Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17β-hydroxysteroid dehydrogenase (17-β-HSD type 1)

The activity of 17β-HSD type 1, the enzyme that converts estrone into its more potent metabolite estradiol, has been demonstrated in all classical steroidogenic tissues and almost all peripheral tissues from both rat and human. Since 17β-HSD is one of the most important enzymes involved in active st...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1995-05, Vol.3 (5), p.505-523
Hauptverfasser:	Tremblay, Martin R., Auger, Serge, Poirier, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors Cytosol Estradiol - analogs & derivatives Estradiol - pharmacology Humans Placenta - enzymology Structure-Activity Relationship Substrate Specificity
Online-Zugang:	Volltext
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