Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein

The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA10...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1995-09, Vol.55 (17), p.3795-3802
Hauptverfasser:	Westerhof, G R, Rijnboutt, S, Schornagel, J H, Pinedo, H M, Peters, G J, Jansen, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopterin - analogs & derivatives Animals Carrier Proteins - physiology Cell Division - drug effects Female Folate Receptors, GPI-Anchored Folic Acid - analogs & derivatives Folic Acid - metabolism Folic Acid - pharmacology Folic Acid Antagonists - metabolism Folic Acid Antagonists - pharmacology Glutamates - biosynthesis Haplorhini Humans Kidney - metabolism Kidney - pathology Leucovorin - metabolism Methotrexate - metabolism Methotrexate - pharmacology Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Quinazolines - metabolism Quinazolines - pharmacology Receptors, Cell Surface Tetrahydrofolates - metabolism Tetrahydrofolates - pharmacology Thiophenes - metabolism Thiophenes - pharmacology Tumor Cells, Cultured
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