Induction of interleukin 1α in murine macrophages infected in vitro with different species and strains of Leishmania
It is now generally agreed that several cytokines released by immunocompetent cells such as macrophages play a crucial role in the outcome of infections caused by protozoa belonging to the genus Leishmania. In particular, tumor necrosis factor (TNF) induction during the course of cutaneous leishmani...
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| Veröffentlicht in: | Microbial pathogenesis 1995-02, Vol.18 (2), p.73-80 |
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| creator | Delfino, Demetrio Chiofalo, Maria Stefania Riggio, Giuseppe Angelici, Maria Cristina Gramiccia, Marina Gradoni, Luigi Iannello, Daniela |
| description | It is now generally agreed that several cytokines released by immunocompetent cells such as macrophages play a crucial role in the outcome of infections caused by protozoa belonging to the genus
Leishmania. In particular, tumor necrosis factor (TNF) induction during the course of cutaneous leishmaniasis has been related to resistance to
L. major infection in mice. However, the role played by interleukin 1 (IL-1) in the host response to leishmaniasis has yet to be completely elucidated. The aim of this work was to study whether different species and strains of
Leishmania could induce IL-1α in murine macrophages
in vitro. Resident peritoneal macrophages of BALB/c and C3H/HeN mice were infected with
L. donovani, L. major, or different strains of
L. infantum. It was found that
L. donovani did not induce IL-1α in macrophages from either mice strain. Infection with
L. major or with three out of six strains of
L. infantum induced consistent amounts of IL-1α, but only in macrophages from genetically resistant C3H/HeN mice. No relationship was found between the rate of infection of macrophages and the amount of IL-1α detected in the supernatants of infected macrophages. Data obtained confirm that the release of IL-1α by murine macrophages infected
in vitro with
Leishmania is influenced by the genetic background of the cells as well as by the parasite species. |
| doi_str_mv | 10.1016/S0882-4010(95)90077-2 |
| format | Article |
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Leishmania. In particular, tumor necrosis factor (TNF) induction during the course of cutaneous leishmaniasis has been related to resistance to
L. major infection in mice. However, the role played by interleukin 1 (IL-1) in the host response to leishmaniasis has yet to be completely elucidated. The aim of this work was to study whether different species and strains of
Leishmania could induce IL-1α in murine macrophages
in vitro. Resident peritoneal macrophages of BALB/c and C3H/HeN mice were infected with
L. donovani, L. major, or different strains of
L. infantum. It was found that
L. donovani did not induce IL-1α in macrophages from either mice strain. Infection with
L. major or with three out of six strains of
L. infantum induced consistent amounts of IL-1α, but only in macrophages from genetically resistant C3H/HeN mice. No relationship was found between the rate of infection of macrophages and the amount of IL-1α detected in the supernatants of infected macrophages. Data obtained confirm that the release of IL-1α by murine macrophages infected
in vitro with
Leishmania is influenced by the genetic background of the cells as well as by the parasite species.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/S0882-4010(95)90077-2</identifier><identifier>PMID: 7643744</identifier><identifier>CODEN: MIPAEV</identifier><language>eng</language><publisher>Oxford: Elsevier India Pvt Ltd</publisher><subject>Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; interleukin 1 ; Interleukin-1 - biosynthesis ; Leishmania ; Leishmania - genetics ; Leishmania - growth & development ; Leishmania - immunology ; Leishmania species ; Life cycle. Host-agent relationship. Pathogenesis ; macrophage ; Macrophage Activation ; Macrophages, Peritoneal - immunology ; Macrophages, Peritoneal - parasitology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Protozoa ; Species Specificity ; Time Factors</subject><ispartof>Microbial pathogenesis, 1995-02, Vol.18 (2), p.73-80</ispartof><rights>1995 Academic Press Limited</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-7e7f00fd319a3f456b45aa4330879d41e73e1aa0a49f6dcc2b81a5753a519d573</citedby><cites>FETCH-LOGICAL-c420t-7e7f00fd319a3f456b45aa4330879d41e73e1aa0a49f6dcc2b81a5753a519d573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0882-4010(95)90077-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3526012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7643744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delfino, Demetrio</creatorcontrib><creatorcontrib>Chiofalo, Maria Stefania</creatorcontrib><creatorcontrib>Riggio, Giuseppe</creatorcontrib><creatorcontrib>Angelici, Maria Cristina</creatorcontrib><creatorcontrib>Gramiccia, Marina</creatorcontrib><creatorcontrib>Gradoni, Luigi</creatorcontrib><creatorcontrib>Iannello, Daniela</creatorcontrib><title>Induction of interleukin 1α in murine macrophages infected in vitro with different species and strains of Leishmania</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>It is now generally agreed that several cytokines released by immunocompetent cells such as macrophages play a crucial role in the outcome of infections caused by protozoa belonging to the genus
Leishmania. In particular, tumor necrosis factor (TNF) induction during the course of cutaneous leishmaniasis has been related to resistance to
L. major infection in mice. However, the role played by interleukin 1 (IL-1) in the host response to leishmaniasis has yet to be completely elucidated. The aim of this work was to study whether different species and strains of
Leishmania could induce IL-1α in murine macrophages
in vitro. Resident peritoneal macrophages of BALB/c and C3H/HeN mice were infected with
L. donovani, L. major, or different strains of
L. infantum. It was found that
L. donovani did not induce IL-1α in macrophages from either mice strain. Infection with
L. major or with three out of six strains of
L. infantum induced consistent amounts of IL-1α, but only in macrophages from genetically resistant C3H/HeN mice. No relationship was found between the rate of infection of macrophages and the amount of IL-1α detected in the supernatants of infected macrophages. Data obtained confirm that the release of IL-1α by murine macrophages infected
in vitro with
Leishmania is influenced by the genetic background of the cells as well as by the parasite species.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>interleukin 1</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Leishmania</subject><subject>Leishmania - genetics</subject><subject>Leishmania - growth & development</subject><subject>Leishmania - immunology</subject><subject>Leishmania species</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>macrophage</subject><subject>Macrophage Activation</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Macrophages, Peritoneal - parasitology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Protozoa</subject><subject>Species Specificity</subject><subject>Time Factors</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnRjO3oI0xSC2N0UQoFFMXKmIk_k3TiQl2T23Cx0SqqBWqMj-WL-ExS053ezorA-e655BxCrhh9zSjr33yhw9C1gjL6UstXmlKl2u4B2TCq-5Z1dHhINmfkMXmS8w9KqRZcX5AL1QuuhNiQ5Sa6xZYwx2b2TYgF04jLzxAb9u9vvTfTkkLEZgKb5sMevmOurx5tQbfKt6Gkufkdyr5xwXtMGEuTD2hDBSG6JpcEIebVfYsh7yeIAZ6SRx7GjM9O5yX59uH91-tP7fbzx5vrd9vWio6WVqHylHrHmQbuhex3QgIIzumgtBMMFUcGQEFo3ztru93AQCrJQTLtpOKX5MXR95DmXwvmYqaQLY4jRJyXbFTNQLNhuBdk_cAY7_sKyiNY48g5oTeHFCZIfwyjZu3F3PVi1tCNluauF9PVuavTgmU3oTtPnYqo-vOTDtnC6BNEG_IZ47LrKVtt3h4xrKndBkwm16SjRRdS7cS4Odzzkf_Jf6tJ</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>Delfino, Demetrio</creator><creator>Chiofalo, Maria Stefania</creator><creator>Riggio, Giuseppe</creator><creator>Angelici, Maria Cristina</creator><creator>Gramiccia, Marina</creator><creator>Gradoni, Luigi</creator><creator>Iannello, Daniela</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>Induction of interleukin 1α in murine macrophages infected in vitro with different species and strains of Leishmania</title><author>Delfino, Demetrio ; Chiofalo, Maria Stefania ; Riggio, Giuseppe ; Angelici, Maria Cristina ; Gramiccia, Marina ; Gradoni, Luigi ; Iannello, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-7e7f00fd319a3f456b45aa4330879d41e73e1aa0a49f6dcc2b81a5753a519d573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>interleukin 1</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Leishmania</topic><topic>Leishmania - genetics</topic><topic>Leishmania - growth & development</topic><topic>Leishmania - immunology</topic><topic>Leishmania species</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>macrophage</topic><topic>Macrophage Activation</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Macrophages, Peritoneal - parasitology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Protozoa</topic><topic>Species Specificity</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delfino, Demetrio</creatorcontrib><creatorcontrib>Chiofalo, Maria Stefania</creatorcontrib><creatorcontrib>Riggio, Giuseppe</creatorcontrib><creatorcontrib>Angelici, Maria Cristina</creatorcontrib><creatorcontrib>Gramiccia, Marina</creatorcontrib><creatorcontrib>Gradoni, Luigi</creatorcontrib><creatorcontrib>Iannello, Daniela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delfino, Demetrio</au><au>Chiofalo, Maria Stefania</au><au>Riggio, Giuseppe</au><au>Angelici, Maria Cristina</au><au>Gramiccia, Marina</au><au>Gradoni, Luigi</au><au>Iannello, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of interleukin 1α in murine macrophages infected in vitro with different species and strains of Leishmania</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>18</volume><issue>2</issue><spage>73</spage><epage>80</epage><pages>73-80</pages><issn>0882-4010</issn><eissn>1096-1208</eissn><coden>MIPAEV</coden><abstract>It is now generally agreed that several cytokines released by immunocompetent cells such as macrophages play a crucial role in the outcome of infections caused by protozoa belonging to the genus
Leishmania. In particular, tumor necrosis factor (TNF) induction during the course of cutaneous leishmaniasis has been related to resistance to
L. major infection in mice. However, the role played by interleukin 1 (IL-1) in the host response to leishmaniasis has yet to be completely elucidated. The aim of this work was to study whether different species and strains of
Leishmania could induce IL-1α in murine macrophages
in vitro. Resident peritoneal macrophages of BALB/c and C3H/HeN mice were infected with
L. donovani, L. major, or different strains of
L. infantum. It was found that
L. donovani did not induce IL-1α in macrophages from either mice strain. Infection with
L. major or with three out of six strains of
L. infantum induced consistent amounts of IL-1α, but only in macrophages from genetically resistant C3H/HeN mice. No relationship was found between the rate of infection of macrophages and the amount of IL-1α detected in the supernatants of infected macrophages. Data obtained confirm that the release of IL-1α by murine macrophages infected
in vitro with
Leishmania is influenced by the genetic background of the cells as well as by the parasite species.</abstract><cop>Oxford</cop><pub>Elsevier India Pvt Ltd</pub><pmid>7643744</pmid><doi>10.1016/S0882-4010(95)90077-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0882-4010 |
| ispartof | Microbial pathogenesis, 1995-02, Vol.18 (2), p.73-80 |
| issn | 0882-4010 1096-1208 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77449188 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology In Vitro Techniques interleukin 1 Interleukin-1 - biosynthesis Leishmania Leishmania - genetics Leishmania - growth & development Leishmania - immunology Leishmania species Life cycle. Host-agent relationship. Pathogenesis macrophage Macrophage Activation Macrophages, Peritoneal - immunology Macrophages, Peritoneal - parasitology Mice Mice, Inbred BALB C Mice, Inbred C3H Protozoa Species Specificity Time Factors |
| title | Induction of interleukin 1α in murine macrophages infected in vitro with different species and strains of Leishmania |
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