Bronchoalveolar mast cells in summer-type hypersensitivity pneumonitis : increase in numbers and ultrastructural evidence of degranulation
To investigate the role of mast cells in the development of summer-type hypersensitivity pneumonitis (SHP), which is the most common type of hypersensitivity pneumonitis in Japan, bronchoalveolar lavage fluid (BALF) cells from 13 patients with this disease was studied by light and electron microscop...
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| Veröffentlicht in: | Internal medicine (Tokyo, 1992) 1992), 1995, Vol.34 (5), p.357-363 |
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| container_issue | 5 |
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| container_title | Internal medicine (Tokyo, 1992) |
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| creator | ISHIDA, T MATSUI, Y MATSUMURA, Y FUJIMORI, N FURUTANI, M |
| description | To investigate the role of mast cells in the development of summer-type hypersensitivity pneumonitis (SHP), which is the most common type of hypersensitivity pneumonitis in Japan, bronchoalveolar lavage fluid (BALF) cells from 13 patients with this disease was studied by light and electron microscopy. The proportion and number of BALF mast cells recovered from SHP patients were significantly greater than those from patients with sarcoidosis and from control subjects. The BALF mast cells from the SHP patients showed various ultrastructural changes such as the transformation of granules, cytoplasmic vacuolation, and an increase of lipid droplets. These findings appeared to reflect activation and degranulation of bronchoalveolar mast cells, suggesting that mast cells play a role as inflammatory cells in the development of SHP. |
| doi_str_mv | 10.2169/internalmedicine.34.357 |
| format | Article |
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The proportion and number of BALF mast cells recovered from SHP patients were significantly greater than those from patients with sarcoidosis and from control subjects. The BALF mast cells from the SHP patients showed various ultrastructural changes such as the transformation of granules, cytoplasmic vacuolation, and an increase of lipid droplets. 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The proportion and number of BALF mast cells recovered from SHP patients were significantly greater than those from patients with sarcoidosis and from control subjects. The BALF mast cells from the SHP patients showed various ultrastructural changes such as the transformation of granules, cytoplasmic vacuolation, and an increase of lipid droplets. These findings appeared to reflect activation and degranulation of bronchoalveolar mast cells, suggesting that mast cells play a role as inflammatory cells in the development of SHP.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allergic diseases</subject><subject>Alveolitis, Extrinsic Allergic - etiology</subject><subject>Alveolitis, Extrinsic Allergic - pathology</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Cell Count</subject><subject>Cell Degranulation</subject><subject>Female</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Japan</subject><subject>Male</subject><subject>Mast Cells - ultrastructure</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Respiratory and ent allergic diseases</subject><subject>Retrospective Studies</subject><subject>Seasons</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcuKFDEUhoMoYzv6CGIW4q7apFK5uXMGbzDgRtdFKnXiRFJJm0tDv4JPbZppZuHmHA7_95-Q8yP0hpL9SIV-72OFHE3YYPXWR9izac-4fIJ2lE16kCPjT9GOaKqGsZfn6EUpvwlhSurxCl1JMcmJjDv09yanaO-TCUdIwWS8mVKxhRAK9hGXtm2Qh3o6AL7vJReIxVd_9PWEDxHalmIfC_7QaZvBFDjbYtuWzmITV9xCzX1nbra2bAKGo18hWsDJ4RV-ZRNbMNWn-BI9cyYUeHXp1-jn508_br8Od9-_fLv9eDdYTnQd9KKVGYFrSlY9LowoIhTnTDvnhOZ0Zc5oLp3Wi2GLXagEa8XCnCVEE0HZNXr3sPeQ058Gpc6bL-cfmwiplVnKSYxKiA7KB9DmVEoGNx-y30w-zZTM5xTm_1OY2TT3FLrz9eWJtnTt0Xc5e9ffXnRTrAmuH8H68ogxrphSnP0DrauaUA</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>ISHIDA, T</creator><creator>MATSUI, Y</creator><creator>MATSUMURA, Y</creator><creator>FUJIMORI, N</creator><creator>FURUTANI, M</creator><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Bronchoalveolar mast cells in summer-type hypersensitivity pneumonitis : increase in numbers and ultrastructural evidence of degranulation</title><author>ISHIDA, T ; MATSUI, Y ; MATSUMURA, Y ; FUJIMORI, N ; FURUTANI, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-9b98a2e5910d92b3080685539fff6951d3fa957f99ba3bcb17ecc6b3fc0090613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allergic diseases</topic><topic>Alveolitis, Extrinsic Allergic - etiology</topic><topic>Alveolitis, Extrinsic Allergic - pathology</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Cell Count</topic><topic>Cell Degranulation</topic><topic>Female</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Japan</topic><topic>Male</topic><topic>Mast Cells - ultrastructure</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Respiratory and ent allergic diseases</topic><topic>Retrospective Studies</topic><topic>Seasons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISHIDA, T</creatorcontrib><creatorcontrib>MATSUI, Y</creatorcontrib><creatorcontrib>MATSUMURA, Y</creatorcontrib><creatorcontrib>FUJIMORI, N</creatorcontrib><creatorcontrib>FURUTANI, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal medicine (Tokyo, 1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHIDA, T</au><au>MATSUI, Y</au><au>MATSUMURA, Y</au><au>FUJIMORI, N</au><au>FURUTANI, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchoalveolar mast cells in summer-type hypersensitivity pneumonitis : increase in numbers and ultrastructural evidence of degranulation</atitle><jtitle>Internal medicine (Tokyo, 1992)</jtitle><addtitle>Intern Med</addtitle><date>1995</date><risdate>1995</risdate><volume>34</volume><issue>5</issue><spage>357</spage><epage>363</epage><pages>357-363</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>To investigate the role of mast cells in the development of summer-type hypersensitivity pneumonitis (SHP), which is the most common type of hypersensitivity pneumonitis in Japan, bronchoalveolar lavage fluid (BALF) cells from 13 patients with this disease was studied by light and electron microscopy. The proportion and number of BALF mast cells recovered from SHP patients were significantly greater than those from patients with sarcoidosis and from control subjects. The BALF mast cells from the SHP patients showed various ultrastructural changes such as the transformation of granules, cytoplasmic vacuolation, and an increase of lipid droplets. These findings appeared to reflect activation and degranulation of bronchoalveolar mast cells, suggesting that mast cells play a role as inflammatory cells in the development of SHP.</abstract><cop>Tokyo</cop><pub>Japanese Society of Internal Medicine</pub><pmid>7647402</pmid><doi>10.2169/internalmedicine.34.357</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal medicine (Tokyo, 1992), 1995, Vol.34 (5), p.357-363 |
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| language | eng |
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| subjects | Adult Aged Aged, 80 and over Allergic diseases Alveolitis, Extrinsic Allergic - etiology Alveolitis, Extrinsic Allergic - pathology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Cell Count Cell Degranulation Female Humans Immunopathology Japan Male Mast Cells - ultrastructure Medical sciences Microscopy, Electron Middle Aged Respiratory and ent allergic diseases Retrospective Studies Seasons |
| title | Bronchoalveolar mast cells in summer-type hypersensitivity pneumonitis : increase in numbers and ultrastructural evidence of degranulation |
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