Nucleosides and Nucleotides. 141. Chemical Stability of a New Antitumor Nucleoside, 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabino-pentofuranosylcytosine (CNDAC) in Alkaline Medium: Formation of 2'-C-Cyano-2'-deoxy-1-.beta.-D-ribo-pentofuranosylcytosine (CNDC) and Its Antitumor Activity

We have designed 2'-C-cyano-2'-deoxy-1-beta-D-arabino- pentofuranosylcytosine (CNDAC) as a potential mechanism-based DNA-strand-breaking nucleoside, which showed potent tumor cell growth inhibitory activity against various human tumor cell lines in vitro and in vivo. When measuring the pKa...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-08, Vol.38 (17), p.3391-3397
Hauptverfasser:	Azuma, Atsushi, Hanaoka, Kenji, Kurihara, Atsushi, Kobayashi, Tomowo, Miyauchi, Seiji, Kamo, Naoki, Tanaka, Motohiro, Sasaki, Takuma, Matsuda, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Cell Division - drug effects Colonic Neoplasms - pathology Cytarabine - analogs & derivatives Cytarabine - chemical synthesis Cytarabine - chemistry Cytarabine - pharmacology Drug Stability Female Humans Hydrogen-Ion Concentration Leukemia P388 - pathology Mice Mice, Inbred DBA Ribonucleosides - chemical synthesis Ribonucleosides - chemistry Ribonucleosides - pharmacology Spectrum Analysis Tumor Cells, Cultured
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