Pharmacokinetics of isoprene in mice and rats
Pharmacokinetic analysis of isoprene inhaled by male Wistar rats and male B6C3F1 mice showed saturation kinetics in both species. Below atmospheric concentrations of 300 ppm in rats and in mice the rate of metabolism is directly proportional to the concentration. The low accumulation of isoprene in...
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| Veröffentlicht in: | Toxicology letters 1987-03, Vol.36 (1), p.9-14 |
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| creator | Peter, H. Wiegand, H.J. Bolt, H.M. Greim, H. Walter, G. Berg, M. Filser, J.G. |
| description | Pharmacokinetic analysis of isoprene inhaled by male Wistar rats and male B6C3F1 mice showed saturation kinetics in both species. Below atmospheric concentrations of 300 ppm in rats and in mice the rate of metabolism is directly proportional to the concentration. The low accumulation of isoprene in the body at low atmospheric concentrations suggests transport limitation of the metabolsm. Only small amounts of isoprene taken up are exhaled as unchanged substance (15% in rats and 25% in mice). Its half life in rats is 6.8 min and in mice 4.4 min. At concentrations above 300 ppm the rate of metabolism does not increase further in proportion to the atmospheric concentration. It finally approaches maximal values of 130 μmol/(h × kg) body weight at atmospheric concentrations above 1500 ppm in rats, and 400 μmol/(h × kg) body weight at concentrations above 2000 ppm in mice. This indicates limited production of the two possible mono-epoxides of isoprene at high concentrations.
Isoprene is endogenously produced and is systemically available. Its production rate is 1.9 μmol/(h × kg) in rats, and 0.4 μmol/(h × kg) in mice, respectively. Part of the endogenous isoprene is exhaled by the animals but it is metabolized to a greater extent: the rate of metabolism of endogenously produced and systemically available isoprene is 1.6 μmol/(h × kg) (rats) and 0.3 μmol/(h × kg) (mice). |
| doi_str_mv | 10.1016/0378-4274(87)90035-X |
| format | Article |
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Isoprene is endogenously produced and is systemically available. Its production rate is 1.9 μmol/(h × kg) in rats, and 0.4 μmol/(h × kg) in mice, respectively. Part of the endogenous isoprene is exhaled by the animals but it is metabolized to a greater extent: the rate of metabolism of endogenously produced and systemically available isoprene is 1.6 μmol/(h × kg) (rats) and 0.3 μmol/(h × kg) (mice).</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(87)90035-X</identifier><identifier>PMID: 3564074</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Inhalation ; Animals ; Atmosphere Exposure Chambers ; Biological and medical sciences ; Butadienes - administration & dosage ; Butadienes - metabolism ; Chemical and industrial products toxicology. Toxic occupational diseases ; Hemiterpenes ; inhalation ; Isoprene ; Kinetics ; Male ; Medical sciences ; Mice ; Pentanes ; pharmacokinetics ; Rats ; Rats, Inbred Strains ; Space life sciences ; Thermodynamics ; Toxicology ; Various organic compounds</subject><ispartof>Toxicology letters, 1987-03, Vol.36 (1), p.9-14</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-f0cf57d7ecc4f9a95e12423c0207328f86eeffed3804c331bcdc937fc3918e8c3</citedby><cites>FETCH-LOGICAL-c483t-f0cf57d7ecc4f9a95e12423c0207328f86eeffed3804c331bcdc937fc3918e8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(87)90035-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8268779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3564074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peter, H.</creatorcontrib><creatorcontrib>Wiegand, H.J.</creatorcontrib><creatorcontrib>Bolt, H.M.</creatorcontrib><creatorcontrib>Greim, H.</creatorcontrib><creatorcontrib>Walter, G.</creatorcontrib><creatorcontrib>Berg, M.</creatorcontrib><creatorcontrib>Filser, J.G.</creatorcontrib><title>Pharmacokinetics of isoprene in mice and rats</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Pharmacokinetic analysis of isoprene inhaled by male Wistar rats and male B6C3F1 mice showed saturation kinetics in both species. Below atmospheric concentrations of 300 ppm in rats and in mice the rate of metabolism is directly proportional to the concentration. The low accumulation of isoprene in the body at low atmospheric concentrations suggests transport limitation of the metabolsm. Only small amounts of isoprene taken up are exhaled as unchanged substance (15% in rats and 25% in mice). Its half life in rats is 6.8 min and in mice 4.4 min. At concentrations above 300 ppm the rate of metabolism does not increase further in proportion to the atmospheric concentration. It finally approaches maximal values of 130 μmol/(h × kg) body weight at atmospheric concentrations above 1500 ppm in rats, and 400 μmol/(h × kg) body weight at concentrations above 2000 ppm in mice. This indicates limited production of the two possible mono-epoxides of isoprene at high concentrations.
Isoprene is endogenously produced and is systemically available. Its production rate is 1.9 μmol/(h × kg) in rats, and 0.4 μmol/(h × kg) in mice, respectively. Part of the endogenous isoprene is exhaled by the animals but it is metabolized to a greater extent: the rate of metabolism of endogenously produced and systemically available isoprene is 1.6 μmol/(h × kg) (rats) and 0.3 μmol/(h × kg) (mice).</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Atmosphere Exposure Chambers</subject><subject>Biological and medical sciences</subject><subject>Butadienes - administration & dosage</subject><subject>Butadienes - metabolism</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Hemiterpenes</subject><subject>inhalation</subject><subject>Isoprene</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pentanes</subject><subject>pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Space life sciences</subject><subject>Thermodynamics</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotVb_gcIsRHQxmtdMko0gxRcUdKHQXUjv3GC0M1OTqeC_d2pLl7q6i_Odw-Uj5JjRS0ZZeUWF0rnkSp5rdWEoFUU-3SFDppXJBSvNLhlukX1ykNI7pbSUZTEgA1GUkio5JPnzm4u1g_YjNNgFSFnrs5DaRcQGs9BkdQDMXFNl0XXpkOx5N094tLkj8np3-zJ-yCdP94_jm0kOUosu9xR8oSqFANIbZwpkXHIBlFMluPa6RPQeK6GpBCHYDCowQnkQhmnUIEbkbL27iO3nElNn65AA53PXYLtMVilZMs7lvyCTmjNTrEC5BiG2KUX0dhFD7eK3ZdSudNqVK7tyZbWyvzrttK-dbPaXsxqrbWnjr89PN7lL4OY-ugZC2mKal1op02PXawx7aV8Bo00QsAGsQkTobNWGv__4AWoQj-o</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>Peter, H.</creator><creator>Wiegand, H.J.</creator><creator>Bolt, H.M.</creator><creator>Greim, H.</creator><creator>Walter, G.</creator><creator>Berg, M.</creator><creator>Filser, J.G.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19870301</creationdate><title>Pharmacokinetics of isoprene in mice and rats</title><author>Peter, H. ; Wiegand, H.J. ; Bolt, H.M. ; Greim, H. ; Walter, G. ; Berg, M. ; Filser, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-f0cf57d7ecc4f9a95e12423c0207328f86eeffed3804c331bcdc937fc3918e8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Atmosphere Exposure Chambers</topic><topic>Biological and medical sciences</topic><topic>Butadienes - administration & dosage</topic><topic>Butadienes - metabolism</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Hemiterpenes</topic><topic>inhalation</topic><topic>Isoprene</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pentanes</topic><topic>pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Space life sciences</topic><topic>Thermodynamics</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peter, H.</creatorcontrib><creatorcontrib>Wiegand, H.J.</creatorcontrib><creatorcontrib>Bolt, H.M.</creatorcontrib><creatorcontrib>Greim, H.</creatorcontrib><creatorcontrib>Walter, G.</creatorcontrib><creatorcontrib>Berg, M.</creatorcontrib><creatorcontrib>Filser, J.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peter, H.</au><au>Wiegand, H.J.</au><au>Bolt, H.M.</au><au>Greim, H.</au><au>Walter, G.</au><au>Berg, M.</au><au>Filser, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of isoprene in mice and rats</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>36</volume><issue>1</issue><spage>9</spage><epage>14</epage><pages>9-14</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Pharmacokinetic analysis of isoprene inhaled by male Wistar rats and male B6C3F1 mice showed saturation kinetics in both species. Below atmospheric concentrations of 300 ppm in rats and in mice the rate of metabolism is directly proportional to the concentration. The low accumulation of isoprene in the body at low atmospheric concentrations suggests transport limitation of the metabolsm. Only small amounts of isoprene taken up are exhaled as unchanged substance (15% in rats and 25% in mice). Its half life in rats is 6.8 min and in mice 4.4 min. At concentrations above 300 ppm the rate of metabolism does not increase further in proportion to the atmospheric concentration. It finally approaches maximal values of 130 μmol/(h × kg) body weight at atmospheric concentrations above 1500 ppm in rats, and 400 μmol/(h × kg) body weight at concentrations above 2000 ppm in mice. This indicates limited production of the two possible mono-epoxides of isoprene at high concentrations.
Isoprene is endogenously produced and is systemically available. Its production rate is 1.9 μmol/(h × kg) in rats, and 0.4 μmol/(h × kg) in mice, respectively. Part of the endogenous isoprene is exhaled by the animals but it is metabolized to a greater extent: the rate of metabolism of endogenously produced and systemically available isoprene is 1.6 μmol/(h × kg) (rats) and 0.3 μmol/(h × kg) (mice).</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>3564074</pmid><doi>10.1016/0378-4274(87)90035-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Inhalation Animals Atmosphere Exposure Chambers Biological and medical sciences Butadienes - administration & dosage Butadienes - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Hemiterpenes inhalation Isoprene Kinetics Male Medical sciences Mice Pentanes pharmacokinetics Rats Rats, Inbred Strains Space life sciences Thermodynamics Toxicology Various organic compounds |
| title | Pharmacokinetics of isoprene in mice and rats |
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