Pharmacokinetics of isoprene in mice and rats

Pharmacokinetic analysis of isoprene inhaled by male Wistar rats and male B6C3F1 mice showed saturation kinetics in both species. Below atmospheric concentrations of 300 ppm in rats and in mice the rate of metabolism is directly proportional to the concentration. The low accumulation of isoprene in...

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Veröffentlicht in:	Toxicology letters 1987-03, Vol.36 (1), p.9-14
Hauptverfasser:	Peter, H., Wiegand, H.J., Bolt, H.M., Greim, H., Walter, G., Berg, M., Filser, J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Atmosphere Exposure Chambers Biological and medical sciences Butadienes - administration & dosage Butadienes - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Hemiterpenes inhalation Isoprene Kinetics Male Medical sciences Mice Pentanes pharmacokinetics Rats Rats, Inbred Strains Space life sciences Thermodynamics Toxicology Various organic compounds
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