Effects of lithium on rat parotid and submandibulary gland functions
1. 1. Pure submandibular and parotid saliva were collected intraorally by micro polyethylene canula from anesthetized lithium treated and control rats using pilocarpine as secretagogue. 2. 2. Acute intraperitoneal injection of a single dose of lithium chloride (10 mg/kg), caused a significant decrea...
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| Veröffentlicht in: | General pharmacology 1995-07, Vol.26 (4), p.851-854 |
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| container_title | General pharmacology |
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| creator | Dehpour, Ahmad-reza Abdollahi, Mohammad Alghasi, Hekmat |
| description | 1.
1. Pure submandibular and parotid saliva were collected intraorally by micro polyethylene canula from anesthetized lithium treated and control rats using pilocarpine as secretagogue.
2.
2. Acute intraperitoneal injection of a single dose of lithium chloride (10 mg/kg), caused a significant decrease in protein, calcium, potassium and sodium concentrations of parotid saliva and also a significant decrease in protein, potassium and calcium concentrations of submandibular saliva.
3.
3. Chronic treatment of rats for 10 days by LiCl solution (1200 mg/l) also caused some marked changes in saliva compositions similar to those observed in acute experiment.
4.
4. The results of this study suggest that lithium as a drug used in the treatment of affective disorders can influence the secretory mechanisms of both submandibular and parotid glands.
5.
5. These effects of lithium in composition of parotid and submandibular saliva are not related to duration of treatment. |
| doi_str_mv | 10.1016/0306-3623(94)00248-L |
| format | Article |
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1. Pure submandibular and parotid saliva were collected intraorally by micro polyethylene canula from anesthetized lithium treated and control rats using pilocarpine as secretagogue.
2.
2. Acute intraperitoneal injection of a single dose of lithium chloride (10 mg/kg), caused a significant decrease in protein, calcium, potassium and sodium concentrations of parotid saliva and also a significant decrease in protein, potassium and calcium concentrations of submandibular saliva.
3.
3. Chronic treatment of rats for 10 days by LiCl solution (1200 mg/l) also caused some marked changes in saliva compositions similar to those observed in acute experiment.
4.
4. The results of this study suggest that lithium as a drug used in the treatment of affective disorders can influence the secretory mechanisms of both submandibular and parotid glands.
5.
5. These effects of lithium in composition of parotid and submandibular saliva are not related to duration of treatment.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(94)00248-L</identifier><identifier>PMID: 7635260</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Calcium - metabolism ; Drug toxicity and drugs side effects treatment ; Lithium ; Lithium - pharmacokinetics ; Lithium - pharmacology ; Male ; Medical sciences ; Organ Size - drug effects ; parotid ; Parotid Gland - drug effects ; Parotid Gland - metabolism ; Pharmacology. Drug treatments ; Pilocarpine - pharmacology ; Potassium - metabolism ; Rats ; Rats, Sprague-Dawley ; saliva ; Salivary Proteins and Peptides - metabolism ; Salivation - drug effects ; Sodium - metabolism ; submandibular ; Submandibular Gland - drug effects ; Submandibular Gland - metabolism ; Toxicity: digestive system</subject><ispartof>General pharmacology, 1995-07, Vol.26 (4), p.851-854</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-a4b1efbe7e9f111c8e3aa41a5b2086087046a2f9514a665d09921c6ecf7b33c83</citedby><cites>FETCH-LOGICAL-c386t-a4b1efbe7e9f111c8e3aa41a5b2086087046a2f9514a665d09921c6ecf7b33c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3488950$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7635260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dehpour, Ahmad-reza</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><creatorcontrib>Alghasi, Hekmat</creatorcontrib><title>Effects of lithium on rat parotid and submandibulary gland functions</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. Pure submandibular and parotid saliva were collected intraorally by micro polyethylene canula from anesthetized lithium treated and control rats using pilocarpine as secretagogue.
2.
2. Acute intraperitoneal injection of a single dose of lithium chloride (10 mg/kg), caused a significant decrease in protein, calcium, potassium and sodium concentrations of parotid saliva and also a significant decrease in protein, potassium and calcium concentrations of submandibular saliva.
3.
3. Chronic treatment of rats for 10 days by LiCl solution (1200 mg/l) also caused some marked changes in saliva compositions similar to those observed in acute experiment.
4.
4. The results of this study suggest that lithium as a drug used in the treatment of affective disorders can influence the secretory mechanisms of both submandibular and parotid glands.
5.
5. These effects of lithium in composition of parotid and submandibular saliva are not related to duration of treatment.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Lithium</subject><subject>Lithium - pharmacokinetics</subject><subject>Lithium - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>parotid</subject><subject>Parotid Gland - drug effects</subject><subject>Parotid Gland - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilocarpine - pharmacology</subject><subject>Potassium - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>saliva</subject><subject>Salivary Proteins and Peptides - metabolism</subject><subject>Salivation - drug effects</subject><subject>Sodium - metabolism</subject><subject>submandibular</subject><subject>Submandibular Gland - drug effects</subject><subject>Submandibular Gland - metabolism</subject><subject>Toxicity: digestive system</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxRyENFDNV9Nk4sg6_oBBS96DmmaaKTbrkkr-O9N3bJHTwMzzwzvPACcYnSNEeY3iCKeUU7opWRXCBEmsnIPzLEoZIYQxvtgvkMOwVGMnyhROSEzMCs4zQlHc3C_cs6aPsLOwcb3H35Yw66FQfdwo0PX-xrqtoZxqNap-mpodPiB783YdENret-18RgcON1EezLVBXh7WL0un7Ly5fF5eVdmhgreZ5pV2LrKFlY6jLERlmrNsM4rggRHokCMa-JkjpnmPK-RlAQbbo0rKkqNoAtwsb27Cd3XYGOv1j4a26Q0thuiKgrGhJQ4gWwLmtDFGKxTm-DXKbnCSI3y1GhGjWaUZOpPnirT2tl0P71r693SZCvNz6e5jkY3LujW-LjDKBNC5iN2u8VscvHtbVDReNsaW_uQXKu68__n-AWEEopp</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Dehpour, Ahmad-reza</creator><creator>Abdollahi, Mohammad</creator><creator>Alghasi, Hekmat</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>Effects of lithium on rat parotid and submandibulary gland functions</title><author>Dehpour, Ahmad-reza ; Abdollahi, Mohammad ; Alghasi, Hekmat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a4b1efbe7e9f111c8e3aa41a5b2086087046a2f9514a665d09921c6ecf7b33c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Lithium</topic><topic>Lithium - pharmacokinetics</topic><topic>Lithium - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>parotid</topic><topic>Parotid Gland - drug effects</topic><topic>Parotid Gland - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilocarpine - pharmacology</topic><topic>Potassium - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>saliva</topic><topic>Salivary Proteins and Peptides - metabolism</topic><topic>Salivation - drug effects</topic><topic>Sodium - metabolism</topic><topic>submandibular</topic><topic>Submandibular Gland - drug effects</topic><topic>Submandibular Gland - metabolism</topic><topic>Toxicity: digestive system</topic><toplevel>online_resources</toplevel><creatorcontrib>Dehpour, Ahmad-reza</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><creatorcontrib>Alghasi, Hekmat</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dehpour, Ahmad-reza</au><au>Abdollahi, Mohammad</au><au>Alghasi, Hekmat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of lithium on rat parotid and submandibulary gland functions</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>26</volume><issue>4</issue><spage>851</spage><epage>854</epage><pages>851-854</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. Pure submandibular and parotid saliva were collected intraorally by micro polyethylene canula from anesthetized lithium treated and control rats using pilocarpine as secretagogue.
2.
2. Acute intraperitoneal injection of a single dose of lithium chloride (10 mg/kg), caused a significant decrease in protein, calcium, potassium and sodium concentrations of parotid saliva and also a significant decrease in protein, potassium and calcium concentrations of submandibular saliva.
3.
3. Chronic treatment of rats for 10 days by LiCl solution (1200 mg/l) also caused some marked changes in saliva compositions similar to those observed in acute experiment.
4.
4. The results of this study suggest that lithium as a drug used in the treatment of affective disorders can influence the secretory mechanisms of both submandibular and parotid glands.
5.
5. These effects of lithium in composition of parotid and submandibular saliva are not related to duration of treatment.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7635260</pmid><doi>10.1016/0306-3623(94)00248-L</doi><tpages>4</tpages></addata></record> |
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| ispartof | General pharmacology, 1995-07, Vol.26 (4), p.851-854 |
| issn | 0306-3623 1879-0011 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Calcium - metabolism Drug toxicity and drugs side effects treatment Lithium Lithium - pharmacokinetics Lithium - pharmacology Male Medical sciences Organ Size - drug effects parotid Parotid Gland - drug effects Parotid Gland - metabolism Pharmacology. Drug treatments Pilocarpine - pharmacology Potassium - metabolism Rats Rats, Sprague-Dawley saliva Salivary Proteins and Peptides - metabolism Salivation - drug effects Sodium - metabolism submandibular Submandibular Gland - drug effects Submandibular Gland - metabolism Toxicity: digestive system |
| title | Effects of lithium on rat parotid and submandibulary gland functions |
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