Secretion and processing mechanisms of procathepsin L in bone resorption

Secretion of procathepsin L into the culture medium from a bone cell mixture was markedly enhanced by addition parathyroid hormone (PTH), 1α,25-(OH) 2D 3 or tumor necrosis factor α (TNF α). These stimulators of secretion of procathepsin L enhanced bone pit formation, which was inhibited by E-64, but...

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Veröffentlicht in:	FEBS letters 1995-08, Vol.370 (1), p.78-82
Hauptverfasser:	Kakegawa, Hisao, Tagami, Kahori, Ohba, Yasuo, Sumitani, Koji, Kawata, Terushige, Katunumaa, Nobuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	1α25-(OH) 2D 3 1α25-(OH)2D3 Animals benzyloxycarbonyl Blotting, Western Bone and Bones - drug effects Bone and Bones - enzymology Bone Resorption CA-074 Calcitriol - pharmacology Calcium - deficiency Cathepsin L Cathepsins - biosynthesis Cathepsins - isolation & purification Cathepsins - metabolism Cells, Cultured Cysteine Endopeptidases Cysteine proteinase Cysteine Proteinase Inhibitors - pharmacology Dipeptides - pharmacology E-64-a EC 3.4.22.15 Electrophoresis, Polyacrylamide Gel Endopeptidases Enzyme Enzyme Precursors - isolation & purification Enzyme Precursors - metabolism Humans Leucine - analogs & derivatives Leucine - pharmacology Male MCA methylcoumaryl-amide Parathyroid Hormone - pharmacology Peptide Fragments - pharmacology Procathepsin L Protein Processing, Post-Translational PTH Rats Rats, Sprague-Dawley Teriparatide TNFα Tumor Necrosis Factor-alpha - pharmacology
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