Vaccination of Cattle with the N-Terminus of L2 Is Necessary and Sufficient for Preventing Infection by Bovine Papillomavirus-4
We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was direct...
Gespeichert in:
| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1995-08, Vol.211 (1), p.204-208 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 208 |
|---|---|
| container_issue | 1 |
| container_start_page | 204 |
| container_title | Virology (New York, N.Y.) |
| container_volume | 211 |
| creator | Chandrachud, Lata M. Grindlay, G.Joan McGarvie, Gail M. O'Neil, Brian W. Wagner, Eric R. Jarrett, William F.H. Campo, M.Saveria |
| description | We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from vital challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals. |
| doi_str_mv | 10.1006/viro.1995.1392 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77463373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S004268228571392X</els_id><sourcerecordid>16846227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-3d1e56d4c8b7eb5519178e36d27c0ae76a867d6f6aa9898184f521b5ea8f79a03</originalsourceid><addsrcrecordid>eNqFkc1v1DAUxC0EKtvClQMSkk_cstiO448jrEpZaVUqteVqOc5za5TEi50s6ol_HYddcUOc_KyZN7bmh9AbStaUEPHhEFJcU62bNa01e4ZWlGhRkZrT52hFCGeVUIy9ROc5fyflLiU5Q2ey4ZzwZoV-fbPOhdFOIY44eryx09QD_hmmRzw9Ar6u7iANYZzzou4Y3mZ8DQ5ytukJ27HDt7P3wQUYJ-xjwjcJDmUO4wPejh7cn-D2CX-KhzACvrH70PdxsOXfc674K_TC2z7D69N5ge4_X95tvlS7r1fbzcdd5TjTU1V3FBrRcadaCW3TUE2lglp0TDpiQQqrhOyEF9ZqpRVV3DeMtg1Y5aW2pL5A74-5-xR_zJAnM4TsoO_tCHHORkou6lrW_zVSobhgTBbj-mh0KeacwJt9CkNpxVBiFjRmQWMWNGZBUxbenZLndoDur_3Eouhvj7q30diHFLK5v9VNoyWhRVRHEUpJhwDJ5KVzB11IpWTTxfCvd38DF1qmNg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16846227</pqid></control><display><type>article</type><title>Vaccination of Cattle with the N-Terminus of L2 Is Necessary and Sufficient for Preventing Infection by Bovine Papillomavirus-4</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Chandrachud, Lata M. ; Grindlay, G.Joan ; McGarvie, Gail M. ; O'Neil, Brian W. ; Wagner, Eric R. ; Jarrett, William F.H. ; Campo, M.Saveria</creator><creatorcontrib>Chandrachud, Lata M. ; Grindlay, G.Joan ; McGarvie, Gail M. ; O'Neil, Brian W. ; Wagner, Eric R. ; Jarrett, William F.H. ; Campo, M.Saveria</creatorcontrib><description>We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from vital challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1006/viro.1995.1392</identifier><identifier>PMID: 7544045</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Antibody Formation ; ANTIGENE ; ANTIGENOS ; B-Lymphocytes - immunology ; Bovine papillomavirus 1 - immunology ; Bovine papillomavirus 4 ; Capsid - chemistry ; Capsid - immunology ; Capsid Proteins ; Cattle ; Epitopes - immunology ; IMMUNITE HUMORALE ; INFECCION ; INFECTION ; INMUNIDAD HUMORAL ; LINFOCITOS ; LYMPHOCYTE ; Lymphocyte Activation ; Molecular Sequence Data ; Open Reading Frames ; Papilloma - immunology ; Papilloma - prevention & control ; PAPILLOMAVIRUS BOVIN ; Papillomavirus Infections - immunology ; Papillomavirus Infections - prevention & control ; Peptides - chemical synthesis ; Peptides - chemistry ; REPONSE IMMUNITAIRE ; RESPUESTA INMUNOLOGICA ; TERNERO ; Tumor Virus Infections - immunology ; Tumor Virus Infections - prevention & control ; VACCIN SYNTHETIQUE ; VACCINATION ; Vaccines, Synthetic - immunology ; VACUNA SINTETICA ; VACUNACION ; VEAU ; Viral Structural Proteins - chemistry ; Viral Structural Proteins - immunology ; Viral Vaccines ; VIRUS DEL PAPILOMA BOVINO</subject><ispartof>Virology (New York, N.Y.), 1995-08, Vol.211 (1), p.204-208</ispartof><rights>1995 Academic Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-3d1e56d4c8b7eb5519178e36d27c0ae76a867d6f6aa9898184f521b5ea8f79a03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/viro.1995.1392$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7544045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandrachud, Lata M.</creatorcontrib><creatorcontrib>Grindlay, G.Joan</creatorcontrib><creatorcontrib>McGarvie, Gail M.</creatorcontrib><creatorcontrib>O'Neil, Brian W.</creatorcontrib><creatorcontrib>Wagner, Eric R.</creatorcontrib><creatorcontrib>Jarrett, William F.H.</creatorcontrib><creatorcontrib>Campo, M.Saveria</creatorcontrib><title>Vaccination of Cattle with the N-Terminus of L2 Is Necessary and Sufficient for Preventing Infection by Bovine Papillomavirus-4</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from vital challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>ANTIGENE</subject><subject>ANTIGENOS</subject><subject>B-Lymphocytes - immunology</subject><subject>Bovine papillomavirus 1 - immunology</subject><subject>Bovine papillomavirus 4</subject><subject>Capsid - chemistry</subject><subject>Capsid - immunology</subject><subject>Capsid Proteins</subject><subject>Cattle</subject><subject>Epitopes - immunology</subject><subject>IMMUNITE HUMORALE</subject><subject>INFECCION</subject><subject>INFECTION</subject><subject>INMUNIDAD HUMORAL</subject><subject>LINFOCITOS</subject><subject>LYMPHOCYTE</subject><subject>Lymphocyte Activation</subject><subject>Molecular Sequence Data</subject><subject>Open Reading Frames</subject><subject>Papilloma - immunology</subject><subject>Papilloma - prevention & control</subject><subject>PAPILLOMAVIRUS BOVIN</subject><subject>Papillomavirus Infections - immunology</subject><subject>Papillomavirus Infections - prevention & control</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - chemistry</subject><subject>REPONSE IMMUNITAIRE</subject><subject>RESPUESTA INMUNOLOGICA</subject><subject>TERNERO</subject><subject>Tumor Virus Infections - immunology</subject><subject>Tumor Virus Infections - prevention & control</subject><subject>VACCIN SYNTHETIQUE</subject><subject>VACCINATION</subject><subject>Vaccines, Synthetic - immunology</subject><subject>VACUNA SINTETICA</subject><subject>VACUNACION</subject><subject>VEAU</subject><subject>Viral Structural Proteins - chemistry</subject><subject>Viral Structural Proteins - immunology</subject><subject>Viral Vaccines</subject><subject>VIRUS DEL PAPILOMA BOVINO</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAUxC0EKtvClQMSkk_cstiO448jrEpZaVUqteVqOc5za5TEi50s6ol_HYddcUOc_KyZN7bmh9AbStaUEPHhEFJcU62bNa01e4ZWlGhRkZrT52hFCGeVUIy9ROc5fyflLiU5Q2ey4ZzwZoV-fbPOhdFOIY44eryx09QD_hmmRzw9Ar6u7iANYZzzou4Y3mZ8DQ5ytukJ27HDt7P3wQUYJ-xjwjcJDmUO4wPejh7cn-D2CX-KhzACvrH70PdxsOXfc674K_TC2z7D69N5ge4_X95tvlS7r1fbzcdd5TjTU1V3FBrRcadaCW3TUE2lglp0TDpiQQqrhOyEF9ZqpRVV3DeMtg1Y5aW2pL5A74-5-xR_zJAnM4TsoO_tCHHORkou6lrW_zVSobhgTBbj-mh0KeacwJt9CkNpxVBiFjRmQWMWNGZBUxbenZLndoDur_3Eouhvj7q30diHFLK5v9VNoyWhRVRHEUpJhwDJ5KVzB11IpWTTxfCvd38DF1qmNg</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Chandrachud, Lata M.</creator><creator>Grindlay, G.Joan</creator><creator>McGarvie, Gail M.</creator><creator>O'Neil, Brian W.</creator><creator>Wagner, Eric R.</creator><creator>Jarrett, William F.H.</creator><creator>Campo, M.Saveria</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>Vaccination of Cattle with the N-Terminus of L2 Is Necessary and Sufficient for Preventing Infection by Bovine Papillomavirus-4</title><author>Chandrachud, Lata M. ; Grindlay, G.Joan ; McGarvie, Gail M. ; O'Neil, Brian W. ; Wagner, Eric R. ; Jarrett, William F.H. ; Campo, M.Saveria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-3d1e56d4c8b7eb5519178e36d27c0ae76a867d6f6aa9898184f521b5ea8f79a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>ANTIGENE</topic><topic>ANTIGENOS</topic><topic>B-Lymphocytes - immunology</topic><topic>Bovine papillomavirus 1 - immunology</topic><topic>Bovine papillomavirus 4</topic><topic>Capsid - chemistry</topic><topic>Capsid - immunology</topic><topic>Capsid Proteins</topic><topic>Cattle</topic><topic>Epitopes - immunology</topic><topic>IMMUNITE HUMORALE</topic><topic>INFECCION</topic><topic>INFECTION</topic><topic>INMUNIDAD HUMORAL</topic><topic>LINFOCITOS</topic><topic>LYMPHOCYTE</topic><topic>Lymphocyte Activation</topic><topic>Molecular Sequence Data</topic><topic>Open Reading Frames</topic><topic>Papilloma - immunology</topic><topic>Papilloma - prevention & control</topic><topic>PAPILLOMAVIRUS BOVIN</topic><topic>Papillomavirus Infections - immunology</topic><topic>Papillomavirus Infections - prevention & control</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - chemistry</topic><topic>REPONSE IMMUNITAIRE</topic><topic>RESPUESTA INMUNOLOGICA</topic><topic>TERNERO</topic><topic>Tumor Virus Infections - immunology</topic><topic>Tumor Virus Infections - prevention & control</topic><topic>VACCIN SYNTHETIQUE</topic><topic>VACCINATION</topic><topic>Vaccines, Synthetic - immunology</topic><topic>VACUNA SINTETICA</topic><topic>VACUNACION</topic><topic>VEAU</topic><topic>Viral Structural Proteins - chemistry</topic><topic>Viral Structural Proteins - immunology</topic><topic>Viral Vaccines</topic><topic>VIRUS DEL PAPILOMA BOVINO</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandrachud, Lata M.</creatorcontrib><creatorcontrib>Grindlay, G.Joan</creatorcontrib><creatorcontrib>McGarvie, Gail M.</creatorcontrib><creatorcontrib>O'Neil, Brian W.</creatorcontrib><creatorcontrib>Wagner, Eric R.</creatorcontrib><creatorcontrib>Jarrett, William F.H.</creatorcontrib><creatorcontrib>Campo, M.Saveria</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandrachud, Lata M.</au><au>Grindlay, G.Joan</au><au>McGarvie, Gail M.</au><au>O'Neil, Brian W.</au><au>Wagner, Eric R.</au><au>Jarrett, William F.H.</au><au>Campo, M.Saveria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination of Cattle with the N-Terminus of L2 Is Necessary and Sufficient for Preventing Infection by Bovine Papillomavirus-4</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>211</volume><issue>1</issue><spage>204</spage><epage>208</epage><pages>204-208</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from vital challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7544045</pmid><doi>10.1006/viro.1995.1392</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0042-6822 |
| ispartof | Virology (New York, N.Y.), 1995-08, Vol.211 (1), p.204-208 |
| issn | 0042-6822 1096-0341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77463373 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Amino Acid Sequence Animals Antibody Formation ANTIGENE ANTIGENOS B-Lymphocytes - immunology Bovine papillomavirus 1 - immunology Bovine papillomavirus 4 Capsid - chemistry Capsid - immunology Capsid Proteins Cattle Epitopes - immunology IMMUNITE HUMORALE INFECCION INFECTION INMUNIDAD HUMORAL LINFOCITOS LYMPHOCYTE Lymphocyte Activation Molecular Sequence Data Open Reading Frames Papilloma - immunology Papilloma - prevention & control PAPILLOMAVIRUS BOVIN Papillomavirus Infections - immunology Papillomavirus Infections - prevention & control Peptides - chemical synthesis Peptides - chemistry REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA TERNERO Tumor Virus Infections - immunology Tumor Virus Infections - prevention & control VACCIN SYNTHETIQUE VACCINATION Vaccines, Synthetic - immunology VACUNA SINTETICA VACUNACION VEAU Viral Structural Proteins - chemistry Viral Structural Proteins - immunology Viral Vaccines VIRUS DEL PAPILOMA BOVINO |
| title | Vaccination of Cattle with the N-Terminus of L2 Is Necessary and Sufficient for Preventing Infection by Bovine Papillomavirus-4 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T01%3A11%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vaccination%20of%20Cattle%20with%20the%20N-Terminus%20of%20L2%20Is%20Necessary%20and%20Sufficient%20for%20Preventing%20Infection%20by%20Bovine%20Papillomavirus-4&rft.jtitle=Virology%20(New%20York,%20N.Y.)&rft.au=Chandrachud,%20Lata%20M.&rft.date=1995-08-01&rft.volume=211&rft.issue=1&rft.spage=204&rft.epage=208&rft.pages=204-208&rft.issn=0042-6822&rft.eissn=1096-0341&rft_id=info:doi/10.1006/viro.1995.1392&rft_dat=%3Cproquest_cross%3E16846227%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16846227&rft_id=info:pmid/7544045&rft_els_id=S004268228571392X&rfr_iscdi=true |