Carbachol-induced EEG ‘theta’ activity in hippocampal brain slices
Application of the cholinergic agonist carbachol (50 μM) produced θ-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus. Atropine sulfate (50 μM) antagonized the carbachol-induced θ-like activity, consistent with this action of atropine in vivo. These results provide t...
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| Veröffentlicht in: | Brain research 1987-03, Vol.405 (1), p.196-198 |
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| container_title | Brain research |
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| creator | Konopacki, Jan Bruce MacIver, M. Bland, Brian H. Roth, Sheldon H. |
| description | Application of the cholinergic agonist carbachol (50 μM) produced θ-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus. Atropine sulfate (50 μM) antagonized the carbachol-induced θ-like activity, consistent with this action of atropine in vivo. These results provide the first direct evidence that hippocampal neurons are capable of producing synchronized slow- wave activity when isolated from pulsed rhythmic inputs of the medial septum and other brain regions. |
| doi_str_mv | 10.1016/0006-8993(87)91009-2 |
| format | Article |
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Atropine sulfate (50 μM) antagonized the carbachol-induced θ-like activity, consistent with this action of atropine in vivo. These results provide the first direct evidence that hippocampal neurons are capable of producing synchronized slow- wave activity when isolated from pulsed rhythmic inputs of the medial septum and other brain regions.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(87)91009-2</identifier><identifier>PMID: 3567594</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Atropine - pharmacology ; Biological and medical sciences ; Biological Clocks ; Carbachol ; Carbachol - pharmacology ; Cholinergic Fibers - physiology ; Electro encephalogram (EEG) ; Electroencephalography ; Hippocampal brain slice ; Hippocampus - drug effects ; In Vitro Techniques ; Medical sciences ; Miscellaneous ; Muscarinic ; Neural Pathways - physiology ; Neuropharmacology ; Pharmacology. 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Atropine sulfate (50 μM) antagonized the carbachol-induced θ-like activity, consistent with this action of atropine in vivo. These results provide the first direct evidence that hippocampal neurons are capable of producing synchronized slow- wave activity when isolated from pulsed rhythmic inputs of the medial septum and other brain regions.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological Clocks</subject><subject>Carbachol</subject><subject>Carbachol - pharmacology</subject><subject>Cholinergic Fibers - physiology</subject><subject>Electro encephalogram (EEG)</subject><subject>Electroencephalography</subject><subject>Hippocampal brain slice</subject><subject>Hippocampus - drug effects</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Muscarinic</subject><subject>Neural Pathways - physiology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Septum Pellucidum - physiology</subject><subject>Theta Rhythm</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3DAQgEVpSTZJ36ABH0pID05kSdbPpVCWTVII5NKexVgasype25W8C7nlMZLXy5NE21322JyGmflmGL4h5EtFrypayWtKqSy1MfxSq2-motSU7AOZVVqxUjJBP5LZATkmJyn9ySnnhh6RI15LVRsxIzdziA245dCVofdrh75YLG6L16fnaYkTvD69FOCmsAnTYxH6YhnGcXCwGqErmgi5krrgMJ2RTy10CT_v4yn5fbP4Nb8r7x9uf85_3JdOaD6VWrSmRe0Etsp7BMS24Yi1ZB6MYqA8qxvPlNQtZ05UwBVy6gxAzbVEzk_JxW7vGIe_a0yTXYXksOugx2GdrFJCUVrLd8Eqc0YqnUGxA10cUorY2jGGFcRHW1G79Wy3Eu1WotXK_vNsWR473-9fNyv0h6G92Nz_uu9DctC1EXoX0gHLZ4qab7HvOwyztE3AaJML2Oc3hIhusn4I_7_jDX0Pmu0</recordid><startdate>19870303</startdate><enddate>19870303</enddate><creator>Konopacki, Jan</creator><creator>Bruce MacIver, M.</creator><creator>Bland, Brian H.</creator><creator>Roth, Sheldon H.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19870303</creationdate><title>Carbachol-induced EEG ‘theta’ activity in hippocampal brain slices</title><author>Konopacki, Jan ; Bruce MacIver, M. ; Bland, Brian H. ; Roth, Sheldon H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-84f9fe8c4ef7ddeaeefb3ee562da972a7d25bd2768f32c41a37e30c9aa5386e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biological Clocks</topic><topic>Carbachol</topic><topic>Carbachol - pharmacology</topic><topic>Cholinergic Fibers - physiology</topic><topic>Electro encephalogram (EEG)</topic><topic>Electroencephalography</topic><topic>Hippocampal brain slice</topic><topic>Hippocampus - drug effects</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Muscarinic</topic><topic>Neural Pathways - physiology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Septum Pellucidum - physiology</topic><topic>Theta Rhythm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Konopacki, Jan</creatorcontrib><creatorcontrib>Bruce MacIver, M.</creatorcontrib><creatorcontrib>Bland, Brian H.</creatorcontrib><creatorcontrib>Roth, Sheldon H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konopacki, Jan</au><au>Bruce MacIver, M.</au><au>Bland, Brian H.</au><au>Roth, Sheldon H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbachol-induced EEG ‘theta’ activity in hippocampal brain slices</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1987-03-03</date><risdate>1987</risdate><volume>405</volume><issue>1</issue><spage>196</spage><epage>198</epage><pages>196-198</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Application of the cholinergic agonist carbachol (50 μM) produced θ-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus. Atropine sulfate (50 μM) antagonized the carbachol-induced θ-like activity, consistent with this action of atropine in vivo. These results provide the first direct evidence that hippocampal neurons are capable of producing synchronized slow- wave activity when isolated from pulsed rhythmic inputs of the medial septum and other brain regions.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3567594</pmid><doi>10.1016/0006-8993(87)91009-2</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 1987-03, Vol.405 (1), p.196-198 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Atropine - pharmacology Biological and medical sciences Biological Clocks Carbachol Carbachol - pharmacology Cholinergic Fibers - physiology Electro encephalogram (EEG) Electroencephalography Hippocampal brain slice Hippocampus - drug effects In Vitro Techniques Medical sciences Miscellaneous Muscarinic Neural Pathways - physiology Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Septum Pellucidum - physiology Theta Rhythm |
| title | Carbachol-induced EEG ‘theta’ activity in hippocampal brain slices |
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