Henderson-hasselbalch equation is inadequate for the measurement of transmembrane diffusion of drugs and buccal drug absorption is a useful alternative

1. 1. The transmembrane diffusion of weakly acidic or basic drugs is being commonly assessed from their degree of ionization or ratio unionized/ionized forms (ratio U/I) as calculated from Henderson-Hasselbalch equation (HHEq). 2. 2. Buccal drug absorption (BA) at pH 5–9 has been proposed as an in v...

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Veröffentlicht in:	General pharmacology 1995-07, Vol.26 (4), p.875-879
Hauptverfasser:	Randhawa, M.A., Iqbal, A., Nasimullah, M., Akhtar, M., Yousaf, S.M., Turner, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acids - metabolism area under the curve buccal drug absorption Diffusion Henderson-Hasselbalch equation Hydrogen-Ion Concentration Membranes - metabolism Mouth Mucosa - metabolism Pharmacokinetics transmembrane diffusion
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