolism, were evaluated between pairs of regional glucose metabolic rates in 59 brain regions. Reliable correlation coefficients were obtained with the ‘jackknife’ and ‘bootstrap’ statistical procedures. Compared with healthy controls, the Alzheimer patients had significantly fewer reliable partial correlation coefficient between frontal and parietal lobe regions, and more reliable correlations between the cerebellum and temporal lobe. The number of reliable correlations between many bilaterally symmetric brain regions was reduced in the Alzheimer patients, as compared with controls. These results suggest that in the early stages of Alzheimer's disease there is a breakdown of the organized functional activity between the two cerebral hemispheres, and between parietal and frontal lobe structures. |
| doi_str_mv | 10.1016/0006-8993(87)91107-3 |
| format | Article |
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18F]2-fluoro-2-deoxy-
d-glucose. Partial correlation coefficients, controlling for whole brain glucose metabolism, were evaluated between pairs of regional glucose metabolic rates in 59 brain regions. Reliable correlation coefficients were obtained with the ‘jackknife’ and ‘bootstrap’ statistical procedures. Compared with healthy controls, the Alzheimer patients had significantly fewer reliable partial correlation coefficient between frontal and parietal lobe regions, and more reliable correlations between the cerebellum and temporal lobe. The number of reliable correlations between many bilaterally symmetric brain regions was reduced in the Alzheimer patients, as compared with controls. These results suggest that in the early stages of Alzheimer's disease there is a breakdown of the organized functional activity between the two cerebral hemispheres, and between parietal and frontal lobe structures.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(87)91107-3</identifier><identifier>PMID: 3494486</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Biological and medical sciences ; Brain - metabolism ; Correlation matrix ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Deoxyglucose ; Deoxyglucose - analogs & derivatives ; Deoxyglucose - metabolism ; Female ; Fluorodeoxyglucose F18 ; Frontal Lobe - metabolism ; Glucose - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parietal Lobe - metabolism ; Positron emission tomography ; Tomography, Emission-Computed</subject><ispartof>Brain research, 1987-03, Vol.407 (2), p.294-306</ispartof><rights>1987 Elsevier Publishers B.V. (Biomedical Division)</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-dd7d614a9a86912ffdf93c915064b6fc67f1ef2e037876b1d7f69109cd6eaca83</citedby><cites>FETCH-LOGICAL-c386t-dd7d614a9a86912ffdf93c915064b6fc67f1ef2e037876b1d7f69109cd6eaca83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(87)91107-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8258025$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3494486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horwitz, B.</creatorcontrib><creatorcontrib>Grady, C.L.</creatorcontrib><creatorcontrib>Schlageter, N.L.</creatorcontrib><creatorcontrib>Duara, R.</creatorcontrib><creatorcontrib>Rapoport, S.I.</creatorcontrib><title>Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Patterns of cerebral metabolic correlations were compared between 21 Alzheimer's disease patients and 21 healthy age-matched controls in the resting state. Cerebral metabolic rates for glucose were determined by positron emission tomography using [
18F]2-fluoro-2-deoxy-
d-glucose. Partial correlation coefficients, controlling for whole brain glucose metabolism, were evaluated between pairs of regional glucose metabolic rates in 59 brain regions. Reliable correlation coefficients were obtained with the ‘jackknife’ and ‘bootstrap’ statistical procedures. Compared with healthy controls, the Alzheimer patients had significantly fewer reliable partial correlation coefficient between frontal and parietal lobe regions, and more reliable correlations between the cerebellum and temporal lobe. The number of reliable correlations between many bilaterally symmetric brain regions was reduced in the Alzheimer patients, as compared with controls. These results suggest that in the early stages of Alzheimer's disease there is a breakdown of the organized functional activity between the two cerebral hemispheres, and between parietal and frontal lobe structures.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Correlation matrix</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Deoxyglucose</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Deoxyglucose - metabolism</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Frontal Lobe - metabolism</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parietal Lobe - metabolism</subject><subject>Positron emission tomography</subject><subject>Tomography, Emission-Computed</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVIcJ2Pf5DCHkrSHjaRVmt9XAImpG0g0EtyFlpp5KpoV65mXUh_fdax8TGnmeF9ZhgeQi4ZvWGUiVtKqaiV1vyrkt80Y1TW_IjMmZJNLZqWHpP5AflEThH_TCPnms7IjLe6bZWYk5fHYYTicimQ7BjzgFUOVYHV1NpUOSjQlalZpY3LCFUPo-1yiq4qdgSs4lAt0__fEHso11j5iGARzslJsAnhYl_PyMv3h-f7n_XTrx-P98un2nElxtp76QVrrbZKaNaE4IPmTrMFFW0nghMyMAgNUC6VFB3zMkwc1c4LsM4qfkaudnfXJf_dAI6mj-ggJTtA3qCRspWU6S3Y7kBXMmKBYNYl9ra8GkbN1qbZqjJbVUZJ827T8Gnt8_7-puvBH5b2-qb8yz636GwKxQ4u4gFTzULRZjFhdzsMJhf_IhSDLsLgwMcCbjQ-x4__eAPeh5GX</recordid><startdate>19870331</startdate><enddate>19870331</enddate><creator>Horwitz, B.</creator><creator>Grady, C.L.</creator><creator>Schlageter, N.L.</creator><creator>Duara, R.</creator><creator>Rapoport, S.I.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870331</creationdate><title>Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease</title><author>Horwitz, B. ; Grady, C.L. ; Schlageter, N.L. ; Duara, R. ; Rapoport, S.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-dd7d614a9a86912ffdf93c915064b6fc67f1ef2e037876b1d7f69109cd6eaca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Correlation matrix</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Deoxyglucose</topic><topic>Deoxyglucose - analogs & derivatives</topic><topic>Deoxyglucose - metabolism</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Frontal Lobe - metabolism</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parietal Lobe - metabolism</topic><topic>Positron emission tomography</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horwitz, B.</creatorcontrib><creatorcontrib>Grady, C.L.</creatorcontrib><creatorcontrib>Schlageter, N.L.</creatorcontrib><creatorcontrib>Duara, R.</creatorcontrib><creatorcontrib>Rapoport, S.I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horwitz, B.</au><au>Grady, C.L.</au><au>Schlageter, N.L.</au><au>Duara, R.</au><au>Rapoport, S.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1987-03-31</date><risdate>1987</risdate><volume>407</volume><issue>2</issue><spage>294</spage><epage>306</epage><pages>294-306</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Patterns of cerebral metabolic correlations were compared between 21 Alzheimer's disease patients and 21 healthy age-matched controls in the resting state. Cerebral metabolic rates for glucose were determined by positron emission tomography using [
18F]2-fluoro-2-deoxy-
d-glucose. Partial correlation coefficients, controlling for whole brain glucose metabolism, were evaluated between pairs of regional glucose metabolic rates in 59 brain regions. Reliable correlation coefficients were obtained with the ‘jackknife’ and ‘bootstrap’ statistical procedures. Compared with healthy controls, the Alzheimer patients had significantly fewer reliable partial correlation coefficient between frontal and parietal lobe regions, and more reliable correlations between the cerebellum and temporal lobe. The number of reliable correlations between many bilaterally symmetric brain regions was reduced in the Alzheimer patients, as compared with controls. These results suggest that in the early stages of Alzheimer's disease there is a breakdown of the organized functional activity between the two cerebral hemispheres, and between parietal and frontal lobe structures.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3494486</pmid><doi>10.1016/0006-8993(87)91107-3</doi><tpages>13</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer's disease Biological and medical sciences Brain - metabolism Correlation matrix Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Deoxyglucose Deoxyglucose - analogs & derivatives Deoxyglucose - metabolism Female Fluorodeoxyglucose F18 Frontal Lobe - metabolism Glucose - metabolism Humans Male Medical sciences Middle Aged Neurology Parietal Lobe - metabolism Positron emission tomography Tomography, Emission-Computed |
| title | Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease |
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